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BGC0000288NRPS

A-503083 A;A-503083 B;A-503083 E;A-503083 F

Producing organism
Streptomyces sp. SANK 62799
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
12
DOI
MIBiG entry
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C25H34N6O13626.22 Da

Gene Cluster Map55 genes · 80,953 bp

A20 kb81.0 kb visible · 80,953 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
ACPAcyl carrier (ACP)
TauDTauD oxygenase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

12 steps · 12 edges
Step 1
start
+Mannose-1-phospha…
Step 2
start
+Phosphoenolpyruva…
Step 3
start
+Uridine
Step 4
start
+AdoMet
Step 5
start
+Carbomoyl-phospha…
Step 8
start
+L-Lysine
Step 6
?,capK,capB
Step 9
capU,capV
Step 7
capS
+288(1)
Step 12
?
+288(1)
Step 10
capW
Step 11
?
+288(2)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1288-1start—
Mannose-1-phosphate
O[C@@H]1[C@H](O)[C@@H](O[P])O[C@H](CO)[C@H]1O—
2288-2start—
Phosphoenolpyruvate
C=C(O[P])C(O)=O—
3288-3start—
Uridine
O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)NC1=O—
4288-4start—
AdoMet
OC([C@@H](N)CC[S](C)C[C@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O1)=O—
5288-5start—
Carbomoyl-phosphate
NC(OP(O)(O)=O)=O—
6288(1)?,capK,capB—
288-1;288-2;288-3;288-4;288-5
from: 288-1, 288-2, 288-3, 288-4, 288-5
O=C(C=CN1[C@H]2[C@H](OC(N)=O)[C@H](OC)[C@]([C@H](C(N)=O)O[C@@H]3OC(C(O)=O)=C[C@H](O)[C@@H]3O)([H])O2)NC1=O—
7288-6capS—
288(1);288-4
from: 288-4
O=C(C=CN1[C@H]2[C@H](OC(N)=O)[C@H](OC)[C@]([C@H](C(N)=O)O[C@@H]3OC(C(OC)=O)=C[C@H](O)[C@@H]3O)([H])O2)NC1=O—
8288-7start—
L-Lysine
NCCCC[C@H](N)C(O)=O—
9288-8capU,capV—
288-7
from: 288-7
O=C1[C@@H](N)CCCCN1—
10288(2)capW—
288-6;288-8
from: 288-6, 288-8
O=C(C=CN1[C@H]2[C@H](OC(N)=O)[C@H](OC)[C@]([C@H](C(N)=O)O[C@@H]3OC(C(N[C@H]4CCCC([H])NC4=O)=O)=C[C@H](O)[C@@H]3O)([H])O2)NC1=O—
11288(3)?—
288(2)
O=C(C=CN1[C@H]2[C@H](OC(N)=O)[C@H](OC)[C@]([C@H](C(N)=O)O[C@@H]3OC(C(N[C@H]4CCC[C@@H](C)NC4=O)=O)=C[C@H](O)[C@@H]3O)([H])O2)NC1=O—
12288(4)?—
288(1)
O=C(C=CN1[C@H]2[C@H](OC(N)=O)[C@H](OC)[C@]([C@H](C(N)=O)O[C@@H]3OC(C(OC)=O)=C[C@H](O)[C@@H]3O)([H])O2)NC1=O—
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