NPdia
← Back to Repository
BGC0000126PKS

Pladienolide B

Producing organism
Streptomyces platensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
Loading…
pladienolide B
C30H48O8536.33 Da

Gene Cluster Map8 genes · 74,342 bp

KSKSKSKSKSKSKSKSKSKSKS10 kb74.3 kb visible · 74,342 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1Load
pldAI
+Methylmalonyl-CoA
Step 2M1
pldAI
+Methylmalonyl-CoA
Step 3M2
pldAI
+Malonyl-CoA
Step 4M3
pldAI
+Methylmalonyl-CoA
Step 5M4
pldAII
+Malonyl-CoA
Step 6M5
pldAII
+Methylmalonyl-CoA
Step 7M6
pldAII
+Methylmalonyl-CoA
Step 8M7
pldAII
+Malonyl-CoA
Step 9M8
pldAIII
+Methylmalonyl-CoA
Step 10M9
pldAIII
+Malonyl-CoA
Step 11M10
pldAIV
+Malonyl-CoA
Step 12TE
pldAIV, (pldB, pldC, pl…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1126-1pldAILoading
Methylmalonyl-CoA
O=C(O)CC—
2126-2pldAIM1
126-1;Methylmalonyl-CoA
from: 126-1
OC(C(C)C(O)=O)CC—
3126-3pldAIM2
126-2;Malonyl-CoA
from: 126-2
OC(C(C)/C=C/C(O)=O)CC—
4126-4pldAIM3
126-3;Methylmalonyl-CoA
from: 126-3
OC(C(C)/C=C/CC(C)C(O)=O)CC—
5126-5pldAIIM4
126-4;Malonyl-CoA
from: 126-4
OC(C(C)/C=C/CC(C)/C=C/C(O)=O)CC—
6126-6pldAIIM5
126-5;Methylmalonyl-CoA
from: 126-5
OC(C(C)/C=C/CC(C)/C=C/C=C(C(O)=O)\C)CC—
7126-7pldAIIM6
126-6;Methylmalonyl-CoA
from: 126-6
OC(C(C)/C=C/CC(C)/C=C/C=C(C(O)C(C(O)=O)C)\C)CC—
8126-8pldAIIM7
126-7;Malonyl-CoA
from: 126-7
OC(C(C)/C=C/CC(C)/C=C/C=C(C(O)C(/C=C/C(O)=O)C)\C)CC—
9126-9pldAIIIM8
126-8;Methylmalonyl-CoA
from: 126-8
OC(C(C)/C=C/CC(C)/C=C/C=C(C(O)C(/C=C/C(O)C(C(O)=O)C)C)\C)CC—
10126-10pldAIIIM9
126-9;Malonyl-CoA
from: 126-9
OC(C(C)/C=C/CC(C)/C=C/C=C(C(O)C(/C=C/C(O)C(CCC(O)=O)C)C)\C)CC—
11126-11pldAIVM10
126-10;Malonyl-CoA
from: 126-10
OC(C(C)/C=C/CC(C)/C=C/C=C(C(O)C(/C=C/C(O)C(CCC(O)CC(O)=O)C)C)\C)CC—
12126pldAIV, (pldB, pldC, pldD)TE
126-11
from: 126-11
C/C(C(C(C)/C=C/C(OC(C)=O)C(C)(O)CCC(O)C1)OC1=O)=C\C=C\C(CC2C(O2)C(C(CC)O)C)C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture