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BGC0000167PKS

Vicenistatin

Producing organism
Streptomyces halstedii
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
27
DOI
MIBiG entry
View on MIBiG ↗
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vicenistatin
C30H48N2O4500.36 Da

Gene Cluster Map20 genes · 64,492 bp

KSATERKSKSATKSKSAAKSERKSKSAT10 kb64.5 kb visible · 64,492 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

27 steps · 26 edges
Step 1
Start
Step 16
Start
Step 2
vinH, vinI
Step 17
vinA
Step 3(1)
vinN
Step 3(2)
vinM/vinN
Step 18
vinB
Step 4(1)(1)
vinO
Step 4(2)
?
Step 4(1)(2)
vinK
Step 19
vinD
Step 5(1)
vinK
Step 5(2)
vinO
Step 20
vinE
Step 6Load
vinP1
Step 21
vinF
Step 7M1
vinP1
+Malonyl-CoA
Step 22
vinG
Step 8M2
vinP1
+Malonyl-CoA
Step 9M3
vinP1
+Methylmalonyl-CoA
Step 10M4
vinP2
+Methylmalonyl-CoA
Step 11M5
vinP3
+Malonyl-CoA
Step 12M6
vinP3
+Methylmalonyl-CoA
Step 13M7
vinP4
+Malonyl-CoA
Step 14M8
vinP4
+Malonyl-CoA
Step 15TE
vinP4
Step 23
vinC
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions27 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1167-1Start—
N[C@H](C(O)=O)CCC(O)=O—
2167-2vinH, vinI—
167-1
from: 167-1
N[C@H](C(O)=O)[C@H](C)C(O)=O—
3(1)167-3vinN—
167-2
from: 167-2
N[C@H](C(O)=O)[C@H](C)C([R])=O—
4(1)(1)167-4vinO—
167-3
from: 167-3
NC[C@@H](C)C([R])=O—
3(2)167-5vinM/vinN—
167-2
from: 167-2
N[C@H](C(O)=O)[C@H](C)C([R])=O—
4(2)167-6?—
167-5
from: 167-5
N[C@H](C(O)=O)[C@H](C)C(O)=O—
4(1)(2)167-6vinK—
167-3
from: 167-3
N[C@H](C(O)=O)[C@H](C)C(O)=O—
5(1)167-7vinK—
167-4
from: 167-4
NC[C@@H](C)C(O)=O—
5(2)167-7vinO—
167-6
from: 167-6
NC[C@@H](C)C(O)=O—
6167-8vinP1Loading
167-7
from: 167-7
O=C(O)[C@@H](CN)C—
7167-9vinP1M1
167-8;Malonyl-CoA
from: 167-8
C[C@H](CN)CCC(O)=O—
8167-10vinP1M2
167-9;Malonyl-CoA
from: 167-9
C[C@H](CN)CC/C=C/C(O)=O—
9167-11vinP1M3
167-10;Methylmalonyl-CoA
from: 167-10
C[C@H](CN)CC/C=C/C=C(C(O)=O)\C—
10167-12vinP2M4
167-11;Methylmalonyl-CoA
from: 167-11
C[C@H](CN)CC/C=C/C=C(CC(C(O)=O)C)\C—
11167-13vinP3M5
167-12;Malonyl-CoA
from: 167-12
C[C@H](CN)CC/C=C/C=C(C/C(C)=C/CC(O)=O)\C—
12167-14vinP3M6
167-13;Methylmalonyl-CoA
from: 167-13
C[C@H](CN)CC/C=C/C=C(C/C(C)=C/C[C@H](O)[C@H](C(O)=O)C)\C—
13167-15vinP4M7
167-14;Malonyl-CoA
from: 167-14
C[C@H](CN)CC/C=C/C=C(C/C(C)=C/C[C@H](O)[C@H](/C=C/C(O)=O)C)\C—
14167-16vinP4M8
167-15;Malonyl-CoA
from: 167-15
C[C@H](CN)CC/C=C/C=C(C/C(C)=C/C[C@H](O)[C@H](/C=C/C=C/C(O)=O)C)\C—
15167-17vinP4TE
167-16
from: 167-16
C/C(C/C(C)=C/C[C@H](O)[C@@H](C)/C=C/C=C/1)=C\C=C\CC[C@H](C)CNC1=O—
16167-18Start—
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
17167-19vinA—
167-18
from: 167-18
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
18167-20vinB—
167-19
from: 167-19
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1C)C1=O—
19167-21vinD—
167-20
from: 167-20
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
20167-22vinE—
167-21
from: 167-21
[R][C@@H](O[C@@H]1C)C[C@H](O)C1=O—
21167-23vinF—
167-22
from: 167-22
[R][C@@H]1C[C@H](O)[C@H](N)[C@@H](C)O1—
22167-24vinG—
167-23
from: 167-23
[R][C@@H]1C[C@H](O)[C@H](N(C)C)[C@@H](C)O1—
23167vinC—
167-17;167-24
from: 167-17, 167-24
C/C(C/C(C)=C/C[C@H](O[C@H]1C[C@H](O)[C@H](N(C)C)[C@@H](C)O1)[C@@H](C)/C=C/C=C/2)=C\C=C\CC[C@H](C)CNC2=O—
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