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BGC0000162PKS

Tetrocarcin A

Producing organism
Micromonospora chalcea
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
39
DOI
MIBiG entry
View on MIBiG ↗
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tetrocarcin A
C41H54N2O13782.36 Da

Gene Cluster Map45 genes · 108,236 bp

20 kb108.2 kb visible · 108,236 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
AmTAminotransferase V
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

39 steps · 40 edges
Step 1
Start
Step 17Load
ACB37740.1
+Malonyl-CoA
Step 31
Start
Step 2
ACB37734.1
Step 18M1
ACB37740.1
+Malonyl-CoA
Step 32
ACB37746.1;ACB37747.1
Step 3
ACB37735.1
Step 19M2
ACB37740.1
+Malonyl-CoA
Step 33
ACB37748.1
Step 4
ACB37754.1
Step 20M3
ACB37740.1
+Methylmalonyl-CoA
Step 5
ACB37729.1
Step 10
ACB37737.1
Step 21M4
ACB37741.1
+Malonyl-CoA
Inactive: KR
Step 6
ACB37728.1
Step 11
ACB37738.1
Step 22M5
ACB37741.1
+Methylmalonyl-CoA
Step 7
?
Step 9
ACB37756.1
Step 12
ACB37736.1
Step 23M6
ACB37741.1
+Malonyl-CoA
Step 8
ACB37756.1
Step 13
ACB37732.1
Step 24M7
ACB37741.1
+Malonyl-CoA
Step 14
ACB37731.1
Step 25M8
ACB37755.1
+Methylmalonyl-CoA
Inactive: DH
Step 15
?
Step 26M9
ACB37755.1
+Methylmalonyl-CoA
Step 16
?
Step 27M10
ACB37742.1
+Methylmalonyl-CoA
Step 28M11
ACB37743.1
+Malonyl-CoA
Inactive: KR
Step 29
?
Step 30
?
Step 34
ACB37745.1
Step 35
ACB37748.1
Step 36
?
Step 37
Spontaneous/ACB37744.1
Step 38
ACB37744.1, ACB37752.1
Step 39
ACB37723.1, ACB37730.1,…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions39 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1162-1Start—
[R][C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
2162-2ACB37734.1—
162-1
from: 162-1
[R][C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
3162-3ACB37735.1—
162-2
from: 162-2
O=C1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1C—
4162-4ACB37754.1—
162-3
from: 162-3
O=C1C(C[C@@H]([R])O[C@@H]1C)=O—
5162-5ACB37729.1—
162-4
from: 162-4
O=C1[C@H](O)C[C@@H]([R])O[C@@H]1C—
6162-6ACB37728.1—
162-5
from: 162-5
O[C@H]1C([C@H](C)O[C@H]([R])C1)=O—
7162-7?—
162-6
from: 162-6
C[C@H]1C(CC[C@@H]([R])O1)=O—
8162-8ACB37756.1—
162-7
from: 162-7
C[C@H]1[C@H](O)CC[C@@H]([R])O1—
9162-9ACB37756.1—
162-6
from: 162-6
O[C@H]1[C@@H](O)[C@H](C)O[C@H]([R])C1—
10162-10ACB37737.1—
162-4
from: 162-4
O=C1[C@H](N)C[C@@H]([R])O[C@@H]1C—
11162-11ACB37738.1—
162-10
from: 162-10
O=C1[C@@](C)(N)C[C@@H]([R])O[C@@H]1C—
12162-12ACB37736.1—
162-11
from: 162-11
O=C1[C@@](C)([N+]([O-])=O)C[C@@H]([R])O[C@@H]1C—
13162-13ACB37732.1—
162-12
from: 162-12
[R][C@@H]1C[C@](C)([N+]([O-])=O)[C@@H](N)[C@@H](C)O1—
14162-14ACB37731.1—
162-13
from: 162-13
[R][C@@H]1C[C@](C)([N+]([O-])=O)[C@@H](NC)[C@@H](C)O1—
15162-15?—
162-14
from: 162-14
[R][C@@H]1C[C@](C)([N+]([O-])=O)[C@@H](NC(O)=O)[C@@H](C)O1—
16162-16?—
162-15
from: 162-15
[R][C@@H]1C[C@](C)([N+]([O-])=O)[C@@H](NC(OC)=O)[C@@H](C)O1—
17162-17ACB37740.1Loading
Malonyl-CoA
O=C(O)C—
18162-18ACB37740.1M1
162-17;Malonyl-CoA
