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BGC0000137PKS

Rifamycin

Producing organism
Salinispora arenicola CNS-205
Taxonomy
Bacteria›Actinobacteria›Micromonosporales›Micromonosporaceae›Salinispora
Biosynthetic class
PKS (Unknown)
Total steps
31
DOI
MIBiG entry
—
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rifamycin
C37H47NO12697.31 Da

Pathway Graphsteps arranged in biosynthetic order

31 steps · 30 edges
Step 1
Start
+UDP-glucose
Step 2
Sare_1256
Step 3
Sare_1255
Step 4
Sare_1257
Step 5
Sare_1275
Step 6
?
Step 7
(Sare_1272, Sare_1273)?
Step 8
Sare_1254
Step 9
Sare_1253
Step 10
Sare_1277
Step 11
Sare_1255
Step 12Load
Sare_1246
Step 13M1
Sare_1246
+Methylmalonyl-CoA
Inactive: DH
Step 14M2
Sare_1246
+Malonyl-CoA
Step 15M3
Sare_1246
+Methylmalonyl-CoA
Inactive: KR
Step 16
Sare_1269
Step 17M4
Sare_1247
+Methylmalonyl-CoA
Step 18M5
Sare_1247
+Methylmalonyl-CoA
Inactive: DH
Step 19M6
Sare_1247
+Methylmalonyl-CoA
Inactive: DH
Step 20M7
Sare_1248
+Methylmalonyl-CoA
Inactive: DH
Step 21M8
Sare_1249
+Methylmalonyl-CoA
Inactive: DH
Step 22M9
Sare_1250
+Malonyl-CoA
Step 23M10
Sare_1250
+Methylmalonyl-CoA
Step 24
Sare_1251
Step 25
Sare_1243, ?
Step 26
Sare_1266, Sare_1268?
Step 27
Sare_1242?
Step 28
Sare_1259
Step 29
Sare_1260?
Step 30
Sare_1262?
Step 31
Sare_1271
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions31 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1137-1Start—
UDP-glucose
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
2137-2Sare_1256—
137-1
from: 137-1
O[C@H]1C([C@@H](O)[C@@H]([R])O[C@@H]1CO)=O—
3137-3Sare_1255—
137-2
from: 137-2
O[C@H]1[C@H](N)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
4137-4Sare_1257—
137-3
from: 137-3
O[C@H]1[C@H](N)[C@@H](O)[C@@H](O)O[C@@H]1CO—
5137-5Sare_1275—
137-4
from: 137-4
O[C@H]1[C@H](N)[C@@H](O)[C@@H](O)O[C@@H]1COP(O)(O)=O—
6137-6?—
137-5
from: 137-5
N[C@H]1[C@H](O)[C@H](O[C@@]1(CO)O)COP(O)(O)=O—
7137-7(Sare_1272, Sare_1273)?—
137-6
from: 137-6
[H][C@@](O)([C@](O)(COP(O)(O)=O)[H])C=N—
8137-8Sare_1254—
137-7
from: 137-7
[H][C@@](O)([C@](O)(COP(O)(O)=O)[H])[C@@]([H])(C([H])(C(C(O)=O)=O)[H])N—
9137-9Sare_1253—
137-8
from: 137-8
O=C1[C@@H](O)[C@H](N)C[C@](O)(C(O)=O)C1—
10137-10Sare_1277—
137-9
from: 137-9
O=C1[C@@H](O)[C@H](N)CC(C(O)=O)=C1—
11137-11Sare_1255—
137-10
from: 137-10
OC1=CC(N)=CC(C(O)=O)=C1—
12137-12Sare_1246Loading
137-11
from: 137-11
OC1=CC(N)=CC(C(O)=O)=C1—
13137-13Sare_1246M1
137-12;Methylmalonyl-CoA
from: 137-12
OC1=CC(N)=CC(C(O)C(C(O)=O)C)=C1{'Inactive': ['DH']}
14137-14Sare_1246M2
137-13;Malonyl-CoA
from: 137-13
