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BGC0000100PKS

Monensin

Producing organism
Streptomyces virginiae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
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monensin
C36H62O11670.43 Da

Gene Cluster Map34 genes · 103,450 bp

20 kb103.4 kb visible · 103,450 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
monAI
+Malonyl-CoA
Step 2M1
monAI
+Methylmalonyl-CoA
Step 3M2
monAII
+Methylmalonyl-CoA
Step 4M3
monAIII
+Malonyl-CoA
Step 5M4
monAIII
+Methylmalonyl-CoA
Step 6M5
monAIV
+Ethylmalonyl-CoA
Step 7M6
monAIV
+Malonyl-CoA
Step 8M7
monAV
+Methylmalonyl-CoA
Step 9M8
monAVI
+Malonyl-CoA
Step 10M9
monAVII
+Malonyl-CoA
Step 11M10
monAVII
+Methylmalonyl-CoA
Step 12M11
monAVIII
+Methylmalonyl-CoA
Step 13M12
monAVIII
+Methylmalonyl-CoA
Step 14
monC1
Step 15
monBI;monBII
Step 16
monD, monE, monCII
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1100-1monAILoading
Malonyl-CoA
O=C(O)C—
2100-2monAIM1
100-1;Methylmalonyl-CoA
from: 100-1
O=C([C@H](C)C(O)=O)C—
3100-3monAIIM2
100-2;Methylmalonyl-CoA
from: 100-2
O=C([C@H](C)C[C@H](C)C(O)=O)C—
4100-4monAIIIM3
100-3;Malonyl-CoA
from: 100-3
O=C([C@H](C)C[C@H](C)/C=C/C(O)=O)C—
5100-5monAIIIM4
100-4;Methylmalonyl-CoA
from: 100-4
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)C(O)=O)C—
6100-6monAIVM5
100-5;Ethylmalonyl-CoA
from: 100-5
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/C(O)=O)C—
7100-7monAIVM6
100-6;Malonyl-CoA
from: 100-6
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CCC(O)=O)C—
8100-8monAVM7
100-7;Methylmalonyl-CoA
from: 100-7
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/C(O)=O)C—
9100-9monAVIM8
100-8;Malonyl-CoA
from: 100-8
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(O)=O)C—
10100-10monAVIIM9
100-9;Malonyl-CoA
from: 100-9
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(CC(O)=O)=O)C—
11100-11monAVIIM10
100-10;Methylmalonyl-CoA
from: 100-10
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(C[C@H](O)[C@@H](C)C(O)=O)=O)C—
12100-12monAVIIIM11
100-11;Methylmalonyl-CoA
from: 100-11
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(C[C@H](O)[C@@H](C)[C@H](O)[C@H](C(O)=O)C)=O)C—
13100-13monAVIIIM12
100-12;Methylmalonyl-CoA
from: 100-12
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(CC)/CC/C=C(C)/CCC(C[C@H](O)[C@@H](C)[C@H](O)[C@H]([C@@H](O)[C@@H](C(O)=O)C)C)=O)C—
14100-14monC1—
100-13
from: 100-13
O=C([C@H](C)C[C@H](C)[C@H]1[C@@H](O1)C[C@H](C)[C@@H]2[C@](CC)(O2)CC[C@@H]3[C@](C)(O3)CCC(C[C@H](O)[C@@H](C)[C@H](O)[C@H]([C@@H](O)[C@@H](C(O)=O)C)C)=O)C—
15100-15monBI;monBII—
100-14
from: 100-14
C[C@@H]([C@@H](O)[C@@H](C(O)=O)C)[C@H]1O[C@]2(O[C@@]([C@@H]3O[C@@]([C@@H]4O[C@@H]([C@H]5O[C@@](O)(C)[C@H](C)C[C@@H]5C)C[C@@H]4C)(CC)CC3)(C)CC2)C[C@H](O)[C@H]1C—
16100monD, monE, monCII—
100-15
from: 100-15
C[C@@H]([C@@H](OC)[C@@H](C(O)=O)C)[C@H]1O[C@]2(O[C@@]([C@@H]3O[C@@]([C@@H]4O[C@@H]([C@H]5O[C@@](O)(CO)[C@H](C)C[C@@H]5C)C[C@@H]4C)(CC)CC3)(C)CC2)C[C@H](O)[C@H]1C—
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