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BGC0000142PKS

Salinilactam

Producing organism
Salinispora tropica CNB-440
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Salinispora
Biosynthetic class
PKS (Unknown)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
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salinilactam
C28H39NO5469.28 Da

Gene Cluster Map25 genes · 81,989 bp

KSKSKSKSAAKSKSKSKSKSKSKS20 kb82.0 kb visible · 81,989 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1Load
Strop_2768
Step 2M1
Strop_2768
+Malonyl-CoA
Step 3M2
Strop_2768
+Malonyl-CoA
Step 4M3
Strop_2768
+Malonyl-CoA
Step 5M4
Strop_2781
+Malonyl-CoA
Step 6M5
Strop_2781
+Malonyl-CoA
Step 7M6
Strop_2780
+Malonyl-CoA
Step 8M7
Strop_2780
+Hydroxymalonyl-CoA
Step 9M8
Strop_2779
+Malonyl-CoA
Step 10M9
Strop_2778
+Malonyl-CoA
Step 11M10
Strop_2778
+Malonyl-CoA
Step 12TE
Strop_2778
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1142-1Strop_2768Loading
NC(C)C/C=C/C(O)=O—
2142-2Strop_2768M1
142-1;Malonyl-CoA
from: 142-1
NC(C)C/C=C/C=C/C(O)=O—
3142-3Strop_2768M2
142-2;Malonyl-CoA
from: 142-2
C/C(C(O)=O)=C\C=C\C=C\CC(C)N—
4142-4Strop_2768M3
142-3;Malonyl-CoA
from: 142-3
CC(/C=C/C(O)=O)=C\C=C\C=C\CC(C)N—
5142-5Strop_2781M4
142-4;Malonyl-CoA
from: 142-4
CC(/C=C/C=C/C(O)=O)=C\C=C\C=C\CC(C)N—
6142-6Strop_2781M5
142-5;Malonyl-CoA
from: 142-5
OC(/C=C/C=C/C=C/C(C)=C/C=C/C=C/CC(C)N)=O—
7142-7Strop_2780M6
142-6;Malonyl-CoA
from: 142-6
OC(C[C@H](/C=C/C=C/C=C/C(C)=C/C=C/C=C/CC(C)N)O)=O—
8142-8Strop_2780M7
142-7;Hydroxymalonyl-CoA
from: 142-7
OC(C([C@H](C[C@H](/C=C/C=C/C=C/C(C)=C/C=C/C=C/CC(C)N)O)O)O)=O—
9142-9Strop_2779M8
142-8;Malonyl-CoA
from: 142-8
CC([C@H](C([C@H](C[C@H](/C=C/C=C/C=C/C(C)=C/C=C/C=C/CC(C)N)O)O)O)O)C(O)=O—
10142-10Strop_2778M9
142-9;Malonyl-CoA
from: 142-9
CC([C@H](C([C@H](C[C@H](/C=C/C=C/C=C/C(C)=C/C=C/C=C/CC(C)N)O)O)O)O)/C=C/C(O)=O—
11142-11Strop_2778M10
142-10;Malonyl-CoA
from: 142-10
O=C(O)/C=C/C=C/C([C@H](C([C@H](C[C@H](/C=C/C=C/C=C/C(C)=C/C=C/C=C/CC(C)N)O)O)O)O)C—
12142Strop_2778TE
142-11
from: 142-11
O=C(NC(C)C/C=C/C=C/C=C(C)/C=C/C=C/C=C/[C@H](O)C[C@H](O)C(O)[C@@H]1O)/C=C/C=C/C1C—
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