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BGC0000138PKS

Rimocidin

Producing organism
Streptomyces diastaticus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces diastaticus group
Biosynthetic class
PKS (Unknown)
Total steps
17
DOI
MIBiG entry
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rimocidin
C39H61NO14767.41 Da

Gene Cluster Map11 genes · 19,055 bp

KRAKSATER5 kb19.1 kb visible · 19,055 bp total
Biosynthetic (core)
Biosynthetic (additional)
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
AAdenylation (A)
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1Load
rimA
+Butanoyl-CoA
Step 16
Start
+Mycosamine
Step 2M1
?
+Malonyl-CoA
Step 3M2
?
+Malonyl-CoA
Step 4M3
?
+Malonyl-CoA
Step 5M4
?
+Malonyl-CoA
Step 6M5
?
+Malonyl-CoA
Step 7M6
?
+Malonyl-CoA
Step 8M7
?
+Methylmalonyl-CoA
Step 9M8
?
+Malonyl-CoA
Step 10M9
?
+Malonyl-CoA
Step 11M10
?
+Malonyl-CoA
Step 12M11
?
+Malonyl-CoA
Step 13M12
?
+Malonyl-CoA
Step 14M13
?
+Ethylmalonyl-CoA
Step 15TE
?
Step 17
rimG, rimE
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1138-1rimALoading
Butanoyl-CoA
O=C(CCC)O—
2138-2?M1
138-1;Malonyl-CoA
from: 138-1
OC(CCC)CC(O)=O—
3138-3?M2
138-2;Malonyl-CoA
from: 138-2
OC(CCC)C/C=C/C(O)=O—
4138-4?M3
138-3;Malonyl-CoA
from: 138-3
OC(CCC)C/C=C/C=C/C(O)=O—
5138-5?M4
138-4;Malonyl-CoA
from: 138-4
OC(CCC)C/C=C/C=C/C=C/C(O)=O—
6138-6?M5
138-5;Malonyl-CoA
from: 138-5
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)=O—
7138-7?M6
138-6;Malonyl-CoA
from: 138-6
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)CC(O)=O—
8138-8?M7
138-7;Methylmalonyl-CoA
from: 138-7
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)=O—
9138-9?M8
138-8;Malonyl-CoA
from: 138-8
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(O)=O—
10138-10?M9
138-9;Malonyl-CoA
from: 138-9
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)=O)=O—
11138-11?M10
138-10;Malonyl-CoA
from: 138-10
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)CC(O)=O)=O—
12138-12?M11
138-11;Malonyl-CoA
from: 138-11
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)CCCC(O)=O)=O—
13138-13?M12
138-12;Malonyl-CoA
from: 138-12
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)CCCC(CC(O)=O)=O)=O—
14138-14?M13
138-13;Ethylmalonyl-CoA
from: 138-13
OC(CCC)C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C)C(O)CC(CC(O)CCCC(CC(O)C(CC)C(O)=O)=O)=O—
15138-15?TE
138-14
from: 138-14
OC(CCCC(CC(C(CC)C(OC(CCC)C/C=C/C=C/C=C/C=C/C(O)C1)=O)O)=O)CC2(O)OC1C(C)C(O)C2—
16138-16Start—
Mycosamine
O[C@H]1[C@H](O)O[C@@H](C)[C@H](O)[C@H]1N—
17138rimG, rimE—
138-15;138-16
from: 138-15, 138-16
OC(CCCC(CC(C(CC)C(OC(CCC)C/C=C/C=C/C=C/C=C/C(O[C@H]1[C@H](O)[C@H](N)[C@@H](O)[C@H](C)O1)C2)=O)O)=O)CC3(O)OC2C(C)C(O)C3—
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