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BGC0000157PKS

Tautomycetin

Producing organism
Streptomyces sp. CK4412
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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tautomycetin
C33H50O10606.34 Da

Gene Cluster Map14 genes · 70,100 bp

KSKSKSKSKSKSKSKSKSKSER10 kb70.1 kb visible · 70,100 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1M1
ABI94379.1
+Malonyl-CoA
Step 13
Start
+2-Oxoglutarate
Step 14
Start
+Propinate
Step 2M2
ABI94379.1
+Methylmalonyl-CoA
Inactive: ER
Step 15
?
Step 3M3
ABI94379.1
+Malonyl-CoA
Step 4M4
ABI94379.1
+Methylmalonyl-CoA
Inactive: ER
Step 5M5
ABI94379.1
+Malonyl-CoA
Inactive: ER
Step 6M6
ABI94379.1
+Methylmalonyl-CoA
Step 7M7
ABI94380.1
+Methylmalonyl-CoA
Step 8M8
ABI94380.1
+Malonyl-CoA
Step 9M9
ABI94380.1
+Ethylmalonyl-CoA
Step 10M10
ABI94380.1
+Malonyl-CoA
Step 11TE
ABI94380.1
Step 12
?
Step 16
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1157-1ABI94379.1M1
Malonyl-CoA
O=C(C)O—
2157-2ABI94379.1M2
157-1;Methylmalonyl-CoA
from: 157-1
OC(C)C(C(O)=O)C{'Inactive': ['ER']}
3157-3ABI94379.1M3
157-2;Malonyl-CoA
from: 157-2
OC(C)C(C(O)CC(O)=O)C—
4157-4ABI94379.1M4
157-3;Methylmalonyl-CoA
from: 157-3
OC(C)C(C(O)CC(C(C(O)=O)C)=O)C{'Inactive': ['ER']}
5157-5ABI94379.1M5
157-4;Malonyl-CoA
from: 157-4
OC(C)C(C(O)CC(C(C(O)CC(O)=O)C)=O)C{'Inactive': ['ER']}
6157-6ABI94379.1M6
157-5;Methylmalonyl-CoA
from: 157-5
OC(C)C(C(O)CC(C(C(O)CCC(C(O)=O)C)C)=O)C—
7157-7ABI94380.1M7
157-6;Methylmalonyl-CoA
from: 157-6
OC(C)C(C(O)CC(C(C(O)CCC(CC(C(O)=O)C)C)C)=O)C—
8157-8ABI94380.1M8
157-7;Malonyl-CoA
from: 157-7
OC(C)C(C(O)CC(C(C(O)CCC(CC(CCC(O)=O)C)C)C)=O)C—
9157-9ABI94380.1M9
157-8;Ethylmalonyl-CoA
from: 157-8
OC(C)C(C(O)CC(C(C(O)CCC(CC(CC/C=C(C(O)=O)\CC)C)C)C)=O)C—
10157-10ABI94380.1M10
157-9;Malonyl-CoA
from: 157-9
OC(C)C(C(O)CC(C(C(O)CCC(CC(CC/C=C(C(O)CC(O)=O)\CC)C)C)C)=O)C—
11157-11ABI94380.1TE
157-10
from: 157-10
O=C(O)CC(/C(CC)=C/CCC(CC(CCC(C(C(CC(C(C(O)C)C)O)=O)C)O)C)C)O—
12157-12?—
157-11
from: 157-11
CC(CC(CCC(C(C(CC(C(C(O)C)C)O)=O)C)O)C)CC(/C=C(CC)/C=C)=O—
13157-13Start—
2-Oxoglutarate
O=C(CCC(C(O)=O)=O)O—
14157-14Start—
Propinate
O=C(O)C—
15157-15?—
157-13;157-14
from: 157-13, 157-14
O=C1OC(C(C)=C1C(CC(O)=O)O)=O—
16157?—
157-12;157-15
from: 157-12, 157-15
C=C/C(CC)=C/C(C[C@@H](C[C@H](CC[C@@H]([C@@H](C(C[C@H]([C@@H]([C@H](OC(CC(O)C(C(O1)=O)=C(C)C1=O)=O)C)C)O)=O)C)O)C)C)=O—
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