OC1=CC(N)=CC(C(O)C(C(CC(O)=O)=O)C)=C1—
15137-15Sare_1246M3
137-14;Methylmalonyl-CoA
from: 137-14
OC1=CC(N)=CC(C(O)C(C(CC(C(C)C(O)=O)=O)=O)C)=C1{'Inactive': ['KR']}
16137-16Sare_1269—
137-15
from: 137-15
O=C(C(C(O)=O)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
17137-17Sare_1247M4
137-16;Methylmalonyl-CoA
from: 137-16
O=C(/C(C)=C/C(C(O)=O)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
18137-18Sare_1247M5
137-17;Methylmalonyl-CoA
from: 137-17
O=C(/C(C)=C/C(C(O)C(C(O)=O)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
19137-19Sare_1247M6
137-18;Methylmalonyl-CoA
from: 137-18
O=C(/C(C)=C/C(C(O)C(C(O)C(C(O)=O)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
20137-20Sare_1248M7
137-19;Methylmalonyl-CoA
from: 137-19
O=C(/C(C)=C/C(C(O)C(C(O)C(C(O)C(C(O)=O)C)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
21137-21Sare_1249M8
137-20;Methylmalonyl-CoA
from: 137-20
O=C(/C(C)=C/C(C(O)C(C(O)C(C(O)C(C(O)C(C(O)=O)C)C)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O{'Inactive': ['DH']}
22137-22Sare_1250M9
137-21;Malonyl-CoA
from: 137-21
O=C(/C(C)=C/C(C(O)C(C(O)C(C(O)C(C(O)C(/C=C/C(O)=O)C)C)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
23137-23Sare_1250M10
137-22;Methylmalonyl-CoA
from: 137-22
O=C(/C(C)=C/C(C(O)C(C(O)C(C(O)C(C(O)C(/C=C/C=C(C(O)=O)\C)C)C)C)C)C)C1=C(O)C(C)C(O)C(C(C(N)=C2)=O)=C1C2=O—
24137-24Sare_1251—
137-23
from: 137-23
CC1C(O)=C(C(/C(C)=C/C(C(C2C)O)C)=O)C(C(C=C(NC(/C(C)=C\C=C\C(C(O)C(C)C(O)C(C)C2O)C)=O)C3=O)=O)=C3C1O—
25137-25Sare_1243, ?—
137-24
from: 137-24
CC1=C(O)C2=C(C(C=C(NC(/C(C)=C\C=C\C(C(O)C(C)C(O)C(C)C3O)C)=O)C2=O)=O)C(C(/C(C)=C/C(C(C3C)O)C)=O)=C1O—
26137-26Sare_1266, Sare_1268?—
137-25
from: 137-25
CC1=C(O)C2=C(C(C=C(NC(/C(C)=C\C=C\C(C(O)C(C)C(O)C(C)C3O)C)=O)C2=O)=O)C(C(/C(C)=C/C(C(C3C)O)CO)=O)=C1O—
27137-27Sare_1242?—
137-26
from: 137-26
CC1=C(O)C2=C(C(C=C(NC(/C(C)=C\C=C\C(C(O)C(C)C(O)C(C)C3OC4=[R])C)=O)C2=O)=O)C(C(/C(C)=C/C4C(C3C)O)=O)=C1O—
28137-28Sare_1259—
137-27
from: 137-27
O=C1C(O/C=C/C(O)C(C)C(O)C(C)C(O)C(C)C(O)C(C)/C=C/C=C2/C)(C)OC3=C1C(C(C=C4NC2=O)=O)=C(C(O)=C3C)C4=O—
29137-29Sare_1260?—
137-28
from: 137-28
O=C1C(O/C=C/C(O)C(C)C(O)C(C)C(O)C(C)C(O)C(C)/C=C/C=C2/C)(C)OC3=C1C(C(O)=C4)=C(C(O)=C3C)C(O)=C4NC2=O—
30137-30Sare_1262?—
137-29
from: 137-29
O=C1C(O/C=C/C(O)C(C)C(OC(C)=O)C(C)C(O)C(C)C(O)C(C)/C=C/C=C2/C)(C)OC3=C1C(C(O)=C4)=C(C(O)=C3C)C(O)=C4NC2=O—
31137Sare_1271—
137-30
from: 137-30
O=C1C(O/C=C/C(OC)C(C)C(OC(C)=O)C(C)C(O)C(C)C(O)C(C)/C=C/C=C2/C)(C)OC3=C1C(C(O)=C4)=C(C(O)=C3C)C(O)=C4NC2=O—
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