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BGC0000141PKS

Rubradirin

Producing organism
Streptomyces rubradiris
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
PKS (Unknown)
Total steps
36
DOI
MIBiG entry
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rubradirin
C48H46N4O20998.27 Da

Gene Cluster Map58 genes · 105,657 bp

20 kb105.7 kb visible · 105,657 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

36 steps · 35 edges
Step 1
Start
+UDP-glucose
Step 19
Start
+Glucose-1-phospha…
Step 30
Start
+L-Tyrosine
Step 35
?
+Aspartic semiadeh…, Pyruvate
Step 2
rubL
Step 20
rubN1
Step 31
rubC1
Step 3
rubK
Step 21
rubN2
Step 32
rubC2
Step 4
rubM
Step 22
rubN3
Step 33
rubC3
Step 5
rubN
Step 23
rubN4
Step 34
?
Step 6
?
Step 24
rubN6
Step 7
?
Step 25
rubN5
Step 8
rubH
Step 26
rubN7
Step 9
rubG, rubJ, rubK
Step 27
rubN8
Step 10Load
rubA
Step 28
?
Step 11M1
rubA
+Methylmalonyl-CoA
Inactive: DH
Step 29
?
Step 12M2
rubA
+Malonyl-CoA
Step 13M3
rubA
+Methylmalonyl-CoA
Inactive: KR
Step 14M4
rubB
+Methylmalonyl-CoA
Step 15M5
rubB
+Methylmalonyl-CoA
Inactive: DH
Step 16M6
rubB
+Methylmalonyl-CoA
Inactive: DH, KR
Step 17
rubF
Step 18
?
Step 36
rubG1, rubG2, rubC1, ?
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions36 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1141-1Start
UDP-glucose
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO
2141-2rubL
141-1
from: 141-1
O[C@H]1C([C@@H](O)[C@@H]([R])O[C@@H]1CO)=O
3141-3rubK
141-2
from: 141-2
O[C@H]1[C@H](N)[C@@H](O)[C@@H]([R])O[C@@H]1CO
4141-4rubM
141-3
from: 141-3
O[C@H]1[C@H](N)[C@@H](O)[C@@H](O)O[C@@H]1COP(O)(O)=O
5141-5rubN
141-4
from: 141-4
O[C@H]1[C@H](N)[C@@H](O)[C@@H](O)O[C@@H]1COO[C@H]1[C@H](N)[C@@H](O)[C@@H](O)O[C@@H]1COP(O)(O)=O
6141-6?
141-5
from: 141-5
N[C@H]1[C@H](O)[C@H](O[C@@]1(CO)O)COP(O)(O)=O
7141-7?
141-6
from: 141-6
[H][C@@](O)([C@](O)(COP(O)(O)=O)[H])C=N
8141-8rubH
141-7
from: 141-7
[H][C@@](O)([C@](O)(COP(O)(O)=O)[H])[C@@]([H])(C([H])(C(C(O)=O)=O)[H])N
9141-9rubG, rubJ, rubK
141-8
from: 141-8
OC1=CC(N)=CC(C(O)=O)=C1
10141-10rubALoading
141-9
from: 141-9
OC1=CC(N)=CC(C(O)=O)=C1
11141-11rubAM1
141-10;Methylmalonyl-CoA
from: 141-10
OC1=CC(N)=CC(C(O)C(C)C(O)=O)=C1{'Inactive': ['DH']}
12141-12rubAM2
141-11;Malonyl-CoA
from: 141-11
OC1=CC(N)=CC(C(O)C(C)C(CC(O)=O)=O)=C1
13141-13rubAM3