from: 162-17
C/C=C/C(O)=O—
19162-19ACB37740.1M2
162-18;Malonyl-CoA
from: 162-18
C/C=C/C=C/C(O)=O—
20162-20ACB37740.1M3
162-19;Methylmalonyl-CoA
from: 162-19
C/C=C/C=C/C=C(C)/C(O)=O—
21162-21ACB37741.1M4
162-20;Malonyl-CoA
from: 162-20
C/C=C/C=C/C=C(C)/C(CC(O)=O)=O{'Inactive': ['KR']}
22162-22ACB37741.1M5
162-21;Methylmalonyl-CoA
from: 162-21
C/C=C/C=C/C=C(C)/C(C/C=C(C)/C(O)=O)=O—
23162-23ACB37741.1M6
162-22;Malonyl-CoA
from: 162-22
C/C=C/C=C/C=C(C)/C(C/C=C(C)/C=C/C(O)=O)=O—
24162-24ACB37741.1M7
162-23;Malonyl-CoA
from: 162-23
C/C=C/C=C/C=C(C)/C(C/C=C(C)/C=C/C=C/C(O)=O)=O—
25162-25ACB37755.1M8
162-24;Methylmalonyl-CoA
from: 162-24
C/C=C/C=C/C=C(C)/C(C/C=C(C)/C=C/C=C/[C@@H](O)[C@H](C)C(O)=O)=O{'Inactive': ['DH']}
26162-26ACB37755.1M9
162-25;Methylmalonyl-CoA
from: 162-25
C/C=C/C=C/C=C(C)/C(C/C=C(C)/C=C/C=C/[C@@H](O)[C@H](C)CC(C)C(O)=O)=O—
27162-27ACB37742.1M10
162-26;Methylmalonyl-CoA
from: 162-26
C/C=C/C=C/C=C(C)/C(C/C=C(C)/C=C/C=C/[C@@H](O)[C@H](C)CC(C)/C=C(C)/C(O)=O)=O—
28162-28ACB37743.1M11
162-27;Malonyl-CoA
from: 162-27
C/C=C/C=C/C=C(C)/C(C/C=C(C)/C=C/C=C/[C@@H](O)[C@H](C)CC(C)/C=C(C)/C(CC(O)=O)=O)=O{'Inactive': ['KR']}
29162-29?—
162-28
from: 162-28
O=C(CC(O)=O)/C(C)=C/C(C)C[C@H](C)[C@H](O)/C=C/C=C/C(C)=C/CC(/C(C)=C/C=C/C=C/C)=O—
30162-30?—
162-29
from: 162-29
O=C([CH-]C(O)=O)[C@]([C@@H]1[C@@H](C)C[C@H](C)[C@H](O)[C@@]1([H])C=C2)(C)[C@@H]2/C(C)=C/CC(/C(C)=C/C=C/C=C/C)=O—
31162-31Start—
O[C@@H](C(OP(O)(O)=O)=O)COP(O)(O)=O—
32162-32ACB37746.1;ACB37747.1—
162-31
from: 162-31
O[C@@H](C(O)=O)CO—
33162-33ACB37748.1—
162-32
from: 162-32
O[C@@H](C([R])=O)CO—
34162-34ACB37745.1—
162-30;162-33
from: 162-30, 162-33
O=C(C(C(O)=O)C([C@@H](O)CO)O)[C@]([C@@H]1[C@@H](C)C[C@H](C)[C@H](O)[C@@]1([H])C=C2)(C)[C@@H]2/C(C)=C/CC(/C(C)=C/C=C/C=C/C)=O—
35162-35ACB37748.1—
162-34
from: 162-34
O=C(C1CC(OC1=O)CO)[C@]([C@@H]2[C@@H](C)C[C@H](C)[C@H](O)[C@@]2([H])C=C3)(C)[C@@H]3/C(C)=C/CC(/C(C)=C/C=C/C=C/C)=O—
36162-36?—
162-35
from: 162-35
O=C(C1=C(O)C(OC1=O)=C)[C@]([C@@H]2[C@@H](C)C[C@H](C)[C@H](O)[C@@]2([H])C=C3)(C)[C@@H]3/C(C)=C/CC(/C(C)=C/C=C/C=C/C)=O—
37162-37Spontaneous/ACB37744.1—
162-36
from: 162-36
O=C(C1=C2O)[C@]([C@@H]3[C@@H](C)C[C@H](C)[C@H](O)[C@@]3([H])C=C4)(C)[C@@H]4/C(C)=C/CC(/C(C)=C/C5[C@@]2(OC1=O)C[C@@H](C)C=C5)=O—
38162-38ACB37744.1, ACB37752.1—
162-37
from: 162-37
O=C(C1=C2O)[C@]([C@@H]3[C@@H](C)C[C@H](C)[C@H](O)[C@@]3([H])C=C4)(C)[C@@H]4/C(C)=C/C[C@H](O)/C(C)=C/C5[C@@]2(OC1=O)CC(C=O)=C[C@@H]5O—
39162ACB37723.1, ACB37730.1, ACB37750.1, ACB37751.1, ACB37733.1—
162-8;162-8;162-9;162-9;162-16;162-38
from: 162-8, 162-8, 162-9, 162-9, 162-16, 162-38
O=C(C1=C2O)[C@]([C@]3([H])[C@@H](C)C[C@H](C)[C@H](O[C@H]4C[C@@H](O[C@@H]5O[C@@H](C)[C@H](O[C@@H]6C[C@@H](O)[C@@H](O[C@H]7CC[C@@H](O)[C@H](C)O7)[C@H](C)O6)CC5)[C@@H](OC(C)=O)[C@H](C)O4)[C@@]3([H])C=C8)(C)[C@@H]8/C(C)=C/C[C@H](O[C@H]9C[C@](C)([N+]([O-])=O)[C@@H](NC(C)=O)[C@@H](C)O9)/C(C)=C/[C@H]%10[C@@]2(OC1=O)CC(C=O)=C[C@@H]%10O—
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