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BGC0000102PKS

mycinamicin II

Producing organism
Micromonospora griseorubida
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
25
DOI
MIBiG entry
View on MIBiG ↗
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mycinamicin II
C37H61NO13727.41 Da

Gene Cluster Map21 genes · 58,343 bp

KSATKSATKSATKSATKSATKSATERKSATKSAT10 kb58.3 kb visible · 58,343 bp total
Biosynthetic (core)
Biosynthetic (additional)
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

25 steps · 24 edges
Step 1Load
mycAI
+Methylmalonyl-CoA
Step 9
Start
+Glucose-1-P
Step 2M1
mycAI
+Methylmalonyl-CoA
Step 10
mydA
Step 3M2
mycAI
+Malonyl-CoA
Step 11
mydB
Step 4M3
mycAII
+Malonyl-CoA
Step 12
mydC
Step 17
mydH
Step 5M4
mycAIII
+Methylmalonyl-CoA
Inactive: KR
Step 13
mydD
Step 18
mydH
Step 6M5
mycAIII
+Methylmalonyl-CoA
Step 14
mydE
Step 7M6
mycAIV
+Methylmalonyl-CoA
Step 15
mydF
Step 8M7
mycAV
+Malonyl-CoA
Step 16
mydG
Step 19TE
mycAV
Step 20
mycB
Step 21
mycCI;mycCII
Step 22
mycD
Step 23
mycE
Step 24
mydF
Step 25
mydG
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions25 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1102-1mycAILoading
Methylmalonyl-CoA
OC(CC)=O—
2102-2mycAIM1
102-1;Methylmalonyl-CoA
from: 102-1
OC([C@H](C)CCC)=O—
3102-3mycAIM2
102-2;Malonyl-CoA
from: 102-2
OC(/C=C/[C@H](C)CCC)=O—
4102-4mycAIIM3
102-3;Malonyl-CoA
from: 102-3
OC(/C=C/C=C/[C@H](C)CCC)=O—
5102-5mycAIIIM4
102-4;Methylmalonyl-CoA
from: 102-4
OC(C(C)C(/C=C/C=C/[C@H](C)CCC)=O)=O{'Inactive':['KR']}
6102-6mycAIIIM5
102-5;Methylmalonyl-CoA
from: 102-5
OC(C(C)C[C@@H](C)C(/C=C/C=C/[C@H](C)CCC)=O)=O—
7102-7mycAIVM6
102-6;Methylmalonyl-CoA
from: 102-6
OC(C(C)[C@@H](O)[C@@H](C)C[C@@H](C)C(/C=C/C=C/[C@H](C)CCC)=O)=O—
8102-8mycAVM7
102-7;Malonyl-CoA
from: 102-7
OC(/C=C/[C@H](C)[C@@H](O)[C@@H](C)C[C@@H](C)C(/C=C/C=C/[C@H](C)CCC)=O)=O—
9102-9Start—
Glucose-1-P
O[C@@H]1[C@@H](CO)OC(OP([O-])([O-])=O)[C@H](O)[C@H]1O—
10102-10mydA—
102-9
from: 102-9
O[C@@H]1[C@@H](CO)OC(O[R])[C@H](O)[C@H]1O—
11102-11mydB—
102-10
from: 102-10
C[C@@H]1C([C@H](O)[C@@H](O)C(O[R])O1)=O—
12102-12mydC—
102-11
from: 102-11
C[C@@H]1[C@@H](O)C([C@@H](O)C(O[R])O1)=O—
13102-13mydD—
102-12
from: 102-12
C[C@@H]1[C@@H](O)[C@H](N)[C@@H](O)C(O[R])O1—
14102-14mydE—
102-13
from: 102-13
C[C@@H]1C=C(N)[C@@H](O)C(O[R])O1—
15102-15mydF—
102-14
from: 102-14
C[C@@H]1C[C@H](N)[C@@H](O)C(O[R])O1—
16102-16mydG—
102-15
from: 102-15
C[C@@H]1C[C@H](N(C)C)[C@@H](O)C(O[R])O1—
17102-17mydH—
102-11
from: 102-11
C[C@@H]1C([C@@H](O)[C@@H](O)C(O[R])O1)=O—
18102-18mydH—
102-17
from: 102-17
C[C@@H]1C(O)[C@@H](O)[C@@H](O)C(O[R])O1—
19102-19mycAVTE
102-8
from: 102-8
C[C@@H](/C=C/C(O[C@H](CC)[C@H](/C=C/C=C/1)C)=O)[C@@H](O)[C@@H](C)C[C@@H](C)C1=O—
20102-20mycB—
102-19;102-16
from: 102-19, 102-16
C[C@@H](/C=C/C(O[C@H](CC)[C@H](/C=C/C=C/1)C)=O)[C@@H](O[C@H]2[C@@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@@H](C)C[C@@H](C)C1=O—
21102-21mycCI;mycCII—
102-20
from: 102-20
C[C@@H](/C=C/C(O[C@H](CC)[C@H](/C=C/C=C/1)CO)=O)[C@@H](O[C@H]2[C@@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@@H](C)C[C@@H](C)C1=O—
22102-22mycD—
102-21
from: 102-21
C[C@@H](/C=C/C(O[C@H](CC)[C@H](/C=C/C=C/1)CO[C@H]2[C@H](O)[C@H](O)[C@H](O)[C@@H](C)O2)=O)[C@@H](O[C@H]3[C@@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@@H](C)C[C@@H](C)C1=O—
23102-23mycE—
102-22
from: 102-22
C[C@@H](/C=C/C(O[C@H](CC)[C@H](/C=C/C=C/1)CO[C@H]2[C@H](OC)[C@H](O)[C@H](O)[C@@H](C)O2)=O)[C@@H](O[C@H]3[C@@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@@H](C)C[C@@H](C)C1=O—
24102-24mydF—
102-23
from: 102-23
C[C@@H](/C=C/C(O[C@H](CC)[C@H]([C@@H](O1)[C@H]1/C=C/2)CO[C@H]3[C@H](OC)[C@H](O)[C@H](O)[C@@H](C)O3)=O)[C@@H](O[C@H]4[C@@H](O)[C@@H](N(C)C)C[C@@H](C)O4)[C@@H](C)C[C@@H](C)C2=O—
25102mydG—
102-24
from: 102-24
C[C@@H](/C=C/C(O[C@H](CC)[C@H]([C@@H](O1)[C@H]1/C=C/2)CO[C@H]3[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O3)=O)[C@@H](O[C@H]4[C@@H](O)[C@@H](N(C)C)C[C@@H](C)O4)[C@@H](C)C[C@@H](C)C2=O—
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