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BGC0000130PKS

Pyrrolomycin A;Pyrrolomycin B;Pyrrolomycin C;Pyrrolomycin D

Producing organism
Wenjunlia vitaminophila
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Wenjunlia
Biosynthetic class
PKS (Unknown)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
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C4H2Cl2N2O2179.95 Da

Gene Cluster Map35 genes · 55,655 bp

AKSATKSATKS10 kb55.7 kb visible · 55,655 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TDTerminal reductase
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1
pyr8;pyr28
+L-Proline
Step 2
pyr7
Step 3
pyr29
Step 4M1
pyr25
+Malonyl-CoA
Step 5M2
pyr25
+Malonyl-CoA
{'Missing':["AT', 'KR']}
Step 6M3
pyr24
+Malonyl-CoA
Inactive: DH
Step 7
?
Step 8
?
Step 9
?
+130(1)
Step 10
?
+130(1)
Step 11
?
Step 12
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1130-1pyr8;pyr28—
L-Proline
O=C([C@@H]1CCCN1)O—
2130-2pyr7—
130-1
from: 130-1
O=C(C1=CC=CN1)O—
3130-3pyr29—
130-2
from: 130-2
O=C(C1=CC(Cl)=C(Cl)N1)O—
4130-4pyr25M1
130-3;Malonyl-CoA
from: 130-3
ClC(NC(C(CC(O)=O)=O)=C1)=C1Cl—
5130-5pyr25M2
130-4;Malonyl-CoA
from: 130-4
ClC(NC(C(CC(O)CC(O)=O)=O)=C1)=C1Cl{'Missing':["AT', 'KR']}
6130-6pyr24M3
130-5;Malonyl-CoA
from: 130-5
ClC(NC(C(CC(O)CC(O)CC(O)=O)=O)=C1)=C1Cl{'Inactive': ['DH']}
7130-7?—
130-6
from: 130-6
O=C(C1=CC(Cl)=C(Cl)N1)C2=C(O)C=CC=C2—
8130(1)?—
130-7
from: 130-7
O=C(C1=CC(Cl)=C(Cl)N1)C2=C(O)C(Cl)=CC(Cl)=C2—
9130(2)?—
130(1)
O=C(C1=C(Cl)C(Cl)=C(Cl)N1)C2=C(O)C(Cl)=CC(Cl)=C2—
10130-8?—
130(1)
OC(C1=C([N+]([O-])=O)C(Cl)=C(Cl)N1)C2=C(O)C(Cl)=CC(Cl)=C2—
11130(3)?—
130-8
from: 130-8
ClC(N1)=C(Cl)C([N+]([O-])=O)=C1CC2=C(O)C(Cl)=CC(Cl)=C2—
12130(4)?—
130-3/130(3)
from: 130-3/130(3)
ClC1=C(Cl)NC=C1[N+]([O-])=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture