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BGC0000116PKS

nystatin-like Pseudonocardia polyene A1

Producing organism
Pseudonocardia autotrophica
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Pseudonocardia
Biosynthetic class
PKS (Unknown)
Total steps
26
DOI
MIBiG entry
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nystatin-like Pseudonocardia polyene A1
C55H88N2O221129.30 Da

Gene Cluster Map23 genes · 125,717 bp

20 kb125.7 kb visible · 125,717 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

26 steps · 25 edges
Step 1Load
cppA
+Malonyl-CoA
Step 22
Start
Step 24
Start
Step 2M1
cppB
+Methylmalonyl-CoA
Step 3M2
cppB
+Methylmalonyl-CoA
Step 4M3
cppC
+Malonyl-CoA
Step 5M4
cppC
+Malonyl-CoA
Step 6M5
cppC
+Malonyl-CoA
Step 7M6
cppC
+Malonyl-CoA
Step 8M7
cppC
+Malonyl-CoA
Step 9M8
cppC
+Malonyl-CoA
Step 10M9
cppI
+Malonyl-CoA
Step 11M10
cppI
+Malonyl-CoA
Step 12M11
cppI
+Methylmalonyl-CoA
Step 13M12
cppI
+Malonyl-CoA
Step 14M13
cppI
+Malonyl-CoA
Inactive: KR
Step 15M14
cppI
+Malonyl-CoA
Step 16M15
cppJ
+Malonyl-CoA
Step 17M16
cppJ
+Malonyl-CoA
Step 18M17
cppJ
+Malonyl-CoA
Inactive: DH
Step 19M18
cppK
+Malonyl-CoA
Inactive: DH
Step 20TE
cppK
Step 21
cppN
Step 23
cppDI
Step 25
cppDII
Step 26
cppL
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions26 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1116-1cppALoading
Malonyl-CoA
OC(C)=O—
2116-2cppBM1
Methylmalonyl-CoA;116-1
from: 116-1
C[C@H](O)[C@H](C)C(O)=O—
3116-3cppBM2
Methylmalonyl-CoA;116-2
from: 116-2
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)C(O)=O—
4116-4cppCM3
Malonyl-CoA;116-3
from: 116-3
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C(O)=O—
5116-5cppCM4
Malonyl-CoA;116-4
from: 116-4
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/C(O)=O—
6116-6cppCM5
Malonyl-CoA;116-5
from: 116-5
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CCC(O)=O—
7116-7cppCM6
Malonyl-CoA;116-6
from: 116-6
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C(O)=O—
8116-8cppCM7
Malonyl-CoA;116-7
from: 116-7
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C(O)=O—
9116-9cppCM8
Malonyl-CoA;116-8
from: 116-8
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C(O)=O—
10116-10cppIM9
Malonyl-CoA;116-9
from: 116-9
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(O)=O—
11116-11cppIM10
Malonyl-CoA;116-10
from: 116-10
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)CC(O)=O—
12116-12cppIM11
Methylmalonyl-CoA;116-11
from: 116-11
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)C(O)=O—
13116-13cppIM12
Malonyl-CoA;116-12
from: 116-12
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(O)=O—
14116-14cppIM13
Malonyl-CoA;116-13
from: 116-13
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(CC(O)=O)=O{'Inactive': ['KR']}
15116-15cppIM14
Malonyl-CoA;116-14
from: 116-14
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CC(O)=O)=O—
16116-16cppJM15
Malonyl-CoA;116-15
from: 116-15
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCCC(O)=O)=O—
17116-17cppJM16
Malonyl-CoA;116-16
from: 116-16
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)CC(O)=O)=O—
18116-18cppJM17
Malonyl-CoA;116-17
from: 116-17
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)C[C@H](O)CC(O)=O)=O{'Inactive': ['DH']}
19116-19cppKM18
Malonyl-CoA;116-18
from: 116-18
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O)=O{'Inactive': ['DH']}
20116-20cppKTE
116-19
from: 116-19
O[C@H](CC1[C@H](C)[C@@H](O)C[C@](C[C@@H](O)CCC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]2O)=O)(O)O1)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]2C—
21116-21cppN—
116-20
from: 116-20
O[C@H](CC1[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)CCC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]2O)=O)(O)O1)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]2C—
22116-22Start—
O[C@@H]1[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O1—
23116-23cppDI—
116-21;116-22
from: 116-21, 116-22
O[C@@H](C[C@](C[C@@H](O)CCC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]1O)=O)(O)O2)[C@@H](C(O)=O)C2C[C@@H](O[C@@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]1C—
24116-24Start—
O[C@@H]1O[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]1NC(C)=O—
25116-25cppDII—
116-23;116-24
from: 116-23, 116-24
O[C@@H](C[C@](C[C@@H](O)CCC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]1O)=O)(O)O2)[C@@H](C(O)=O)C2C[C@@H](O[C@@H]3[C@@H](O)[C@@H](N)[C@H](O[C@@H]4O[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]4NC(C)=O)[C@@H](C)O3)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]1C—
26116cppL—
116-25
from: 116-25
O[C@@H](C[C@](C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]1O)=O)(O)O2)[C@@H](C(O)=O)C2C[C@@H](O[C@@H]3[C@@H](O)[C@@H](N)[C@H](O[C@@H]4O[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]4NC(C)=O)[C@@H](C)O3)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]1C—
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