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BGC0000164PKS

Tetronomycin

Producing organism
Streptomyces sp. NRRL 11266
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
22
DOI
MIBiG entry
View on MIBiG ↗
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tetronomycin
C34H49NaO8608.33 Da

Gene Cluster Map33 genes · 113,234 bp

20 kb113.2 kb visible · 113,234 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
TdTrans-AT docking
MTMethyltransferase
ACPSACP synthase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

22 steps · 21 edges
Step 1Load
tmnA1
+Malonyl-CoA
Step 16
Start
Step 2M1
tmnA1
+malonyl-CoA
Step 17
tmn7a, tmn16
Step 3M2
tmnA1
+malonyl-CoA
Step 4M3
tmnAII
+malonyl-CoA
Step 5M4
tmnAIII
+malonyl-CoA
Step 6M5
tmnAIII
+malonyl-CoA
Step 7M6
tmnAIV
+Methylmalonyl-CoA
Step 8M7
tmnAIV
+Methylmalonyl-CoA
Step 9M8
tmnAIV
+malonyl-CoA
Step 10M9
tmnAV
+malonyl-CoA
Step 11M10
tmnAV
+Methylmalonyl-CoA
Step 12M11
tmnAV
+Methylmalonyl-CoA
Step 13M12
tmnVI
+malonyl-CoA
Inactive: KR
Step 14
?
Step 15
?
Step 18
tmn7?, tmn15?, tmn17?
Step 19
tmn9?, tmn8?
Step 20
tmnC
Step 21
tmnB
Step 22
tmn12, tmn14/tmn14a
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1164-1tmnA1Loading
Malonyl-CoA
O=C(C)O—
2164-2tmnA1M1
164-1;malonyl-CoA
from: 164-1
C/C=C/C(O)=O—
3164-3tmnA1M2
164-2;malonyl-CoA
from: 164-2
C/C=C/CCC(O)=O—
4164-4tmnAIIM3
164-3;malonyl-CoA
from: 164-3
C/C=C/CC[C@H](O)CC(O)=O—
5164-5tmnAIIIM4
164-4;malonyl-CoA
from: 164-4
C/C=C/CC[C@H](O)C/C=C/C(O)=O—
6164-6tmnAIIIM5
164-5;malonyl-CoA
from: 164-5
C/C=C/CC[C@H](O)C/C=C/[C@H](O)CC(O)=O—
7164-7tmnAIVM6
164-6;Methylmalonyl-CoA
from: 164-6
C/C=C/CC[C@H](O)C/C=C/[C@H](O)CC[C@H](C)C(O)=O—
8164-8tmnAIVM7
164-7;Methylmalonyl-CoA
from: 164-7
C/C=C/CC[C@H](O)C/C=C/[C@H](O)CC[C@H](C)/C=C(C)/C(O)=O—
9164-9tmnAIVM8
164-8;malonyl-CoA
from: 164-8
C/C=C/CC[C@H](O)C/C=C/[C@H](O)CC[C@H](C)/C=C(C)/C=C/C(O)=O—
10164-10tmnAVM9
164-9;malonyl-CoA
from: 164-9
C/C=C/CC[C@H](O)C/C=C/[C@H](O)CC[C@H](C)/C=C(C)/C=C/CCC(O)=O—
11164-11tmnAVM10
164-10;Methylmalonyl-CoA
from: 164-10
C/C=C/CC[C@H](O)C/C=C/[C@H](O)CC[C@H](C)/C=C(C)/C=C/CCC[C@H](C)C(O)=O—
12164-12tmnAVM11
164-11;Methylmalonyl-CoA
from: 164-11
C/C=C/CC[C@H](O)C/C=C/[C@H](O)CC[C@H](C)/C=C(C)/C=C/CCC[C@H](C)/C=C(C)/C(O)=O—
13164-13tmnVIM12
164-12;malonyl-CoA
from: 164-12
C/C=C/CC[C@H](O)C/C=C/[C@H](O)CC[C@H](C)/C=C(C)/C=C/CCC[C@H](C)/C=C(C)/C(CC(O)=O)=O{'Inactive': ['KR']}
14164-14?—
164-13
from: 164-13
C/C=C/CC[C@H](O)C/C=C/[C@@H](CC[C@@H](/C=C(\C=C\CCC[C@@H](/C=C(C)\C(CC(O)=O)=[OH+])C)C)C)O—
15164-15?—
164-14
from: 164-14
C/C=C/CC[C@H](O)C/C=C/[C@]1([H])O[C@@](/C(C)=C/[C@]2([H])CCC[C@@H]([C@@]2([H])[C@@H](C)/C(O)=C\C(O)=O)C)([H])[C@@H](C)CC1—
16164-16Start—
O[C@@H](C(OP(O)(O)=O)=O)COP(O)(O)=O—
17164-17tmn7a, tmn16—
164-16
from: 164-16
O[C@@H](C(O)=O)CO—
18164-18tmn7?, tmn15?, tmn17?—
164-15;164-17
from: 164-15, 164-17
C/C=C/CC[C@H](O)C/C=C/[C@]1([H])O[C@@](/C(C)=C/[C@]2([H])CCC[C@@H]([C@@]2([H])[C@@H](C)/C([O-])=C3C(O[C@H](CO)C\3=O)=O)C)([H])[C@@H](C)CC1.[Na+]—
19164-19tmn9?, tmn8?—
164-18
from: 164-18
C/C=C/CC[C@H](O)C/C=C/[C@]1([H])O[C@@](/C(C)=C/[C@]2([H])CCC[C@@H]([C@@]2([H])[C@@H](C)/C([O-])=C(C3=O)\C(OC3=C)=O)C)([H])[C@@H](C)CC1.[Na+]—
20164-20tmnC—
164-19
from: 164-19
C[C@H]1[C@@H](O1)CC[C@H](O)C/C=C/[C@]2([H])O[C@@](/C(C)=C/[C@]3([H])CCC[C@@H]([C@@]3([H])[C@@H](C)/C([O-])=C(C4=O)\C(OC4=C)=O)C)([H])[C@@H](C)CC2.[Na+]—
21164-21tmnB—
164-20
from: 164-20
C[C@H]1CC[C@](O[C@]1([H])/C(C)=C/[C@]2([H])CCC[C@@H]([C@@]2([H])[C@@H](C)/C([O-])=C(C3=O)\C(OC3=C)=O)C)([H])/C=C/C[C@@]4([H])O[C@@]([C@](C)([H])O)([H])CC4.[Na+]—
22164tmn12, tmn14/tmn14a—
164-21
from: 164-21
C[C@H]1CC[C@](O[C@]1([H])/C(C)=C/[C@]2([H])CCC[C@@H]([C@@]2([H])[C@@H](C)/C([O-])=C(C3=O)\C(OC3=C)=O)C)([H])/C=C/C[C@@]4([H])O[C@@]([C@](C)([H])OC)([H])CC4.[Na+]—
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