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BGC0000159PKS

Tautomycetin

Producing organism
Streptomyces spiroverticillatus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
22
DOI
MIBiG entry
View on MIBiG ↗
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tautomycin
C41H66O13766.45 Da

Gene Cluster Map29 genes · 94,050 bp

20 kb94.0 kb visible · 94,050 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
FkFkbH-like
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

22 steps · 20 edges
Step Load
ttmJ
+Isobutyryl-CoA
Step 1
Start
Step 2
Start
+2-Oxoglutarate
Step
ttmO
Step M1
ttmJ
+Methoxymalonyl-ACP
Step
ttmP
Step M2
ttmJ, ttmK?
+(159-8, Malonyl-CoA)
Step
ttmR
Step M3
ttmJ, ttmK?
+(159-9, Methylmalonyl-CoA)
Step
ttmM
Step M4
ttmJ, ttmK?
+(159-10, Malonyl-CoA)
Step M5
ttmJ, ttmK?
+(159-11, Methylmalonyl-CoA)
Step M6
ttmJ, ttmK?
+(159-12, Methylmalonyl-CoA)
Step M7
ttmI, ttmK?
+(159-13, Malonyl-CoA)
Step M8
ttmI, ttmK?
+(159-14, Malonyl-CoA)
Step M9
ttmI, ttmK?
+(159-15, Methylmalonyl-CoA)
Step M10
ttmH, ttmK?
+(159-16, Malonyl-CoA)
Step M11
ttmH, ttmK?
+(159-17, Methylmalonyl-CoA)
Step M12
ttmH, ttmK?
+(159-18, Malonyl-CoA)
Step TE
ttmH
Step
ttmG
Step
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1159-1Start—
O=C([R])C(C([O-])=O)C—
2159-2Start—
2-Oxoglutarate
O=C(O)C(CCC(O)=O)=O—
159-3ttmO—
159-1;159-2
from: 159-1, 159-2
O=C([O-])C(C([H])(C)C([R])=O)(O)CCC(O)=O—
159-4ttmP—
159-3
from: 159-3
O=C(C1([H])C)OC(C(O)1CCC(O)=O)=O—
159-5ttmR—
159-4
from: 159-4
O=C(C(C)=C1CCC(O)=O)OC1=O—
159-6ttmM—
159-5
from: 159-5
O=C(C(C)=C1[C@H](O)CC(O)=O)OC1=O—
159-7ttmJLoading
Isobutyryl-CoA
CC(C)C(O)=O—
159-8ttmJM1
159-7;Methoxymalonyl-ACP
from: 159-7
OC(C(C(C(C)C)O)OC)=O—
159-9ttmJ, ttmK?M2
(159-8;Malonyl-CoA);159-6?
from: 159-6?
OC(CC(O)=O)C(C(C(C)C)O[R])OC—
159-10ttmJ, ttmK?M3
(159-9;Methylmalonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)=O)=O)C(C(C(C)C)O[R])OC—
159-11ttmJ, ttmK?M4
(159-10;Malonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CC(O)=O)=O)C(C(C(C)C)O[R])OC—
159-12ttmJ, ttmK?M5
(159-11;Methylmalonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CCC(C)C(O)=O)=O)C(C(C(C)C)O[R])OC—
159-13ttmJ, ttmK?M6
(159-12;Methylmalonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CCC(C)C(O)C(C)C(O)=O)=O)C(C(C(C)C)O[R])OC—
159-14ttmI, ttmK?M7
(159-13;Malonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CCC(C)C(O)C(C)CCC(O)=O)=O)C(C(C(C)C)O[R])OC—
159-15ttmI, ttmK?M8
(159-14;Malonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CCC(C)C(O)C(C)CCC(CC(O)=O)=O)=O)C(C(C(C)C)O[R])OC—
159-16ttmI, ttmK?M9
(159-15;Methylmalonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CCC(C)C(O)C(C)CCC(CCC(C)C(O)=O)=O)=O)C(C(C(C)C)O[R])OC—
159-17ttmH, ttmK?M10
(159-16;Malonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CCC(C)C(O)C(C)CCC(CCC(C)C(O)CC(O)=O)=O)=O)C(C(C(C)C)O[R])OC—
159-18ttmH, ttmK?M11
(159-17;Methylmalonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CCC(C)C(O)C(C)CCC(CCC(C)C(O)CCC(C)C(O)=O)=O)=O)C(C(C(C)C)O[R])OC—
159-19ttmH, ttmK?M12
(159-18;Malonyl-CoA);159-6?
from: 159-6?
OC(CC(C(C)C(O)CCC(C)C(O)C(C)CCC(CCC(C)C(O)CCC(C)C(CC(O)=O)=O)=O)=O)C(C(C(C)C)O[R])OC—
159-20ttmHTE
159-19
from: 159-19
O[C@H](CC([C@@H](C)[C@@H](O)CC[C@@H](C)[C@H](O)[C@@H](C)CCC(CC[C@@H](C)[C@@H](O)CC[C@H](C)C(CC(O)=O)=O)=O)=O)[C@@H]([C@@H](C(C)C)OC(C[C@H](C1=C(C)C(OC1=O)=O)O)=O)OC—
159-21ttmG—
159-20
from: 159-20
O[C@H](CC([C@@H](C)[C@@H](O)CC[C@@H](C)[C@H](O)[C@@H](C)CCC(CC[C@@H](C)[C@@H](O)CC[C@H](C)C(C)=O)=O)=O)[C@@H]([C@@H](C(C)C)OC(C[C@H](C1=C(C)C(OC1=O)=O)O)=O)OC—
159?—
159-21
from: 159-21
O=C(OC1=O)C([C@@H](CC(O[C@@H]([C@@H](OC)[C@@H](CC([C@H]([C@H](CC[C@H]([C@]2([H])O[C@]3(CC[C@@H](C)[C@@](CC[C@@H](C(C)=O)C)([H])O3)CC[C@@H]2C)C)O)C)=O)O)C(C)C)=O)O)=C1C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture