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BGC0000096PKS

Midecamycin

Producing organism
Streptomyces mycarofaciens
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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midecamycin
C41H67NO15813.45 Da

Gene Cluster Map43 genes · 84,428 bp

KSKSKSKSKSKSKS20 kb84.4 kb visible · 84,428 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
DHtDehydratase (DHt)

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
ctg1_orf27
+Malonyl-CoA
Step 10
Start
+mycaminose
Step 14
Start
+mycarose
Step 2M1
ctg1_orf27
+Malonyl-CoA
Step 3M2
ctg1_orf27
+Malonyl-CoA
Step 4M3
ctg1_orf28
+Malonyl-CoA
Step 5M4
ctg1_orf29
+Methylmalonyl-CoA
Inactive: KR
Step 6M5
ctg1_orf29
+Ethylmalonyl-CoA
Step 7M6
ctg1_orf30
+Methoxymalonyl-ACP
Step 8M7
ctg1_orf31
+Malonyl-CoA
Step 9TE
ctg1_orf31
Step 11
ctg1_orf33
Step 12
?
Step 13
?
Step 15
?
Step 16
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
196-1ctg1_orf27Loading
Malonyl-CoA
O=C(C)O—
296-2ctg1_orf27M1
96-1;Malonyl-CoA
from: 96-1
C[C@@H](O)CC(O)=O—
396-3ctg1_orf27M2
96-2;Malonyl-CoA
from: 96-2
C[C@@H](O)C/C=C/C(O)=O—
496-4ctg1_orf28M3
96-3;Malonyl-CoA
from: 96-3
C[C@@H](O)C/C=C/C=C/C(O)=O—
596-5ctg1_orf29M4
96-4;Methylmalonyl-CoA
from: 96-4
C[C@@H](O)C/C=C/C=C/C([C@@H](C(O)=O)C)=O{'Inactive': ['KR']}
696-6ctg1_orf29M5
96-5;Ethylmalonyl-CoA
from: 96-5
C[C@@H](O)C/C=C/C=C/C([C@@H](C[C@@H](C(O)=O)CC)C)=O—
796-7ctg1_orf30M6
96-6;Methoxymalonyl-ACP
from: 96-6
C[C@@H](O)C/C=C/C=C/C([C@@H](C[C@@H]([C@H](O)[C@H](C(O)=O)OC)CC)C)=O—
896-8ctg1_orf31M7
96-7;Malonyl-CoA
from: 96-7
C[C@@H](O)C/C=C/C=C/C([C@@H](C[C@@H]([C@H](O)[C@H]([C@H](O)CC(O)=O)OC)CC)C)=O—
996-9ctg1_orf31TE
96-8
from: 96-8
O=C(/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC)[C@H](O)[C@@H](OC)[C@H](O)CC1=O—
1096-10Start—
mycaminose
O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O)C(C)O1—
1196-11ctg1_orf33—
96-9;96-10
from: 96-9, 96-10
O[C@@H](/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
1296-12?—
96-11
from: 96-11
O[C@@H](/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CCO)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
1396-13?—
96-12
from: 96-12
O[C@@H](/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
1496-14Start—
mycarose
O[C@@H]1O[C@@H](C)[C@H](O)[C@@](O)(C)C1—
1596-15?—
96-13;96-14
from: 96-13, 96-14
O[C@@H](/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@](O)(C)C3)C(C)O2)[C@@H](OC)[C@H](O)CC1=O—
1696?—
96-15
from: 96-15
O[C@@H](/C=C/C=C/C[C@@H](C)O1)[C@H](C)C[C@H](CC=O)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC)=O)[C@@](O)(C)C3)C(C)O2)[C@@H](OC)[C@H](OC(CC)=O)CC1=O—
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