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BGC0000115PKS

nystatin A1

Producing organism
Streptomyces noursei ATCC 11455
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I);saccharide (hybrid/tailoring)
Total steps
23
DOI
MIBiG entry
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nystatin A1
C47H75NO17925.50 Da

Gene Cluster Map22 genes · 123,580 bp

20 kb123.6 kb visible · 123,580 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

23 steps · 22 edges
Step 1Load
nysA
+Malonyl-CoA
Step 22
nysDI,nysDII,nysDIII
+L-Fructose-6-phos…
Step 2M1
nysB
+Methylmalonyl-CoA
Step 3M2
nysB
+Methylmalonyl-CoA
Step 4M3
nysC
+Malonyl-CoA
Step 5M4
nysC
+Malonyl-CoA
Step 6M5
nysC
+Malonyl-CoA
Step 7M6
nysC
+Malonyl-CoA
Step 8M7
nysC
+Malonyl-CoA
Step 9M8
nysC
+Malonyl-CoA
Step 10M9
nysI
+Malonyl-CoA
Step 11M10
nysI
+Malonyl-CoA
Step 12M11
nysI
+Methylmalonyl-CoA
Step 13M12
nysI
+Malonyl-CoA
Step 14M13
nysI
+Malonyl-CoA
Inactive: KR
Step 15M14
nysI
+Malonyl-CoA
Step 16M15
nysJ
+Malonyl-CoA
Step 17M16
nysJ
+Malonyl-CoA
Step 18M17
nysJ
+Malonyl-CoA
Inactive: DH
Step 19M18
nysK
+Malonyl-CoA
Inactive: DH
Step 20TE
nysK
Step 21
nysL,nysN
Step 23
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions23 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1115-1nysALoading
Malonyl-CoA
OC(C)=O—
2115-2nysBM1
Methylmalonyl-CoA;115-1
from: 115-1
C[C@H](O)[C@H](C)C(O)=O—
3115-3nysBM2
Methylmalonyl-CoA;115-2
from: 115-2
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)C(O)=O—
4115-4nysCM3
Malonyl-CoA;115-3
from: 115-3
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C(O)=O—
5115-5nysCM4
Malonyl-CoA;115-4
from: 115-4
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/C(O)=O—
6115-6nysCM5
Malonyl-CoA;115-5
from: 115-5
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CCC(O)=O—
7115-7nysCM6
Malonyl-CoA;115-6
from: 115-6
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C(O)=O—
8115-8nysCM7
Malonyl-CoA;115-7
from: 115-7
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C(O)=O—
9115-9nysCM8
Malonyl-CoA;115-8
from: 115-8
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C(O)=O—
10115-10nysIM9
Malonyl-CoA;115-9
from: 115-9
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(O)=O—
11115-11nysIM10
Malonyl-CoA;115-10
from: 115-10
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)CC(O)=O—
12115-12nysIM11
Methylmalonyl-CoA;115-11
from: 115-11
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)C(O)=O—
13115-13nysIM12
Malonyl-CoA;115-12
from: 115-12
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(O)=O—
14115-14nysIM13
Malonyl-CoA;115-13
from: 115-13
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(CC(O)=O)=O{'Inactive': ['KR']}
15115-15nysIM14
Malonyl-CoA;115-14
from: 115-14
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CC(O)=O)=O—
16115-16nysJM15
Malonyl-CoA;115-15
from: 115-15
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCCC(O)=O)=O—
17115-17nysJM16
Malonyl-CoA;115-16
from: 115-16
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)CC(O)=O)=O—
18115-18nysJM17
Malonyl-CoA;115-17
from: 115-17
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)C[C@H](O)CC(O)=O)=O{'Inactive': ['DH']}
19115-19nysKM18
Malonyl-CoA;115-18
from: 115-18
C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O)C[C@@H](O)[C@@H](C)[C@@H](O)CC(C[C@H](O)CCC[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O)=O{'Inactive': ['DH']}
20115-20nysKTE
115-19
from: 115-19
O[C@H](CC1[C@H](C)[C@@H](O)C[C@](C[C@@H](O)CCC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]2O)=O)(O)O1)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]2C—
21115-21nysL,nysN—
115-20
from: 115-20
O[C@H](CC1[C@H](C(O)=O)[C@@H](O)C[C@](C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]2O)=O)(O)O1)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]2C—
22115-22nysDI,nysDII,nysDIII—
L-Fructose-6-phosphate
O[C@@H]1[C@@H](O)[C@@H](N)[C@H](O)[C@H](C)O1—
23115?—
115-21;115-22
from: 115-21, 115-22
O[C@@H](C[C@](C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O[C@@H](C)[C@H](C)[C@@H]1O)=O)(O)O2)[C@@H](C(O)=O)C2C[C@@H](O[C@@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@H](C)O3)/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]1C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture