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BGC0000144PKS

Salinomycin

Producing organism
Streptomyces albus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗
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salinomycin
C42H70O11750.49 Da

Gene Cluster Map49 genes · 127,961 bp

20 kb128.0 kb visible · 127,961 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase
CALCoA-ligase (CAL)
AmTAminotransferase III

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1Load
slnA1
+Malonyl-CoA
Step 2M1
slnA1
+Ethylmalonyl-CoA
Step 3M2
slnA1
+Malonyl-CoA
Step 4M3
slnA2
+Methylmalonyl-CoA
Step 5M4
slnA2
+Malonyl-CoA
Step 6M5
slnA3
+Malonyl-CoA
Step 7M6
slnA3
+Malonyl-CoA
Step 8M7
slnA4
+Methylmalonyl-CoA
Inactive: KR
Step 9M8
slnA5
+Methylmalonyl-CoA
Step 10M9
slnA5
+Ethylmalonyl-CoA
Step 11M10
slnA6
+Methylmalonyl-CoA
Inactive: DH
Step 12M11
slnA7
+Methylmalonyl-CoA
Step 13M12
slnA8
+Methylmalonyl-CoA
Step 14M13
slnA8
+Malonyl-CoA
Step 15M14
slnA9
+Ethylmalonyl-CoA
Step 16
?
Step 17
?
Step 18
slnC
Step 19
slnBI, slnBII
Step 20
slnE, slnF
Step 21
slnBI?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1144-1slnA1Loading
Malonyl-CoA
O=C(O)C—
2144-2slnA1M1
144-1;Ethylmalonyl-CoA
from: 144-1
C/C=C(CC)/C(O)=O—
3144-3slnA1M2
144-2;Malonyl-CoA
from: 144-2
C/C=C(CC)/CCC(O)=O—
4144-4slnA2M3
144-3;Methylmalonyl-CoA
from: 144-3
C/C=C(CC)/CC/C=C(C(O)=O)\C—
5144-5slnA2M4
144-4;Malonyl-CoA
from: 144-4
C/C=C(CC)/CC/C=C(CCC(O)=O)\C—
6144-6slnA3M5
144-5;Malonyl-CoA
from: 144-5
C/C=C(CC)/CC/C=C(CCC(CC(O)=O)=O)\C—
7144-7slnA3M6
144-6;Malonyl-CoA
from: 144-6
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(O)=O)=O)\C—
8144-8slnA4M7
144-7;Methylmalonyl-CoA
from: 144-7
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(C(C(O)=O)C)=O)=O)\C{'Inactive': ['KR']}
9144-9slnA5M8
144-8;Methylmalonyl-CoA
from: 144-8
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(C(CC(C(O)=O)C)C)=O)=O)\C—
10144-10slnA5M9
144-9;Ethylmalonyl-CoA
from: 144-9
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(C(CC(C(O)C(C(O)=O)CC)C)C)=O)=O)\C—
11144-11slnA6M10
144-10;Methylmalonyl-CoA
from: 144-10
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(C(CC(C(O)C(C(C(C)C(O)=O)=O)CC)C)C)=O)=O)\C{'Inactive': ['DH']}
12144-12slnA7M11
144-11;Methylmalonyl-CoA
from: 144-11
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(C(CC(C(O)C(C(C(C)C(O)C(C)C(O)=O)=O)CC)C)C)=O)=O)\C—
13144-13slnA8M12
144-12;Methylmalonyl-CoA
from: 144-12
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(C(CC(C(O)C(C(C(C)C(O)C(C)C(O)C(C)C(O)=O)=O)CC)C)C)=O)=O)\C—
14144-14slnA8M13
144-13;Malonyl-CoA
from: 144-13
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(C(CC(C(O)C(C(C(C)C(O)C(C)C(O)C(C)CCC(O)=O)=O)CC)C)C)=O)=O)\C—
15144-15slnA9M14
144-14;Ethylmalonyl-CoA
from: 144-14
C/C=C(CC)/CC/C=C(CCC(CC(O)CC(C(CC(C(O)C(C(C(C)C(O)C(C)C(O)C(C)CCC(O)C(CC)C(O)=O)=O)CC)C)C)=O)=O)\C—
16144-16?—
144-15
from: 144-15
O=C(O)[C@H](CC)C(O)CC[C@H](C)C([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)C([C@@H](C)C[C@@H](C)C(CC(CC(CC/C(C)=C\CC/C(CC)=C/C)=O)O)=O)O)=O)O—
17144-17?—
144-16
from: 144-16
O=C(O)/C(CC)=C\CC[C@H](C)C([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)C([C@@H](C)C[C@@H](C)C(/C=C\CC(CC/C(C)=C\CC/C(CC)=C/C)=O)=O)O)=O)O—
18144-18slnC—
144-17
from: 144-17
O=C(O)/C(CC)=C\CC[C@H](C)C([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)C([C@@H](C)C[C@@H](C)C(/C=C\CC(CC[C@@]([C@H]1CC[C@@]2([C@H](O2)C)CC)(O1)C)=O)=O)O)=O)O—
19144-19slnBI, slnBII—
144-18
from: 144-18
O=C(O)[C@H](CC)[C@]1([H])CC[C@H](C)[C@@]([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)[C@@]2([H])OC(C=CC[C@@]34CC[C@](O3)([C@](O5)([H])CC[C@](O)(CC)[C@@H]5C)C)(O4)[C@H](C)C[C@@H]2C)=O)([H])O1—
20144-20slnE, slnF—
144-19
from: 144-19
O=C(O)[C@H](CC)[C@]1([H])CC[C@H](C)[C@@]([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)[C@@]2([H])OC(C=C[C@@H](O)[C@@]34CC[C@](O3)([C@](O5)([H])CC[C@](O)(CC)[C@@H]5C)C)(O4)[C@H](C)C[C@@H]2C)=O)([H])O1—
21144slnBI?—
144-20
from: 144-20
O=C(O)[C@H](CC)[C@]1([H])CC[C@H](C)[C@@]([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)[C@@]2([H])OC(C=C[C@@H](O)[C@@]34CC[C@](O3)([C@](O5)([H])CC[C@](O)(CC)[C@@H]5C)C)(O4)[C@H](C)C[C@@H]2C)=O)([H])O1—
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