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BGC0000163PKS

Tetronasin

Producing organism
Streptomyces longisporoflavus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗
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tetronasin
C35H54O8602.38 Da

Gene Cluster Map52 genes · 169,690 bp

20 kb169.7 kb visible · 169,690 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
TdTrans-AT docking
MTMethyltransferase
CALCoA-ligase (CAL)
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1Load
tsnAI
+Malonyl-CoA
Step 2M1
tsnAI
+Malonyl-CoA
Step 3M2
tsnAI
+Methylmalonyl-CoA
Step 4M3
tsnAII
+Methylmalonyl-CoA
Inactive: DH
Step 5M4
tsnAII
+Malonyl-CoA
Step 6M5
tsnAII
+Malonyl-CoA
Step 7M6
tsnAIII
+Methylmalonyl-CoA
Step 8M7
tsnAIII
+Hydroxymalonyl-CoA
Step 9M8
tsnAIII
+Malonyl-CoA
Step 10M9
tsnAIV
+Malonyl-CoA
Step 11M10
tsnAIV
+Methylmalonyl-CoA
Step 12M11
tsnAIV
+Methylmalonyl-CoA
Step 13M12
tsnAV
+Malonyl-CoA
Inactive: KR
Step 14
tsnC
Step 15
tsnB
Step 16
?
Step 17TE
tsn20a, ?
Step 18
tsn11
Step 19
tsn15
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1163-1tsnAILoading
Malonyl-CoA
O=C(C)O—
2163-2tsnAIM1
163-1;Malonyl-CoA
from: 163-1
OC(/C=C/C)=O—
3163-3tsnAIM2
163-2;Methylmalonyl-CoA
from: 163-2
OC([C@@H](C)C/C=C/C)=O—
4163-4tsnAIIM3
163-3;Methylmalonyl-CoA
from: 163-3
C[C@H]([C@H](O)[C@@H](C)C/C=C/C)C(O)=O{'Inactive': ['DH']}
5163-5tsnAIIM4
163-4;Malonyl-CoA
from: 163-4
OC(/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C)=O—
6163-6tsnAIIM5
163-5;Malonyl-CoA
from: 163-5
OC(C[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C)=O—
7163-7tsnAIIIM6
163-6;Methylmalonyl-CoA
from: 163-6
C[C@H](CC[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C)C(O)=O—
8163-8tsnAIIIM7
163-7;Hydroxymalonyl-CoA
from: 163-7
OC/C(C(O)=O)=C\[C@H](C)CC[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C—
9163-9tsnAIIIM8
163-8;Malonyl-CoA
from: 163-8
OC(/C=C/C(CO)=C/[C@H](C)CC[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C)=O—
10163-10tsnAIVM9
163-9;Malonyl-CoA
from: 163-9
OC(CC/C=C/C(CO)=C/[C@H](C)CC[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C)=O—
11163-11tsnAIVM10
163-10;Methylmalonyl-CoA
from: 163-10
C[C@H](CCC/C=C/C(CO)=C/[C@H](C)CC[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C)C(O)=O—
12163-12tsnAIVM11
163-11;Methylmalonyl-CoA
from: 163-11
OC(/C(C)=C/[C@@H](CCC/C=C/C(CO)=C/[C@H](C)CC[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C)C)=O—
13163-13tsnAVM12
163-12;Malonyl-CoA
from: 163-12
O=C(O)CC(/C(C)=C/[C@@H](CCC/C=C/C(CO)=C/[C@H](C)CC[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)C/C=C/C)C)C)=O{'Inactive': ['KR']}
14163-14tsnC—
163-13
from: 163-13
O=C(O)CC(/C(C)=C/[C@@H](CCC/C=C/C(CO)=C/[C@H](C)CC[C@H](O)/C=C/[C@@H]([C@H](O)[C@@H](C)CC(O1)C1C)C)C)=O—
15163-15tsnB—
163-14
from: 163-14
O=C(O)CC(/C(C)=C/[C@@H](CCC/C=C/C(CO)=C/[C@H](C)CC[C@H](O)/C=C/[C@H](C)[C@]1([H])O[C@]([C@H](C)O)([H])C[C@@H]1C)C)=O—
16163-16?—
163-15
from: 163-15
O=C(O)CC(/C(C)=C/[C@@H](CCC/C=C/C(CO)=C/[C@H](C)CC[C@H](O)/C=C/[C@H](C)[C@]1([H])O[C@]([C@H](C)OC)([H])C[C@@H]1C)C)=O—
17163-17tsn20a, ?TE
163-16
from: 163-16
C[C@H]1C[C@@]([C@H](C)OC)([H])O[C@@]1([H])[C@H](/C=C/[C@@H](O)CC[C@@H](C)/C=C(CO)/C=C/CCC[C@H](/C=C(C)/C(C2=C(O)COC2=O)=O)C)C—
18163-18tsn11—
163-17
from: 163-17
C[C@H]1C[C@@]([C@H](C)OC)([H])O[C@@]1([H])[C@H](/C=C/[C@@H](O)CC[C@@H](C)/C=C(CO)/[C@]2([H])[C@](CCC[C@H]3C)([H])[C@@]3([H])[C@H](C)[C@@](C4=C(O)COC4=O)(O)O2)C—
19163tsn15—
163-18
from: 163-18
C[C@H]1C[C@@]([C@H](C)OC)([H])O[C@@]1([H])[C@H](/C=C/[C@@H](O2)CC[C@@H](C)[C@]2([H])/C(CO)=C/[C@](CCC[C@H]3C)([H])[C@@]3([H])[C@H](C)C(C4=C(O)COC4=O)=O)C—
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