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BGC0000300NRPS

amychelin

Producing organism
Streptomyces sp. AA4
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
NRPS (Type I)
Total steps
10
DOI
MIBiG entry
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amychelin
C30H42N8O14738.28 Da

Gene Cluster Map16 genes · 35,238 bp

CyACACAECAECACAEA5 kb35.2 kb visible · 35,238 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
CcCOM C-term
EEpimerization (E)
CyHeterocyclization (Cy)

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1
Start
+Chorismate
Step 2
SSMG_02545
Step 3M1
SSMG_02542
Step 4M2
SSMG_02535
+Serine
Step 5M3
SSMG_02536
+Serine
Step 6M4
SSMG_02536
+Serine
Step 7M5
SSMG_02538
+Serine
Step 8M6
SSMG_02538
+N-Hydroxy-N-formy…
Step 9M7
SSMG_02537
+N-Hydroxy-ornithi…
Step 10TE
SSMG_02540
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1300-1Start
Chorismate
OC(C1=C[C@@H](CC(C(O)=O)=C)[C@H](O)C=C1)=O
2300-2SSMG_02545
300-1
from: 300-1
OC(C1=CC=CC=C1O)=O
3300-3SSMG_02542M1
300-2
from: 300-2
OC(C1=CC=CC=C1O)=O
4300-4SSMG_02535M2
Serine;300-3
from: 300-3
OC1=CC=CC=C1C2=N[C@@H](C(O)=O)CO2
5300-5SSMG_02536M3
Serine;300-4
from: 300-4
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(O)=O)=O)CO2
6300-6SSMG_02536M4
Serine;300-5
from: 300-5
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(O)=O)=O)=O)CO2
7300-7SSMG_02538M5
Serine;300-6
from: 300-6
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(N[C@@H](CC)C(O)=O)=O)=O)=O)CO2
8300-8SSMG_02538M6
N-Hydroxy-N-formyl-ornithine;300-7
from: 300-7
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(N[C@@H](CC)C(N[C@H](CCCN(C(C)=O)O)C(O)=O)=O)=O)=O)=O)CO2
9300-9SSMG_02537M7
N-Hydroxy-ornithine;300-8
from: 300-8
OC1=CC=CC=C1C2=N[C@@H](C(N[C@@H](CO)C(N[C@H](CO)C(N[C@@H](CC)C(N[C@H](CCCN(C([H])=O)O)C(N[C@H](CCCNO)C(O)=O)=O)=O)=O)=O)=O)CO2
10300SSMG_02540TE
300-9
from: 300-9
O=C1[C@H](NC([C@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@H]2COC(C3=CC=CC=C3O)=N2)=O)CO)=O)CO)=O)CO)=O)CCCN(O)C=O)=O)CCCN1O
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture