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BGC0000110PKS

spectinabilin;orinocin;SNF4435C;SNF4435D

Producing organism
Streptomyces orinoci
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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C28H31NO6477.22 Da

Gene Cluster Map11 genes · 38,365 bp

AKSATKSATKSATKSATERKSATKSTE10 kb38.4 kb visible · 38,365 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

16 steps · 14 edges
Step 1
Start
+Chorismic acid
Step 15
Light
+110(2)/110(3)
Step 2
norE
Step 3
norG
Step 4
norF
Step 5M1
norA
+Methylmalonyl-CoA
Iterative
Step 6M2
norA_
+Methylmalonyl-CoA
Step 4M3
norA_
+Methylmalonyl-CoA
Step 7M4
norB
+Malonyl-CoA
Step 8M5
norC
+Methylmalonyl-CoA
Step 9M6
norC
+Methylmalonyl-CoA
Step 10TE
norC
Step 11
norI
Step 12
norH
Step 13
?
+110(1)
Step 14
?
+110(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1110-1Start—
Chorismic acid
O=C(O)C1=C[C@@H](OC(C(O)=O)=C)[C@H](O)C=C1—
2110-2norE—
110-1
from: 110-1
O=C(O)C1=C[C@@H](OC(C(O)=O)=C)[C@H](N)C=C1—
3110-3norG—
110-2
from: 110-2
O=C(O)C1=CC=C(N)C=C1—
4110-4norF—
110-3
from: 110-3
O=C(O)C1=CC=C([N+]([O-])=O)C=C1—
5110-5norAM1
Methylmalonyl-CoA;110-4
from: 110-4
OC(/C(C)=C/C(C)=C/C1=CC=C([N+]([O-])=O)C=C1)=O.[O]{'Iteration': ['DH', 'KR'], …
6110-6norA_M2
Methylmalonyl-CoA;110-5
from: 110-5
OC(/C(C)=C/C(C)=C/C(C)=C/C1=CC=C([N+]([O-])=O)C=C1)=O.[O]—
4110-7norA_M3
Methylmalonyl-CoA;110-6
from: 110-6
CC(/C=C(C)/C=C(C)/C=C(C)/C(O)=O)=C\C1=CC=C([N+]([O-])=O)C=C1—
7110-8norBM4
Malonyl-CoA;110-7
from: 110-7
CC(/C=C(C)/C=C(C)/C=C(C)/CCC(O)=O)=C\C1=CC=C([N+]([O-])=O)C=C1—
8110-9norCM5
Methylmalonyl-CoA;110-8
from: 110-8
CC(/C=C(C)/C=C(C)/C=C(C)/CCC(C(C)C(O)=O)=O)=C\C1=CC=C([N+]([O-])=O)C=C1—
9110-10norCM6
Methylmalonyl-CoA;110-9
from: 110-9
CC(/C=C(C)/C=C(C)/C=C(C)/CCC(C(C)C(C(C)C(O)=O)=O)=O)=C\C1=CC=C([N+]([O-])=O)C=C1—
10110-11norCTE
110-10
from: 110-10
CC(/C=C(C)/C=C(C)/C=C(C)/CCC(OC(O)=C1C)=C(C)C1=O)=C\C2=CC=C([N+]([O-])=O)C=C2—
11110-12norI—
110-11
from: 110-11
CC(/C=C(C)/C=C(C)/C=C(C)/CCC(OC(OC)=C1C)=C(C)C1=O)=C(CC=C2)\C3=C2C=C([N+]([O-])=O)C=C3—
12110(1)norH—
110-12
from: 110-12
CC(/C=C(C)/C=C(C)/C=C1COC(C(OC(OC)=C2C)=C(C)C2=O)C\1)=C\C3=CC=C([N+]([O-])=O)C=C3—
13110(2)?—
110(1)
O=C1C(C)=C(OC)OC([C@H]2C[C@]3([C@@H]([C@@]4(C)C3C(C)=CC(C)=C4)C5=CC=C([N+]([O-])=O)C=C5)CO2)=C1C—
14110(3)?—
110(1)
O=C1C(C)=C(OC)OC([C@H]2C[C@@]3([C@H]([C@]4(C)C3C(C)=CC(C)=C4)C5=CC=C([N+]([O-])=O)C=C5)CO2)=C1C—
15110(4)Light—
110(2)/110(3)
CC1=C(OC(OC)C(C)C1=O)[C@@H](C/2)OCC2=C/C3=CC=C([N+]([O-])=O)C=C3—
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