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BGC0000203PKS

BE-7585A

Producing organism
Amycolatopsis orientalis subsp. vinearia
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
PKS (unknown)
Total steps
28
DOI
MIBiG entry
View on MIBiG ↗
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BE-7585A
C37H46O20S842.23 Da

Gene Cluster Map42 genes · 48,405 bp

KSKS10 kb48.4 kb visible · 48,405 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
CycPolyketide cyclase
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

28 steps · 26 edges
Step 1
start
+2-thioglucose
Step 3
start
+Glucosinolates
Step 5
start
+Glucose 1-phospha…
Step 14
start
+Acetyl-CoA
Step 2
?
+ATP
Step 6
bexU
Step 15
bexA,bexB,bexC
+Malonyl-CoA, Malonyl-CoA
{'iteration': [((None), ‘M…
Step 4
bexG2
Step 7
bexS
Step 16
bexD,bexL
Step 8
bexV
Step 17
bexF
Step 24
?
Step 9
bexQ
Step 18
bexI,bexE
Step 10
bexT,bexO
Step 19
?
Step 11
bexH
Step 20
?
Step 12
?
Step 21
bexM
Step 13
bexG1
Step 22
?
Step 23
bexK
Step 25
?
Step 26
?
Step 27
?
Step 28
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions28 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1203-1start—
2-thioglucose
O[C@H]1[C@H](O)[C@@H](S)C(O)O[C@@H]1CO—
2203-2?—
203-1;ATP
from: 203-1
O[C@H]1[C@H](O)[C@@H](S)C(O)O[C@@H]1COP([O-])([O-])=O—
3203-3start—
Glucosinolates
O[C@H]1[C@H](O)[C@@H](O)C([R])O[C@@H]1CO—
4203-4bexG2—
203-2;203-3
from: 203-2, 203-3
S[C@H]1[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@@H]1O—
5203-5start—
Glucose 1-phosphate
O[C@H]1[C@H](O)[C@@H](O)C(OP([O-])([O-])=O)O[C@@H]1CO—
6203-6bexU—
203-5
from: 203-5
O[C@H]1[C@H](O)[C@@H](O)C([R])O[C@@H]1CO—
7203-7bexS—
203-6
from: 203-6
O[C@H]([C@@H](O)C([R])O[C@@H]1C)C1=O—
8203-8bexV—
203-7
from: 203-7
O=C(CC([R])O[C@@H]1C)C1=O—
9203-9bexQ—
203-8
from: 203-8
O[C@H](CC([R])O[C@@H]1C)C1=O—
10203-10bexT,bexO—
203-9
from: 203-9
[R]C(O[C@@H]1C)CCC1=O—
11203-11bexH—
203-10
from: 203-10
O=C1[C@H](C)O[C@H]([R])CC1—
12203-12?—
203-11
from: 203-11
[R][C@@H]1CC[C@H](O)[C@H](C)O1—
13203-13bexG1—
203-12
from: 203-12
O[C@@H]1[C@H](C)O[C@@H](OC)CC1—
14203-14start—
Acetyl-CoA
OC(C)=O—
15203-15bexA,bexB,bexC—
203-14;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
from: 203-14
O=C(CC(CC(CC(CC(O)=O)=O)=O)=O)CC(CC(CC(CC(CC(C)=O)=O)=O)=O)=O{'iteration': [((None), ‘Mal…
16203-16bexD,bexL—
203-15
from: 203-15
OC1=CC=CC2=C1C(C(C(CC(CC(C)=O)=O)=O)=C(CC(CC(O)=O)=O)C2)=O—
17203-17bexF—
203-16
from: 203-16
OC1=CC=CC2=C1C(C(C(C(C3(O)C4)C(CC(O)(C)C3)=O)=O)=C4C2)=O—
18203-18bexI,bexE—
203-17
from: 203-17
OC1=CC=CC2=C1C(C(C(C(OC(CC(O)(C)C3)=O)C3(O)C4)=O)=C4C2=O)=O—
19203-19?—
203-18
from: 203-18
OC1=CC=CC2=C1C(C(C(C(O)C(O)(CC(O)(C)CC(O)=O)C3)=O)=C3C2=O)=O—
20203-20?—
203-19
from: 203-19
OC1=CC=CC2=C1C(C(C(C(O)C(CC(O)(C)C3)(O)C4C3=O)=O)=C4C2=O)=O—
21203-21bexM—
203-20
from: 203-20
OC1=CC=CC2=C1C(C(C=CC(O)(CC(O)(C)C3)C4OC3=O)=C4C2=O)=O—
22203-22?—
203-21
from: 203-21
OC1=CC=CC2=C1C(C(C=CC(O)(CC(O)(C)C3)C4(O)C3=O)=C4C2=O)=O—
23203-23bexK—
203-22
from: 203-22
OC1=CC=CC2=C1C(C(C=CC(O)(CC(O)(C)C3O)C4(O)C3=O)=C4C2=O)=O—
24203-24?—
203-4
from: 203-4
S[C@H]1[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@H](CO)[C@@H](O)[C@@H]1O—
25203-25?—
203-23;203-24
from: 203-23, 203-24
OC1=CC=CC2=C1C(C3=CC([H])(S[C@H]4[C@@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)C(O)(CC(O)(C)C(O)C6=O)C6(O)C3=C2=O)=O—
26203-26?—
203-25
from: 203-25
OC1=CC=CC2=C1C(O)=C(C=C(S[C@H]3[C@@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)C(O)(CC(O)(C)C5O)C6(O)C5=O)C6=C2O—
27203-27?—
203-26
from: 203-26
OC1=CC=CC2=C1C(C(C=C(S[C@H]3[C@@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)C(O)(CC(O)(C)C5O)C6(O)C5=O)=C6C2=O)=O—
28203?—
203-27
from: 203-27
OC1=CC=CC2=C1C(C(C=C(S[C@H]3[C@@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)C(O)(CC(O)(C)C5O)C6(O[C@@H]7O[C@@H](C)[C@@H](O)CC7)C5=O)=C6C2=O)=O—
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