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BGC0000135PKS

Reveromycin A

Producing organism
Streptomyces sp. SN-593
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
14
DOI
MIBiG entry
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reveromycin A
C36H52O11660.35 Da

Gene Cluster Map33 genes · 104,853 bp

20 kb104.9 kb visible · 104,853 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1Load
revC
+Methylmalonyl-CoA
Step 2M1
revC
+Malonyl-CoA
Inactive: DH
Step 3M2
revC
+Methylmalonyl-CoA
Step 4M3
revC
+Malonyl-CoA
Step 5M4
revA
+Butylmalonyl-CoA
Step 6M5
revA
+Malonyl-CoA
Step 7M6
revA
+Malonyl-CoA
Step 8M7
revB
+Methylmalonyl-CoA
Step 9M8
revB
+Malonyl-CoA
Step 10M9
revD
+Methylmalonyl-CoA
Step 11M10
revD
+Malonyl-CoA
Step 12M11
revD
+Methylmalonyl-CoA
Step 13M12
revD
+Malonyl-CoA
Step 14TE
revD
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1135-1revCLoading
Methylmalonyl-CoA
CCC(O)=O—
2135-2revCM1
135-1;Malonyl-CoA
from: 135-1
CCC(O)CC(O)=O{'Inactive': ['DH']}
3135-3revCM2
135-2;Methylmalonyl-CoA
from: 135-2
CCC(O)C/C=C(C)/C(O)=O—
4135-4revCM3
135-3;Malonyl-CoA
from: 135-3
CCC(O)C/C=C(C)/C=C/C(O)=O—
5135-5revAM4
135-4;Butylmalonyl-CoA
from: 135-4
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)C(O)=O—
6135-6revAM5
135-5;Malonyl-CoA
from: 135-5
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)CCC(O)=O—
7135-7revAM6
135-6;Malonyl-CoA
from: 135-6
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)CCC(O)CC(O)=O—
8135-8revBM7
135-7;Methylmalonyl-CoA
from: 135-7
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)CCC(O)CCC(C)C(O)=O—
9135-9revBM8
135-8;Malonyl-CoA
from: 135-8
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)CCC(O)CCC(C)C(O)CC(O)=O—
10135-10revDM9
135-9;Methylmalonyl-CoA
from: 135-9
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)CCC(O)CCC(C)C(O)C/C=C(C)/C(O)=O—
11135-11revDM10
135-10;Malonyl-CoA
from: 135-10
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)CCC(O)CCC(C)C(O)C/C=C(C)/C=C/C(O)=O—
12135-12revDM11
135-11;Methylmalonyl-CoA
from: 135-11
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)CCC(O)CCC(C)C(O)C/C=C(C)/C=C/C(O)C(C)C(O)=O—
13135-13revDM12
135-12;Malonyl-CoA
from: 135-12
CCC(O)C/C=C(C)/C=C/C(O)C(CCCC)CCC(O)CCC(C)C(O)C/C=C(C)/C=C/C(O)C(C)/C=C/C(O)=O—
14135revDTE
135-13
from: 135-13
CC(/C=C/[C@H](O)[C@@H](C)/C=C/C(O)=O)=C\C[C@@]1(C)O[C@@]2(CC[C@@](CCCC)(OC(CCC(O)=O)=O)C(/C=C/C(C)=C/C(O)=O)O2)CC[C@@H]1C—
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