NPdia

BGC0000204PKS

benastatin A;benastatin B;BE-43767;TAN1532B

Producing organism: Streptomyces sp. A2991200
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Type II)
Total steps: 8
DOI: 10.1016/j.bioorg.2024.107572.
MIBiG entry: View on MIBiG ↗

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C₃₀H₂₈O₇500.18 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Polyketide cyclase

8 steps · 7 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`204-1`	start	—		`CCCC(O)=O`	—
2	`204-2`	benQ	—	204-1;Malonyl-CoA from: 204-1	`OC(CCCCC)=O`	—
3	`204-3`	benA,benB,benC	—	204-2;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA from: 204-2	`OC(CC(CC(CC(CC(CC(CC(CC(CC(CC(O)CC(CC(CC(CCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O`	{'iteration': [((None), ‘Mal…
4	`204-4`	benE,benD,benH,benJ,benM	—	204-3 from: 204-3	`OC(C1=C(O)C2=C(C=C1CCCCC)C=CC(C2=C3)=C(O)C4=C3CC5=CC(O)=CC(O)=C5C4=O)=O`	—
5	`204(1)`	benF	—	204-4 from: 204-4	`OC(C1=C(O)C2=C(C=C1CCCCC)C=CC(C2=C3)=C(O)C4=C3C(C)(C)C5=CC(O)=CC(O)=C5C4=O)=O`	—
6	`204(2)`	benF	—	204-4 from: 204-4	`OC(C1=C(O)C2=C(C([H])=C1CCCCC)CCC(C2=C3)=C(O)C4=C3C(C)(C)C5=CC(O)=CC(O)=C5C4=O)=O`	—
7	`204(3)`	benF	—	204-4 from: 204-4	`OC(C1=C(O)C2=C(C=C1CCCCC)C=CC(C2=C3)=C(O)C4=C3C(O)(C)C5=CC(O)=CC(O)=C5C4=O)=O`	—
8	`204(4)`	benF	—	204-4 from: 204-4	`OC(C1=C(O)C2=C(C=C1CCCCC)CCC(C2=C3)=C(O)C4=C3C(O)(C)C5=CC(O)=CC(O)=C5C4=O)=O`	—

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