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BGC0000097PKS

ML-449

Producing organism
Streptomyces sp. MP39-85
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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ML-449
C29H39NO3449.29 Da

Gene Cluster Map24 genes · 89,357 bp

KSKSKSKSKSKS20 kb89.4 kb visible · 89,357 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
mlaA1
+Methylmalonyl-CoA
Step 2M1
mlaA1
+Malonyl-CoA
Step 3M2
mlaA1
+Malonyl-CoA
Step 4M3
mlaA1
+Malonyl-CoA
Step 5M4
mlaA2;mlaC; mlaI;mlaL;m…
+Malonyl-CoA
Inactive: DH
Step 6
mlaQ
Step 7
mlaJ
Step 8Load
mlaK; mlaB
Step 9M1
mlaB
+Malonyl-CoA
Step 10M2
mlaB
+Methylmalonyl-CoA
Step 11M3
mlaD
+Malonyl-CoA
Step 12M4
mlaD
+Malonyl-CoA
Step 14M6
mlaF
+Methylmalonyl-CoA
Step 13M5
mlaE
+Malonyl-CoA
Inactive: DH
Step 15M7
mlaF
+Malonyl-CoA
Step 16M8
mlaG
+Malonyl-CoA
Step 17TE
mlaG
Step 18
mlaO
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
197-1mlaA1Loading
Methylmalonyl-CoA
O=C(CC)O—
297-2mlaA1M1
97-1;Malonyl-CoA
from: 97-1
CC/C=C/C(O)=O—
397-3mlaA1M2
97-2;Malonyl-CoA
from: 97-2
CC/C=C/C=C/C(O)=O—
497-4mlaA1M3
97-3;Malonyl-CoA
from: 97-3
CC/C=C/C=C/C=C/C(O)=O—
597-5mlaA2;mlaC; mlaI;mlaL;mlaSM4
97-4;Malonyl-CoA
from: 97-4
CCC/C=C/C=C/CC(N)CC(O)=O{'Inactive': ['DH']}
697-6mlaQ—
97-5
from: 97-5
CCC/C=C/C=C/CC(N)CC(O)=O—
797-7mlaJ—
97-6
from: 97-6
CCC/C=C/C=C/CC(N)CC([R])=O—
897-8mlaK; mlaBLoading
97-7
from: 97-7
CCC/C=C/C=C/CC(N)CC(O)=O—
997-9mlaBM1
97-8;Malonyl-CoA
from: 97-8
CCC/C=C/C=C/CC(N)C/C=C/C(O)=O—
1097-10mlaBM2
97-9;Methylmalonyl-CoA
from: 97-9
CCC/C=C/C=C/CC(N)C/C=C/C=C(C(O)=O)\C—
1197-11mlaDM3
97-10;Malonyl-CoA
from: 97-10
CCC/C=C/C=C/CC(N)C/C=C/C=C(/C=C/C(O)=O)C—
1297-12mlaDM4
97-11;Malonyl-CoA
from: 97-11
CCC/C=C/C=C/CC(N)C/C=C/C=C(/C=C/C=C/C(O)=O)C—
1397-13mlaEM5
97-12;Malonyl-CoA
from: 97-12
CCC/C=C/C=C/CC(N)C/C=C/C=C(/C=C/C=C/C(O)CC(O)=O)C{'Inactive': ['DH']}
1497-14mlaFM6
97-11;Methylmalonyl-CoA
from: 97-11
CCC/C=C/C=C/CC(N)C/C=C/C=C(/C=C/C=C/C(O)C/C=C(C(O)=O)\C)C—
1597-15mlaFM7
97-14;Malonyl-CoA
from: 97-14
CCC/C=C/C=C/CC(N)C/C=C/C=C(/C=C/C=C/C(O)C/C=C(/C=C/C(O)=O)C)C—
1697-16mlaGM8
97-15;Malonyl-CoA
from: 97-15
CCC/C=C/C=C/CC(N)C/C=C/C=C(/C=C/C=C/C(O)C/C=C(/C=C/C=C/C(O)=O)C)C—
1797-17mlaGTE
97-16
from: 97-16
O=C1NC(C/C=C/C=C/CCC)C/C=C/C=C(C)/C=C/C=C\C(O)C/C=C(C)\C=C\C=C\1—
1897mlaO—
97-17
from: 97-17
O=C1NC(C/C=C/C=C/CCC)C/C=C/C=C(C)/C=C/C=C\C(O)C(O)/C=C(C)\C=C\C=C\1—
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