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BGC0000175PKS

Cycloheximide

Producing organism
Streptomyces sp. YIM 56141
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Trans-AT type I)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
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cycloheximide
C15H23NO4281.16 Da

Gene Cluster Map18 genes · 45,467 bp

ATKSDH2KSKSKSKSDH2MTATD10 kb45.5 kb visible · 45,467 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase
TDTerminal reductase

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1M1
AFO59864.1;AFO59865.1
Step 2M2
AFO59866.1
Trans-AT
Step M3
AFO59866.1
Trans-AT
Step M4
AFO59866.1
Trans-AT
Step M5
AFO59866.1
Trans-AT
Step M6
AFO59866.1
Iterative
Step TE
AFO59866.1
Step
AFO59871.1
Step
?
Step
?
Step
AFO59868.1
Step
AFO59869.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1175-1AFO59864.1;AFO59865.1M1
O=C(CC(N)=O)O—
2175-2AFO59866.1M2
175-1
from: 175-1
O=C(N)C/C=C/C(O)=O{'transAT': ['AFO59863.1', '…
175-3AFO59866.1M3
175-2
from: 175-2
O=C(O)CC(CC(N1)=O)CC1=O{'transAT': ['AFO59863.1', '…
175-4AFO59866.1M4
175-3
from: 175-3
O[C@@H](CC(O)=O)CC(CC(N1)=O)CC1=O{'transAT': ['AFO59863.1', '…
175-5AFO59866.1M5
175-4
from: 175-4
O[C@@H](CC(CC(O)=O)=O)CC(CC(N1)=O)CC1=O{'transAT': ['AFO59863.1', '…
175-6AFO59866.1M6
175-5
from: 175-5
O[C@@H](CC([C@@H](C)/C=C(C(O)=O)\C)=O)CC(CC(N1)=O)CC1=O{'transAT': ['AFO59863.1', '…
175-7AFO59866.1TE
175-6
from: 175-6
O[C@@H](CC([C@@H](C)/C=C(C(O)=O)\C)=O)CC(CC(N1)=O)CC1=O—
175-8AFO59871.1—
175-7
from: 175-7
O[C@@H](CC([C@@H](C)/C=C(C)\C([H])=O)=O)CC(CC(N1)=O)CC1=O—
175-9?—
175-8
from: 175-8
O=C(C1C([C@@H](C)C=C(C)C1O)=O)CC(CC(N2)=O)CC2=O—
175-10?—
175-9
from: 175-9
O=C(C1=CC(C)=CC(C)=C1O)CC(CC(N2)=O)CC2=O—
175-11AFO59868.1—
175-10
from: 175-10
O=C(C1=C([C@@H](C)C[C@H](C)C1)O)CC(CC(N2)=O)CC2=O—
175AFO59869.1—
175-11
from: 175-11
O=C([C@](C([C@@H](C)C1)=O)([H])C[C@H]1C)CC(CC(N2)=O)CC2=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture