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BGC0000125PKS

Pimaricin

Producing organism: Streptomyces natalensis
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Unknown)
Total steps: 16
DOI: 10.1016/S1074-5521(00)00038-7
MIBiG entry: View on MIBiG ↗

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pimaricin

C₃₃H₄₇NO₁₃665.30 Da

Gene Cluster Map17 genes · 84,985 bp

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Other

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Adenylation (A)

Thioesterase (TE)

Docking N-term

Docking C-term

Aminotransferase V

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`125-1`	pimS0	Loading	Acetyl-CoA	`O=C(O)C`	{'Inactive': ['KS']}
2	`125-2`	pimS1	M1	125-1;Malonyl-CoA from: 125-1	`OC(CC(O)=O)C`	—
3	`125-3`	pimS1	M2	125-2;Malonyl-CoA from: 125-2	`OC(C/C=C/C(O)=O)C`	—
4	`125-4`	pimS1	M3	125-3;Malonyl-CoA from: 125-3	`OC(C/C=C/C=C/C(O)=O)C`	—
5	`125-5`	pimS1	M4	125-4;Malonyl-CoA from: 125-4	`OC(C/C=C/C=C/C=C/C(O)=O)C`	—
6	`125-6`	pimS2	M5	125-5;Malonyl-CoA from: 125-5	`OC(C/C=C/C=C/C=C/C=C/C(O)=O)C`	—
7	`125-7`	pimS2	M6	125-6;Malonyl-CoA from: 125-6	`OC(C/C=C/C=C/C=C/C=C/C(O)CC(O)=O)C`	—
8	`125-8`	pimS2	M7	125-7;Methylmalonyl-CoA from: 125-7	`OC(C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C(O)=O)C)C`	—
9	`125-9`	pimS2	M8	125-8;Malonyl-CoA from: 125-8	`OC(C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C(O)CC(O)=O)C)C`	—
10	`125-10`	pimS2	M9	125-9;Malonyl-CoA from: 125-9	`OC(C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C(O)CC(CC(O)=O)=O)C)C`	{'Inactive': ['KR']}
11	`125-11`	pimS2	M10	125-10;Malonyl-CoA from: 125-10	`OC(C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C(O)CC(CC(O)CC(O)=O)=O)C)C`	—
12	`125-12`	pimS3	M11	125-11;Malonyl-CoA from: 125-11	`OC(C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C(O)CC(CC(O)C/C=C/C(O)=O)=O)C)C`	—
13	`125-13`	pimS4	M12	125-12;Malonyl-CoA from: 125-12	`OC(C/C=C/C=C/C=C/C=C/C(O)CC(O)C(C(O)CC(CC(O)C/C=C/C=C/C(O)=O)=O)C)C`	—
14	`125-14`	pimS4	TE	125-13 from: 125-13	`OC(CC(O1)C1/C=C/C(OC(C)C/C=C/C=C/C=C/C=C/C(O)C2)=O)CC3(O)OC2C(C(O)=O)C(O)C3`	—
15	`125-15`	Start	—	Mycosamine	`OC1C(O)C(N)C(O)C(C)O1`	—
16	`125`	pimK	—	125-14;125-15 from: 125-14, 125-15	`OC(CC(O1)C1/C=C/C(OC(C)C/C=C/C=C/C=C/C=C/C(OC2C(O)C(N)C(O)C(C)O2)C3)=O)CC4(O)OC3C(C(O)=O)C(O)C4`	—

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