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BGC0000133PKS

Quartromicin A1

Producing organism
Amycolatopsis orientalis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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quartromicin A1
C77H102O301506.65 Da

Gene Cluster Map36 genes · 82,338 bp

KSKSKSKSKSKS20 kb82.3 kb visible · 82,338 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

18 steps · 20 edges
Step 1Load
AFI57005.1
+Malonyl-CoA
Step 8
Start
+1,3-Bisphosphogly…
Step 17
Start
+α-D-galactopyrano…
Step 2M1
AFI57005.1
+Methylmalonyl-CoA
Step 9
AFI57024.1;AFI57025.1
Step 3M2
AFI57005.1
+Methylmalonyl-CoA
Step 4M3
AFI57005.1
+Malonyl-CoA
Step 5M4
AFI57006.1
+Methylmalonyl-CoA
Step 7M5
AFI57007.1
+Malonyl-CoA
Step 6M5
AFI57007.1
+Malonyl-CoA
Step 11
AFI57023.1
Step 10
AFI57023.1
Step 13
AFI57004.1, AFI57026.1?
Step 12
AFI57004.1, AFI57026.1?
Step 14
?
Step 15
?
Step 16
?
+(133-14
Step 18
AFI57027.1, AFI57011.1,…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1133-1AFI57005.1Loading
Malonyl-CoA
O=C(C)O—
2133-2AFI57005.1M1
133-1;Methylmalonyl-CoA
from: 133-1
C/C=C(C)/C(O)=O—
3133-3AFI57005.1M2
133-2;Methylmalonyl-CoA
from: 133-2
C/C=C(C)/C=C(C)/C(O)=O—
4133-4AFI57005.1M3
133-3;Malonyl-CoA
from: 133-3
C/C=C(C)/C=C(C)/C=C/C(O)=O—
5133-5AFI57006.1M4
133-4;Methylmalonyl-CoA
from: 133-4
C/C=C(C)/C=C(C)/C=C/C=C(C)/C(O)=O—
6133-6AFI57007.1M5
133-5;Malonyl-CoA
from: 133-5
C/C=C(C)/C=C(C)/C=C/C=C(C)/C(CC(O)=O)=O—
7133-7AFI57007.1M5
133-4;Malonyl-CoA
from: 133-4
C/C=C(C)/C=C(C)/C=C/C(CC(O)=O)=O—
8133-8Start—
1,3-Bisphosphoglyceric acid
O[C@@H](C(OP(O)(O)=O)=O)COP(O)(O)=O—
9133-9AFI57024.1;AFI57025.1—
133-8
from: 133-8
O[C@H](CO)C(O)=O—
10133-10AFI57023.1—
133-6;133-9
from: 133-6, 133-9
O=C(/C(C)=C/C=C/C(C)=C/C(C)=C/C)C1=C(O)C(CO)OC1=O—
11133-11AFI57023.1—
133-7;133-9
from: 133-7, 133-9
O=C(/C=C/C(C)=C/C(C)=C/C)C1=C(O)C(CO)OC1=O—
12133-12AFI57004.1, AFI57026.1?—
133-10
from: 133-10
O=C(/C(C)=C/C=C/C(C)=C/C(C)=C/C)C(C(O1)=O)=C(O)C1=C—
13133-13AFI57004.1, AFI57026.1?—
133-11
from: 133-11
O=C(/C=C/C(C)=C/C(C)=C/C)C(C(O1)=O)=C(O)C1=C—
14133-14?—
133-12;133-13
from: 133-12, 133-13
O=C(/C(C)=C/C=C/[C@@]1(C)C=C(C)[C@@H](C)C[C@@]12C(O)=C(C(/C=C/C(C)=C/C(C)=C/C)=O)C(O2)=O)C(C(O3)=O)=C(O)C3=C—
15133-15?—
133-12;133-13
from: 133-12, 133-13
O=C(/C(C)=C/C=C/[C@@]1(C)C=C(C)[C@@H](C)C[C@]12C(O)=C(C(/C=C/C(C)=C/C(C)=C/C)=O)C(O2)=O)C(C(O3)=O)=C(O)C3=C—
16133-16?—
(133-14;133-14)/(133-15;133-15)
from: 133-14)/(133-15, 133-15)
O=C(/C(C)=C/C=C/[C@@]1(C)C=C(C)[C@@H](C)C[C@@]12C(O)=C(C(/C=C/[C@@]3(C)C=C(C)C[C@@]4(OC(C(C(/C(C)=C/C=C/[C@@]5(C)C=C(C)[C@@H](C)C[C@@]56C(O)=C(C(/C=C/[C@@]7(C)C=C(C)[C@@H](C)C8)=O)C(O6)=O)=O)=C4O)=O)C3)=O)C(O2)=O)C9=C(O)[C@]78OC9=O—
17133-17Start—
α-D-galactopyranose
O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1—
18133AFI57027.1, AFI57011.1, ?—
133-16;133-17;133-17
from: 133-16, 133-17, 133-17
CC1CC23C(C=C1CO[C@@H]4[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O4)C=CC=C(C)C(O)C5C([O-])OC6(CC(C)C(C=O)=CC6(C)C=CC(O)C7C([O-])OC8(CC(C)C(CO[C@@H]9[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O9)=CC8(C)C=CC=C(C)C(O)C%10C([O-])OC%11(CC(C)C(C=O)=CC%11(C)C=CC(O)C(C([O-])O3)C2=O)C%10=O)C7=O)C5=O.[M+].[M+].[M+].[M+]—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture