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BGC0000140PKS

4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one

Producing organism
Streptomyces sp. 88-682
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
10
DOI
MIBiG entry
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4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
C21H36O5368.26 Da

Gene Cluster Map11 genes · 15,000 bp

CALKSATFkTE2 kb15.0 kb visible · 15,000 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
FkFkbH-like
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

10 steps · 8 edges
Step 1
Start
Step 4
rkC, rkG
+Malonyl-CoA
Step 5
Start
Step 2
rkA
Step 6
?
Step 3
rkB
Step 7
rkE
Step 8
?
Step 9
rkF
Step 10
rkD, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1140-1Start—
OC(CCCCCCCCCCCCCCC)=O—
2140-2rkA—
140-1
from: 140-1
[R]C(CCCCCCCCCCCCCCC)=O—
3140-3rkB—
140-2
from: 140-2
OC(CCCCCCCCCCCCCCC)=O—
4140-4rkC, rkG—
Malonyl-CoA
CCCCCCCCCCCCCCCC(CC(O)=O)=O—
5140-5Start—
OP([O-])(OC[C@@H](O)C(O)=O)=O—
6140-6?—
140-5
from: 140-5
OP([O-])(OC[C@@H](O)C(OP(O)([O-])=O)=O)=O—
7140-7rkE—
140-6
from: 140-6
OP([O-])(OC[C@@H](O)C([R])=O)=O—
8140-8?—
140-7
from: 140-7
OC[C@@H](O)C([R])=O—
9140-9rkF—
140-8
from: 140-8
OC[C@@H](O)C(O)=O—
10140rkD, ?—
140-4;140-9
from: 140-4, 140-9
CCCCCCCCCCCCCCCC(C1=C(O)[C@@H](CO)OC1=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture