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BGC0000177PKS

Iso-migrastatin;Migrastatin;Dorrigocin A;Dorrigocin B;13-epi-dorrigocin A

Producing organism
Streptomyces platensis subsp. rosaceus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
23
DOI
MIBiG entry
View on MIBiG ↗
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C27H39NO7489.27 Da

Gene Cluster Map11 genes · 53,336 bp

ATKSKSKSKSKSKSKSKSKSKSTEAT10 kb53.3 kb visible · 53,336 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase
ACPβACP (β-branching)

Pathway Graphsteps arranged in biosynthetic order

23 steps · 13 edges
Step 1Load
ACY01388.1;ACY01389.1
Step 2M2
ACY01390.1
Trans-AT
Step 3M3
ACY01390.1
Trans-AT
Step 4M4
ACY01390.1;ACY01391.1
Trans-AT
Step 5M5
ACY01391.1
Trans-AT
Step 6M6
ACY01391.1
Trans-AT
Step 7M7
ACY01391.1
Trans-AT
Step 8M8
ACY01391.1
Trans-AT
Step 9M9
ACY01391.1
Inactive: ACY01393.1, Malonyl-CoA
Step 10M10
ACY01391.1;ACY01392.1
Trans-AT
Step 11M11
ACY01392.1
Trans-AT
Step 12TE
ACY01392.1
Step 13
ACY01396.1
Step 14
ACY01394.1
Step 15
ACY01395.1
Step 16
ACY01394.1
Step 17
ACY01396.1
Step 18
ACY01394.1
Step 19
ACY01395.1
Step 20
?
+177(1)
Step 21
?
+177(1)
Step 22
?
+177(1)
Step 23
?
+177(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions23 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1177-1ACY01388.1;ACY01389.1Loading
O=C(O)CC(N)=O—
2177-2ACY01390.1M2
O=C(C/C=C/C(O)=O)N{'transAT': ['ACY01393.1', '…
3177-3ACY01390.1M3
O=C1NC(CC(CC(O)=O)C1)=O{'transAT': ['ACY01393.1', '…
4177-4ACY01390.1;ACY01391.1M4
OC(/C=C/CC(CC(N1)=O)CC1=O)=O{'transAT': ['ACY01393.1', '…
5177-5ACY01391.1M5
O=C(C(C)C(O)=O)/C=C/CC(CC(N1)=O)CC1=O{'transAT': ['ACY01393.1', '…
6177-6ACY01391.1M6
O=C(C(C)/C=C(C)/C(O)=O)/C=C/CC(CC(N1)=O)CC1=O{'transAT': ['ACY01393.1', '…
7177-7ACY01391.1M7
O=C(C(C)/C=C(C)/C(O)C(C)C(O)=O)/C=C/CC(CC(N1)=O)CC1=O{'transAT': ['ACY01393.1', '…
8177-8ACY01391.1M8
O=C(C(C)/C=C(C)/C(O)C(C)C(O)CC(O)=O)/C=C/CC(CC(N1)=O)CC1=O{'transAT': ['ACY01393.1', '…
9177-9ACY01391.1M9
O=C(C(C)/C=C(C)/C(O)C(C)C(O)C/C=C/C(O)=O)/C=C/CC(CC(N1)=O)CC1=O{'transAT': ['ACY01393.1', '…
10177-10ACY01391.1;ACY01392.1M10
O=C(C(C)/C=C(C)/C(O)C(C)C(O)C/C=C/CCC(O)=O)/C=C/CC(CC(N1)=O)CC1=O{'transAT': ['ACY01393.1', '…
11177-11ACY01392.1M11
177-10
from: 177-10
O=C(C(C)/C=C(C)/C(O)C(C)C(O)C/C=C/CC/C=C/C(O)=O)/C=C/CC(CC(N1)=O)CC1=O{'transAT': ['ACY01393.1', '…
12177-12ACY01392.1TE
177-11
from: 177-11
C[C@H]([C@H](C(C[C@@H](C(/C=C/CC1CC(NC(C1)=O)=O)=O)C)C)O2)[C@H](O)C/C=C/CC/C=C/C2=O—
13177-13ACY01396.1—
177-12
from: 177-12
C[C@H]([C@H](C(C[C@@H](C(/C=C/CC1CC(NC(C1)=O)=O)=O)C)C)O2)[C@H](O)[C@@H](O)/C=C/CC/C=C/C2=O—
14177-14ACY01394.1—
177-12
from: 177-12
C[C@H]([C@H](C(C[C@@H](C(CCCC1CC(NC(C1)=O)=O)=O)C)C)O2)[C@H](O)C/C=C/CC/C=C/C2=O—
15177-15ACY01395.1—
177-13
from: 177-13
C[C@H]([C@H](C(C[C@@H](C(/C=C/CC1CC(NC(C1)=O)=O)=O)C)C)O2)[C@H](O)[C@@H](OC)/C=C/CC/C=C/C2=O—
16177-16ACY01394.1—
177-13
from: 177-13
C[C@H]([C@H](C(C[C@@H](C(CCCC1CC(NC(C1)=O)=O)=O)C)C)O2)[C@H](O)[C@@H](O)/C=C/CC/C=C/C2=O—
17177-16ACY01396.1—
177-14
from: 177-14
C[C@H]([C@H](C(C[C@@H](C(CCCC1CC(NC(C1)=O)=O)=O)C)C)O2)[C@H](O)[C@@H](O)/C=C/CC/C=C/C2=O—
18177-17ACY01394.1—
177-15
from: 177-15
C[C@H]([C@H](C(C[C@@H](C(CCCC1CC(NC(C1)=O)=O)=O)C)C)O2)[C@H](O)[C@@H](OC)/C=C/CC/C=C/C2=O—
19177(1)ACY01395.1—
177-16
from: 177-16
C[C@H]([C@H](C(C[C@@H](C(CCCC1CC(NC(C1)=O)=O)=O)C)C)O2)[C@H](O)[C@@H](OC)/C=C/CC/C=C/C2=O—
20177(2)?—
177(1)
C[C@H]1[C@H](O)[C@@H](OC)/C=C/CC/C=C/C(OC(C(C)C(CCCC2CC(NC(C2)=O)=O)C)/C(C)=C\1)=O—
21177(3)?—
177(1)
C[C@H](/C=C([C@H](O)[C@@H](C(CC1CC(NC(C1)=O)=O)=O)C)\C)[C@H](O)[C@@H](OC)/C=C/CC/C=C/C(O)=O—
22177(4)?—
177(1)
C[C@H](/C=C([C@@H](O)[C@@H](C(CC1CC(NC(C1)=O)=O)=O)C)\C)[C@H](O)[C@@H](OC)/C=C/CC/C=C/C(O)=O—
23177(5)?—
177(1)
C[C@H]([C@@H](O)/C(C)=C/[C@@H](C(CC1CC(NC(C1)=O)=O)=O)C)[C@H](O)[C@@H](OC)/C=C/CC/C=C/C(O)=O—
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