141-12;Methylmalonyl-CoA
from: 141-12
OC1=CC(N)=CC(C(O)C(C)C(CC(C(C)C(O)=O)=O)=O)=C1{'Inactive': ['KR']}
14141-14rubBM4
141-13;Methylmalonyl-CoA
from: 141-13
CC(C(O)=O)/C=C(C)/C(C1=C(O)C(C)=C(O)C(C(C(N)=C2)=O)=C1C2=O)=O
15141-15rubBM5
141-14;Methylmalonyl-CoA
from: 141-14
CC([C@@H](O)CC(O)=O)/C=C(C)/C(C1=C(O)C(C)=C(O)C(C(C(N)=C2)=O)=C1C2=O)=O{'Inactive': ['DH']}
16141-16rubBM6
141-15;Methylmalonyl-CoA
from: 141-15
CC([C@@H](O)CC(C(C)C(O)=O)=O)/C=C(C)/C(C1=C(O)C(C)=C(O)C(C(C(N)=C2)=O)=C1C2=O)=O{'Inactive': ['DH', 'KR']}
17141-17rubF
141-16
from: 141-16
CC1=CC2=C(C(C=C(NC(C(C(C3)=O)C)=O)C2=O)=O)C(C(C(C)=CC(C3O)C)=O)=C1O
18141-18?
141-17
from: 141-17
CC1=CC2=C(C(C=C(NC(C(C(C3O)=O)C)=O)C2=O)=O)C(C(C(C)=CC(C3O)C)=O)=C1O
19141-19Start
Glucose-1-phosphate
OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@@H]1O
20141-20rubN1
141-19
from: 141-19
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O
21141-21rubN2
141-20
from: 141-20
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1=O
22141-22rubN3
141-21
from: 141-21
C[C@H]1O[C@H]([R])CC(C1=O)=O
23141-23rubN4
141-22
from: 141-22
C[C@H]1O[C@H]([R])C[C@H](N)C1=O
24141-24rubN6
141-23
from: 141-23
C[C@H]1O[C@H]([R])C[C@H](N)[C@@H]1O
25141-25rubN5
141-24
from: 141-24
C[C@H]1O[C@H]([R])C[C@@](N)(C)[C@@H]1O
26141-26rubN7
141-25
from: 141-25
C[C@H]1O[C@H]([R])C[C@@](N)(C)[C@@H]1OC
27141-27rubN8
141-26
from: 141-26
C[C@H]1O[C@H]([R])C[C@@](NO)(C)[C@@H]1OC
28141-28?
141-27/141-29
from: 141-27/141-29
C[C@H]1O[C@H]([R])C[C@@](N=O)(C)[C@@H]1OC
29141-29?
141-27/141-28
from: 141-27/141-28
C[C@H]1O[C@H]([R])C[C@](C)([N+]([O-])=O)[C@@H]1OC
30141-30Start
L-Tyrosine
N[C@H](CC1=CC=C(O)C=C1)C(O)=O
31141-31rubC1
141-30
from: 141-30
N[C@H](CC1=CC=C(O)C=C1)C(O)=O
32141-32rubC2
141-31
from: 141-31
N[C@H]([C@@H](O)C1=CC=C(O)C=C1)C(O)=O
33141-33rubC3
141-32
from: 141-32
N[C@H](C(C1=CC=C(O)C=C1)=O)C(O)=O
34141-34?
141-33
from: 141-33
NC(C(O1)=O)=C(O)C2=C1C=C(O)C=C2
35141-35?
Aspartic semiadehyde;Pyruvate
OC(C1=NC(C(O)=O)=CC(O)=C1O)=O
36141rubG1, rubG2, rubC1, ?
141-18;141-29;141-34;141-35
from: 141-18, 141-29, 141-34, 141-35
CC1=CC2=C(C(C=C(NC(C(C(C3O)=O)C)=O)C2=O)=O)C(C(C(C)=CC(C3OC(C4=NC(C(NC5=C(C(C=CC(O)=C6)=C6OC5=O)O)=O)=CC(O[C@H]7C[C@](C)([N+]([O-])=O)C(OC)[C@@H](C)O7)=C4O)=O)C)=O)=C1O
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