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BGC0000118PKS

pactamycin

Producing organism
Streptomyces pactum
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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pactamycin
C28H38N4O8558.27 Da

Gene Cluster Map28 genes · 42,898 bp

KSKSATAAmT10 kb42.9 kb visible · 42,898 bp total
Biosynthetic (core)
Biosynthetic (additional)
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
AmTAminotransferase III

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1
Start
+3-Dehydroshikimate
Step 5
Start
+N-acetylglucosami…
Step 17
pctK;pctS;pctT
Iterative
Step 2
pctC
Step 6
pctL
Step 3
pctU
Step 4
pctQ
Step 7
pctI
Step 8
pctE/pctP
Step 9
pctE/pctP
Step 10
pctV
Step 11
pctJ/pctN/pctO
Step 12
pctJ/pctN/pctO
Step 13
pctJ/pctN/pctO
Step 14
pctA;pctB
Step 15
pctD
Step 16
pctF
Step 18
pctM
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1118-1Start—
3-Dehydroshikimate
O=C1C=C(C(O)=O)C[C@@H](O)[C@@H]1O—
2118-2pctC—
118-1
from: 118-1
NC1=CC=CC(C(O)=O)=C1—
3118-3pctU—
118-2
from: 118-2
NC1=CC(C(CC([R])=O)=O)=CC=C1—
4118-4pctQ—
118-3
from: 118-3
NC1=CC(C(C)=O)=CC=C1—
5118-5Start—
N-acetylglucosamine
O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@@H]([R])O[C@@H]1CO—
6118-6pctL—
118-5
from: 118-5
O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](NC2=CC=CC(C(C)=O)=C2)O[C@@H]1CO—
7118-7pctI—
118-4;118-6
from: 118-4, 118-6
O[C@H]1[C@H](O)[C@@H](N)[C@H](NC2=CC=CC(C(C)=O)=C2)O[C@@H]1CO—
8118-8pctE/pctP—
118-7
from: 118-7
O[C@@H]1[C@@H](N)[C@H](NC2=CC=CC(C(C)=O)=C2)[C@](O)(CO)C1=O—
9118-9pctE/pctP—
118-8
from: 118-8
O=C1[C@@H](N)[C@H](NC2=CC=CC(C(C)=O)=C2)[C@](O)(CO)[C@@H]1O—
10118-10pctV—
118-9
from: 118-9
N[C@@H]1[C@H](N)[C@@H](O)[C@@](O)(CO)[C@H]1NC2=CC=CC(C(C)=O)=C2—
11118-11pctJ/pctN/pctO—
118-10
from: 118-10
N[C@@H]1[C@H](N)[C@](O)(C)[C@@](O)(CO)[C@H]1NC2=CC=CC(C(C)=O)=C2—
12118-12pctJ/pctN/pctO—
118-11
from: 118-11
N[C@@H]1[C@@](N)(C)[C@](O)(C)[C@@](O)(CO)[C@H]1NC2=CC=CC(C(C)=O)=C2—
13118-13pctJ/pctN/pctO—
118-12
from: 118-12
N[C@@H]1[C@@](N)(CC)[C@](O)(C)[C@@](O)(CO)[C@H]1NC2=CC=CC(C(C)=O)=C2—
14118-14pctA;pctB—
118-13
from: 118-13
N[C@@H]1[C@@](N)([C@@H](O)C)[C@](O)(C)[C@@](O)(CO)[C@H]1NC2=CC=CC(C(C)=O)=C2—
15118-15pctD—
118-14
from: 118-14
N[C@@H]1[C@@](NC(N)=O)([C@@H](O)C)[C@](O)(C)[C@@](O)(CO)[C@H]1NC2=CC=CC(C(C)=O)=C2—
16118-16pctF—
118-15
from: 118-15
N[C@@H]1[C@@](NC(NC)=O)([C@@H](O)C)[C@](O)(C)[C@@](O)(CO)[C@H]1NC2=CC=CC(C(C)=O)=C2—
17118-17pctK;pctS;pctT—
CC1=C(C(O)=O)C(O)=CC=C1{'Iteration': [(['None'], 'A…
18118pctM—
118-16;118-17
from: 118-16, 118-17
N[C@@H]1[C@@](NC(NC)=O)([C@@H](O)C)[C@](O)(C)[C@@](O)(COC(C2=C(C)C=CC=C2O)=O)[C@H]1NC3=CC=CC(C(C)=O)=C3—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture