NPdia

BGC0000166PKS

Tylactone

Producing organism: Streptomyces fradiae
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Unknown)
Total steps: 9
DOI: 10.1186/s12934-019-1184-z 10.1021/ja804453p
MIBiG entry: View on MIBiG ↗

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tylactone

C₂₃H₃₈O₅394.27 Da

Biosynthetic (core)

Biosynthetic (additional)

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Thioesterase (TE)

Docking N-term

Docking C-term

Dehydratase (DHt)

9 steps · 8 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`166-1`	tylG	Loading	Methylmalonyl-CoA	`O=C(CC)O`	—
2	`166-2`	tylG	M1	166-1;Methylmalonyl-CoA from: 166-1	`O[C@H](CC)[C@@H](C)C(O)=O`	—
3	`166-3`	tylG	M2	166-2;Methylmalonyl-CoA from: 166-2	`O[C@H](CC)[C@@H](C)/C=C(C)/C(O)=O`	—
4	`166-4`	tylG_rename1	M3	166-3;Malonyl-CoA from: 166-3	`O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C(O)=O`	—
5	`166-5`	tylG_rename2	M4	166-4;Methylmalonyl-CoA from: 166-4	`O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C([C@@H](C(O)=O)C)=O`	—
6	`166-6`	tylG_rename2	M5	166-5;Ethylmalonyl-CoA from: 166-5	`O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C([C@@H](C[C@@H](C(O)=O)CC)C)=O`	—
7	`166-7`	tylG_rename3	M6	166-6;Methylmalonyl-CoA from: 166-6	`O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C([C@@H](C[C@@H]([C@H](O)[C@H](C(O)=O)C)CC)C)=O`	—
8	`166-8`	tylG_rename4	M7	166-7;Malonyl-CoA from: 166-7	`O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C([C@@H](C[C@@H]([C@H](O)[C@H]([C@H](O)CC(O)=O)C)CC)C)=O`	—
9	`166`	tylG_rename4	TE	166-8 from: 166-8	`O=C(/C=C/C(C)=C/C(C)[C@@H](CC)O1)[C@H](C)C[C@H](CC)[C@H](O)[C@@H](C)[C@H](O)CC1=O`	—

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