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BGC0000150Hybrid

Sporolide A;Sporolide B

Producing organism
Salinispora tropica CNB-440
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Salinispora
Biosynthetic class
NRPS (Type I);PKS (Enediyne type I)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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C24H23ClO12538.09 Da

Gene Cluster Map47 genes · 59,694 bp

KSCA10 kb59.7 kb visible · 59,694 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1
Start
+L-Tyrosine
Step 11
Strop_2697, Strop_2694,…
+Acetyl-CoA, Malonyl-CoA
Step 2
?
Step 12
Strop_2711
Step 3
Strop_2727
Step 4
Strop_2725
Step 5
Strop_2713
Step 6
Strop_2731
Step 7
Strop_2723
Step 8
Strop_2733
Step 9
Strop_2728
Step 10
Strop_2724, Strop_2702
Step 13
Strop_2721
Step 14
?
Step 15
?
Step 16
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1150-1Start—
L-Tyrosine
OC(C(N)CC1=CC=C(O)C=C1)=O—
2150-2?—
150-1
from: 150-1
OC(C(CC1=CC=C(O)C=C1)=O)=O—
3150-3Strop_2727—
150-2
from: 150-2
O=C([O-])[C@@H](O)C1=CC=C(O)C=C1—
4150-4Strop_2725—
150-3
from: 150-3
O=C(O)[C@@H](O)C1=CC=C(O)C=C1—
5150-5Strop_2713—
150-4
from: 150-4
O=C(O)[C@@H](O)C1=CC=C(O)C(O)=C1—
6150-6Strop_2731—
150-5
from: 150-5
O=C(O)[C@@H](O)C1=C(O)C=C(O)C(O)=C1—
7150-7Strop_2723—
150-6
from: 150-6
O=C(O)[C@@H](O)C1=CC(C(O)=CC1=O)=O—
8150-8Strop_2733—
150-7
from: 150-7
O=C(O)[C@@H](O)C1=CC(C(O)=C(C)C1=O)=O—
9150-9Strop_2728—
150-8
from: 150-8
O=C(O)[C@@H](OC)C1=CC(C(O)=C(C)C1=O)=O—
10150-10Strop_2724, Strop_2702—
150-9
from: 150-9
O=C(O)[C@H](OC)[C@]1([C@@H](O1)C(C(O)=C2C)=O)C2=O—
11150-11Strop_2697, Strop_2694, Strop_2695, Strop_2696, Strop_2698, Strop_2699, Strop_2700, Strop_2701, Strop_2704, Strop_2705, Strop_2706—
Acetyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
C1(/C2=C/C#C[C@@H](O3)[C@]43C=C[C@H]5[C@@]4(O5)CC#C2)CO1—
12150-12Strop_2711—
150-11
from: 150-11
O[C@@H](CO)/C1=C/C#C[C@@H](O2)[C@]32[C@H](O)C[C@H]4[C@@]3(O4)CC#C1—
13150-13Strop_2721—
150-10;150-12
from: 150-10, 150-12
O[C@@H](COC([C@H](OC)[C@]1(O2)[C@@H]2C(C(O)=C(C)C1=O)=O)=O)/C3=C/C#C[C@@H](O4)[C@]54[C@H](O)C[C@H]6[C@@]5(O6)CC#C3—
14150-14?—
150-13
from: 150-13
O[C@@H](COC([C@H](OC)[C@]1(O2)[C@@H]2[C@@]3(O)C(O4)=C(C)C1=O)=O)/C5=C/C#CCC64[C@H](O)CC(O)[C@@]6(O3)CC#C5—
15150(1)?—
150-14
from: 150-14
O[C@H]1C2(OC3=C(C)C([C@]([C@@H]4[C@@]35O)(O4)[C@@H](OC)C(OC[C@H](O)C(C(Cl)=C67)=CC([H])=C7[C@H]2O)=O)=O)[C@@]6(O5)C(O)C1—
16150(2)?—
150-14
from: 150-14
O[C@H]1C2(OC3=C(C)C([C@]([C@@H]4[C@@]35O)(O4)[C@@H](OC)C(OC[C@H](O)C(C([H])=C67)=CC(Cl)=C7[C@H]2O)=O)=O)[C@@]6(O5)C(O)C1—
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