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BGC0000114PKS

nigericin

Producing organism: Streptomyces violaceusniger
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces violaceusniger group
Biosynthetic class: PKS (Type I)
Total steps: 20
DOI: 10.1016/j.chembiol.2007.05.011 10.1016/j.nbt.2025.02.002
MIBiG entry: View on MIBiG ↗

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nigericin

C₄₀H₆₈O₁₁724.48 Da

Gene Cluster Map18 genes · 95,700 bp

Biosynthetic (core)

Biosynthetic (additional)

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Docking N-term

Docking C-term

Methyltransferase

Pathway Graphsteps arranged in biosynthetic order

20 steps · 19 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions20 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`114-1`	ABC84456.1	M1	Malonyl-CoA	`OC(C)=O`	—
2	`114-2`	ABC84456.1	M2	Methylmalonyl-CoA;114-1 from: 114-1	`CC(C(C)C(O)=O)=O`	—
3	`114-3`	ABC84457.1	M3	Methylmalonyl-CoA;114-2 from: 114-2	`CC(C(C)CC(C)C(O)=O)=O`	—
4	`114-4`	ABC84458.1	M4	Malonyl-CoA;114-3 from: 114-3	`CC(C(C)CC(C)/C=C/C(O)=O)=O`	—
5	`114-5`	ABC84458.1	M5	Methylmalonyl-CoA;114-4 from: 114-4	`CC(C(C)CC(C)/C=C/CC(C)C(O)=O)=O`	—
6	`114-6`	ABC84459.1	M6	Methylmalonyl-CoA;114-5 from: 114-5	`CC(C(C)CC(C)/C=C/CC(C)/C=C(C)/C(O)=O)=O`	—
7	`114-7`	ABC84459.1	M7	Malonyl-CoA;114-6 from: 114-6	`CC(C(C)CC(C)/C=C/CC(C)/C=C(C)/CCC(O)=O)=O`	—
8	`114-8`	ABC84460.1	M8	Methylmalonyl-CoA;114-7 from: 114-7	`CC(C(C)CC(C)/C=C/CC(C)/C=C(C)/CC/C=C(C)/C(O)=O)=O`	—
9	`114-9`	ABC84460.1	M9	Methylmalonyl-CoA;114-8 from: 114-8	`CC(C(C)CC(C)/C=C/CC(C)/C=C(C)/CC/C=C(C)/CC(C)C(O)=O)=O`	—
10	`114-10`	ABC84461.1	M10	Methylmalonyl-CoA;114-9 from: 114-9	`CC(C(C)CC(C)/C=C/CC(C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)C(O)=O)=O)=O`	{'Inactive': ['KR']}
11	`114-11`	ABC84471.1	M11	Malonyl-CoA;114-10 from: 114-10	`CC(C(C)CC(C)/C=C/CC(C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)C(O)CC(O)=O)=O)=O`	—
12	`114-12`	ABC84471.1	M12	Malonyl-CoA;114-11 from: 114-11	`OC(CC(O)CC(O)C(C)C(C(C)C/C(C)=C/CC/C(C)=C/C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O`	—
13	`114-13`	ABC84471.1	M13	Malonyl-CoA;114-12 from: 114-12	`CC(C(C)CC(C)/C=C/CC(C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)C(O)CC(O)CC(O)CC(O)=O)=O)=O`	—
14	`114-14`	ABC84470.1	M14	Methylmalonyl-CoA;114-13 from: 114-13	`OC(C(C)CCC(O)CC(O)CC(O)C(C)C(C(C)C/C(C)=C/CC/C(C)=C/C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O`	—
15	`114-15`	ABC84469.1	M15	Methylmalonyl-CoA;114-14 from: 114-14	`OC(C(C)C(O)C(C)CCC(O)CC(O)CC(O)C(C)C(C(C)C/C(C)=C/CC/C(C)=C/C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O`	{'Inactive': ['DH']}
16	`114-16`	ABC84466.1	—	114-15 from: 114-15	`OC(C(C)C(O)C(C)CCC(O)CC(O)CC(O)C(C)C(C(C)CC1(C)C(O1)CCC2(C)C(O2)C(C)CC3C(O3)C(C)CC(C)C(C)=O)=O)=O`	—
17	`114-17`	ABC84468.1;ABC84467.1	—	114-16 from: 114-16	`OC(C(C1OC(CC2OC3(C(CC(O3)(C4CCC(O4)(C5C(CC(C6C(CC(C(O)(C)O6)C)C)O5)C)C)C)C)C(C)C(O)C2)CCC1C)C)=O`	—
18	`114-18`	ABC84462.1	TE	114-17 from: 114-17	`OC(C(C1OC(CC2OC3(C(CC(O3)(C4CCC(O4)(C5C(CC(C6C(CC(C(O)(C)O6)C)C)O5)C)C)C)C)C(C)C(O)C2)CCC1C)C)=O`	—
19	`114-19`	ABC84455.1	—	114-18 from: 114-18	`OC(C(C)[C@@H](O1)[C@H](C)CCC1C[C@@H](O2)C[C@H](OC)C(C)C23[C@H](C)C[C@](C)(O3)[C@@H]4CC[C@](C)(O4)[C@@H]5C(C)C[C@@H](O5)[C@@H]6[C@H](C)CC(C)[C@](O6)(O)CC)=O`	—
20	`114`	ABC84463.1	—	114-19 from: 114-19	`OC(C(C)[C@@H](O1)[C@H](C)CCC1C[C@@H](O2)C[C@H](OC)C(C)C23[C@H](C)C[C@](C)(O3)[C@@H]4CC[C@](C)(O4)[C@@H]5C(C)C[C@@H](O5)[C@@H]6[C@H](C)CC(C)[C@](O6)(O)CO)=O`	—

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