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BGC0000158PKS

Tautomycetin

Producing organism
Streptomyces griseochromogenes
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
19
DOI
MIBiG entry
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tautomycetin
C33H50O10606.34 Da

Gene Cluster Map21 genes · 78,527 bp

KSKSKSKSKSKSKSKSKSKS20 kb78.5 kb visible · 78,527 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1
Start
Step 2
Start
+2-Oxoglutarate
Step 7Load
ttnA
+Malonyl-CoA
Step 3
ttnO
Step 8M1
ttnA
+Methylmalonyl-CoA
Inactive: DH
Step 4
ttnP
Step 9M2
ttnA
+Malonyl-CoA
Step 5
ttnR
Step 10M3
ttnA
+Methylmalonyl-CoA
Inactive: ER, DH
Step 6
ttnM
Step 11M4
ttnA
+Malonyl-CoA
Inactive: DH
Step 12M5
ttnA
+Methylmalonyl-CoA
Step 13M6
ttnB;ttnK
+Methylmalonyl-CoA
Step 14M7
ttnB
+Malonyl-CoA
Step 15M8
ttnB
+Ethylmalonyl-CoA
Step 16M9
ttnB
+Malonyl-CoA
Step 17TE
ttnB
Step 18
ttnI
Step 19
ttnC, ttnD, ttnF
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1158-1Start—
O=C([R])C(C([O-])=O)C—
2158-2Start—
2-Oxoglutarate
O=C(O)C(CCC(O)=O)=O—
3158-3ttnO—
158-1;158-2
from: 158-1, 158-2
O=C([O-])C(C([H])(C)C([R])=O)(O)CCC(O)=O—
4158-4ttnP—
158-3
from: 158-3
O=C(C1([H])C)OC(C(O)1CCC(O)=O)=O—
5158-5ttnR—
158-4
from: 158-4
O=C(C(C)=C1CCC(O)=O)OC1=O—
6158-6ttnM—
158-5
from: 158-5
O=C(C(C)=C1[C@H](O)CC(O)=O)OC1=O—
7158-7ttnALoading
Malonyl-CoA
O=C(C)O—
8158-8ttnAM1
158-7;Methylmalonyl-CoA
from: 158-7
O[C@H](C)[C@H](C(O)=O)C{'Inactive': ['DH']}
9158-9ttnAM2
158-8;Malonyl-CoA
from: 158-8
O[C@H](C)[C@H]([C@H](O)CC(O)=O)C—
10158-10ttnAM3
158-9;Methylmalonyl-CoA
from: 158-9
O[C@H](C)[C@H]([C@H](O)CC([C@H](C(O)=O)C)=O)C{'Inactive': ['ER', 'DH']}
11158-11ttnAM4
158-10;Malonyl-CoA
from: 158-10
O[C@H](C)[C@H]([C@H](O)CC([C@H]([C@@H](O)CC(O)=O)C)=O)C{'Inactive': ['DH']}
12158-12ttnAM5
158-11;Methylmalonyl-CoA
from: 158-11
O[C@H](C)[C@H]([C@H](O)CC([C@H]([C@@H](O)CC[C@@H](C(O)=O)C)C)=O)C—
13158-13ttnB;ttnKM6
158-6;158-12;Methylmalonyl-CoA
from: 158-6, 158-12
C[C@@H](OC(C[C@H](C1=C(C(OC1=O)=O)C)O)=O)[C@H]([C@H](O)CC([C@H]([C@@H](O)CC[C@@H](C[C@H](C(O)=O)C)C)C)=O)C—
14158-14ttnBM7
158-13;Malonyl-CoA
from: 158-13
C[C@@H](OC(C[C@H](C1=C(C(OC1=O)=O)C)O)=O)[C@H]([C@H](O)CC([C@H]([C@@H](O)CC[C@@H](C[C@H](CCC(O)=O)C)C)C)=O)C—
15158-15ttnBM8
158-14;Ethylmalonyl-CoA
from: 158-14
C[C@@H](OC(C[C@H](C1=C(C(OC1=O)=O)C)O)=O)[C@H]([C@H](O)CC([C@H]([C@@H](O)CC[C@@H](C[C@H](CC/C=C(C(O)=O)\CC)C)C)C)=O)C—
16158-16ttnBM9
158-15;Malonyl-CoA
from: 158-15
C[C@@H](OC(C[C@H](C1=C(C(OC1=O)=O)C)O)=O)[C@H]([C@H](O)CC([C@H]([C@@H](O)CC[C@@H](C[C@H](CC/C=C([C@H](O)CC(O)=O)\CC)C)C)C)=O)C—
17158-17ttnBTE
158-16
from: 158-16
C[C@H](C[C@H](CC[C@@H]([C@@H](C(C[C@H]([C@@H]([C@H](OC(C[C@@H](O)C(C(O1)=O)=C(C)C1=O)=O)C)C)O)=O)C)O)C)CC/C=C(CC)/[C@H](CC(O)=O)O—
18158-18ttnI—
158-17
from: 158-17
C[C@H](C[C@H](CC[C@@H]([C@@H](C(C[C@H]([C@@H]([C@H](OC(C[C@@H](O)C(C(O1)=O)=C(C)C1=O)=O)C)C)O)=O)C)O)C)CC(/C=C(CC)/[C@H](CC(O)=O)O)=O—
19158ttnC, ttnD, ttnF—
158-18
from: 158-18
C[C@H](C[C@H](CC[C@@H]([C@@H](C(C[C@H]([C@@H]([C@H](OC(C[C@@H](O)C(C(O1)=O)=C(C)C1=O)=O)C)C)O)=O)C)O)C)CC(/C=C(CC)/C=C)=O—
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