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BGC0000105PKS

nanchangmycin

Producing organism
Streptomyces nanchangensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
29
DOI
MIBiG entry
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nanchangmycin
C47H78O14866.54 Da

Gene Cluster Map33 genes · 132,544 bp

20 kb132.5 kb visible · 132,544 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

29 steps · 27 edges
Step 1Load
nanA1
+Malonyl-CoA
Step 21
Start
+Glucose-1-P
Step 2M1
nanA1
+Methylmalonyl-CoA
Inactive: KR, DH
Step 22
nanG1
Step 3M2
nanA2
+Methylmalonyl-CoA
Step 23
nanG2
Step 4M3
nanA3
+Malonyl-CoA
Step 24
nanG3
Step 5M4
nanA3
+Methylmalonyl-CoA
Step 25
nanG4
Step 6M5
nanA4
+Methylmalonyl-CoA
Inactive: KR, DH
Step 26
nanG4
Step 7M6
nanA4
+Malonyl-CoA
Inactive: DH, ER
Step 27
nanG4
Step 8M7
nanA5
+Methylmalonyl-CoA
Step 28
nanM
Step 9M8
nanA5
+Malonyl-CoA
Step 29
nanG5
Step 10M9
nanA6
+Malonyl-CoA
Inactive: KR
Step 11M10
nanA7
+Methylmalonyl-CoA
Step 12M11
nanA8
+Methylmalonyl-CoA
Step 13M12
nanA8
+Methylmalonyl-CoA
Step 14M13
nanA9;nanA10
+Methylmalonyl-CoA
Step 15
nanI
Step 16
nanO
Step 17
nanE
Step 18M14
nanA11
Step 19MCR
nanA11
Step 20
nanP
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions29 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1105-1nanA1Loading
Malonyl-CoA
OC(C)=O—
2105-2nanA1M1
105-1;Methylmalonyl-CoA
from: 105-1
OC(C(C)C(C)=O)=O{'Inactive': ['KR', 'DH']}
3105-3nanA2M2
105-2;Methylmalonyl-CoA
from: 105-2
OC(C(C)CC(C)C(C)=O)=O—
4105-4nanA3M3
105-3;Malonyl-CoA
from: 105-3
OC(/C=C/C(C)CC(C)C(C)=O)=O—
5105-5nanA3M4
105-4;Methylmalonyl-CoA
from: 105-4
OC(C(C)C/C=C/C(C)CC(C)C(C)=O)=O—
6105-6nanA4M5
105-5;Methylmalonyl-CoA
from: 105-5
CC(C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)C(O)=O{'Inactive': ['KR', 'DH']}
7105-7nanA4M6
105-6;Malonyl-CoA
from: 105-6
CC(C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)C(O)CC(O)=O{'Inactive': ['DH', 'ER']}
8105-8nanA5M7
105-7;Methylmalonyl-CoA
from: 105-7
OC(/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O—
9105-9nanA5M8
105-8;Malonyl-CoA
from: 105-8
OC(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O—
10105-10nanA6M9
105-9;Malonyl-CoA
from: 105-9
OC(CC(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O{'Inactive': ['KR']}
11105-11nanA7M10
105-10;Methylmalonyl-CoA
from: 105-10
OC(C(C)C(O)CC(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O—
12105-12nanA8M11
105-11;Methylmalonyl-CoA
from: 105-11
OC(C(C)C(O)C(C)C(O)CC(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O—
13105-13nanA8M12
105-12;Methylmalonyl-CoA
from: 105-12
OC(/C(C)=C/C(C)C(O)C(C)C(O)CC(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O—
14105-14nanA9;nanA10M13
105-13;Methylmalonyl-CoA
from: 105-13
OC(C(C)C(/C(C)=C/C(C)C(O)C(C)C(O)CC(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O)=O—
15105-15nanI—
105-14
from: 105-14
OC(C(C)C(/C(C)=C/C(C)C(O)C(C)C(O)CC(CC/C(C)=C/CC(O)C(C)C(C(C)C/C=C/C(C)CC(C)C(C)=O)=O)=O)=O)=O—
16105-16nanO—
105-14
from: 105-14
OC(C(C)C(/C(C)=C/C(C)C(O)C(C)C(O)CC(CCC1(C)C(O1)CC(O)C(C)C(C(C)CC(O2)C2C(C)CC(C)C(C)=O)=O)=O)=O)=O—
17105-17nanE—
105-15
from: 105-15
OC(C(C)C(/C(C)=C/C(C)[C@@H](O1)[C@H](C)C(O)CC12CC[C@](C)(O2)[C@@H](O3)CC(O)[C@@H](C)[C@@]3(O4)[C@H](C)C[C@H]4C(O5)C(C)C[C@@H](C)[C@@]5(O)C)=O)=O—
18105-18nanA11M14
105-16
from: 105-16
CC(C(/C(C)=C/C(C)[C@@H](O1)[C@H](C)C(O)CC12CC[C@](C)(O2)[C@@H](O3)CC(O)[C@@H](C)[C@@]3(O4)[C@H](C)C[C@H]4C(O5)C(C)C[C@@H](C)[C@@]5(O)C)=O)CC(C)C(O)=O—
19105-19nanA11MCR
105-17
from: 105-17
CC(C(/C(C)=C/C(C)[C@@H](O1)[C@H](C)C(O)CC12CC[C@](C)(O2)[C@@H](O3)CC(O)[C@@H](C)[C@@]3(O4)[C@H](C)C[C@H]4C(O5)C(C)C[C@@H](C)[C@@]5(O)C)=O)CC(C)C(O)=O—
20105-20nanP—
105-18
from: 105-18
CC(C(/C(C)=C/C(C)[C@@H](O1)[C@H](C)C(O)CC12CC[C@](C)(O2)[C@@H](O3)CC(O)[C@@H](C)[C@@]3(O4)[C@H](C)C[C@H]4C(O5)C(C)C[C@@H](C)[C@@]5(O)CO)=O)CC(C)C(O)=O—
21105-21Start—
Glucose-1-P
O[C@H]1[C@H](O)[C@@H](O)[C@@H](OP([O-])([O-])=O)O[C@@H]1CO—
22105-22nanG1—
105-21
from: 105-21
O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[R])O[C@@H]1CO—
23105-23nanG2—
105-22
from: 105-22
C[C@H]1O[C@H](O[R])[C@H](O)[C@@H](O)C1=O—
24105-24nanG3—
105-23
from: 105-23
C[C@H]1O[C@H](O[R])C[C@@H](O)C1=O—
25105-25nanG4—
105-24
from: 105-24
C[C@H]1O[C@H](O[R])CCC1=O—
26105-26nanG4—
105-25
from: 105-25
[R]O[C@@H]1CCC([C@H](C)O1)=O—
27105-27nanG4—
105-26
from: 105-26
[R]O[C@@H]1CC[C@H](O)[C@H](C)O1—
28105-28nanM—
105-27
from: 105-27
[R]O[C@@H]1CC[C@H](OC)[C@H](C)O1—
29105nanG5—
105-28
from: 105-28
CC(C(/C(C)=C/C(C)[C@@H](O1)[C@H](C)C(O)CC12CC[C@](C)(O2)[C@@H](O3)CC(OC4CCC(OC)C(C)O4)[C@@H](C)[C@@]3(O5)[C@H](C)C[C@H]5C(O6)C(C)C[C@@H](C)[C@@]6(O)CO)=O)CC(C)C(O)=O—
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