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BGC0000291NRPS

A54145

Producing organism
Streptomyces fradiae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map60 genes · 126,933 bp

20 kb126.9 kb visible · 126,933 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
CALCoA-ligase (CAL)
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

15 steps · 13 edges
Step 1
start
+decanoyl-CoA
Step 15TE
lptD
Step 2M1
lptA
+Tryptophan
Step 3M2
lptA
+Glutamic acid
Step 4M3
lptA
+hydroxy Asparagine
Step 5M4
lptA
+Threonine
Step 6M5
lptA
+Sarcosine
Step 7M6
lptB
+Alanine
Step 8M7
lptB
+Aspartic acid
Step 9M8
lptC
+Lysine
Step 10M9
lptC
+methoxy-Aspartic …
Step 11M10
lptC
+Glycine
Step 12M11
lptC
+Asparagine
Step 13M12
lptD
+3-methoxy-Glutami…
Step 14M13
lptD
+Isoleucine
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1291-1start—
decanoyl-CoA
O=C(CCCCCCCCC)O—
2291-2lptAM1
291-1;Tryptophan
from: 291-1
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O—
3291-3lptAM2
291-2;Glutamic acid
from: 291-2
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(O)=O)=O—
4291-4lptAM3
291-3;hydroxy Asparagine
from: 291-3
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(O)=O)=O)=O—
5291-5lptAM4
291-4;Threonine
from: 291-4
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(O)=O)=O)=O)=O—
6291-6lptAM5
291-5;Sarcosine
from: 291-5
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(O)=O)=O)=O)=O)=O—
7291-7lptBM6
291-6;Alanine
from: 291-6
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(N[C@H](C(O)=O)C)=O)=O)=O)=O)=O—
8291-8lptBM7
291-7;Aspartic acid
from: 291-7
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)C)=O)=O)=O)=O)=O—
9291-9lptCM8
291-8;Lysine
from: 291-8
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](CCCCN)C(O)=O)=O)=O)C)=O)=O)=O)=O)=O—
10291-10lptCM9
291-9;methoxy-Aspartic acid
from: 291-9
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@@H]([C@@H](C(O)=O)OC)C(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O—
11291-11lptCM10
291-10;Glycine
from: 291-10
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@@H]([C@@H](C(O)=O)OC)C(NCC(O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O—
12291-12lptCM11
291-11;Asparagine
from: 291-11
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@@H]([C@@H](C(O)=O)OC)C(NCC(N[C@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O—
13291-13lptDM12
291-12;3-methoxy-Glutamic acid
from: 291-12
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@@H]([C@@H](C(O)=O)OC)C(NCC(N[C@H](CC(N)=O)C(NC(C(O)=O)[C@@H](C)CC(O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O—
14291-14lptDM13
291-13;Isoleucine
from: 291-13
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H](C(O)C)C(N(C)CC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@@H]([C@@H](C(O)=O)OC)C(NCC(N[C@H](CC(N)=O)C(NC(C(N[C@@H]([C@H](C)CC)C(O)=O)=O)[C@@H](C)CC(O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O—
15291lptDTE
O=C(CCCCCCCCC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](CCC(O)=O)C(N[C@@H]([C@H](O)C(N)=O)C(N[C@@H]3C(N(C)CC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@@H]([C@@H](C(O)=O)OC)C(NCC(N[C@H](CC(N)=O)C(NC(C(N[C@@H]([C@H](C)CC)C(O[C@@H]3C)=O)=O)[C@@H](C)CC(O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O—
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