NPdia
← Back to Repository
BGC0000094PKS

Methymycin

Producing organism
Streptomyces venezuelae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
Loading…
methymycin
C25H43NO7469.30 Da

Gene Cluster Map7 genes · 37,948 bp

KSATKSATKSATKRKSATKRKSATERKRKSATKSATTETE10 kb37.9 kb visible · 37,948 bp total
Biosynthetic (core)
Biosynthetic (additional)
Resistance
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
BN2537_RS40935
+Methylmalonyl-CoA
Step 8
Start
+D-glucose-1-P
Step 2M1
BN2537_RS14895
+Methylmalonyl-CoA
Inactive: DH
Step 9
BN2537_RS14950
Step 3M2
BN2537_RS14895
+Malonyl-CoA
Step 10
BN2537_RS14945
Step 4M3
BN2537_RS14900
+Methylmalonyl-CoA
Inactive: KR
Step 11
BN2537_RS40940
Step 5M4
BN2537_RS14900
+Methylmalonyl-CoA
Step 12
BN2537_RS40940
Step 6M5
BN2537_RS14905
+Methylmalonyl-CoA
Step 13
BN2537_RS14940
Step 7
BN2537_RS14910
Step 14
BN2537_RS14930
Step 15
BN2537_RS14925
Step 16
BN2537_RS14965
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
194-1BN2537_RS40935Loading
Methylmalonyl-CoA
O=C(CC)O—
294-2BN2537_RS14895M1
94-1;Methylmalonyl-CoA
from: 94-1
O[C@H](CC)[C@@H](C(O)=O)C{'Inactive': ['DH']]}
394-3BN2537_RS14895M2
94-2;Malonyl-CoA
from: 94-2
O[C@H](CC)[C@@H](/C=C/C(O)=O)C—
494-4BN2537_RS14900M3
94-3;Methylmalonyl-CoA
from: 94-3
O[C@H](CC)[C@@H](/C=C/C([C@@H](C(O)=O)C)=O)C{'Inactive': ['KR']}
594-5BN2537_RS14900M4
94-4;Methylmalonyl-CoA
from: 94-4
O[C@H](CC)[C@@H](/C=C/C([C@@H](C[C@@H](C(O)=O)C)C)=O)C—
694-6BN2537_RS14905M5
94-5;Methylmalonyl-CoA
from: 94-5
O[C@H](CC)[C@@H](/C=C/C([C@@H](C[C@@H]([C@H](O)[C@H](C(O)=O)C)C)C)=O)C—
794-7BN2537_RS14910—
94-6
from: 94-6
O=C1O[C@H](CC)[C@H](C)/C=C/C([C@H](C)C[C@H](C)[C@H](O)[C@H]1C)=O—
894-8Start—
D-glucose-1-P
O[C@H]1[C@H](O)[C@@H](O)[C@@H](OP([O-])([O-])=O)O[C@@H]1CO—
994-9BN2537_RS14950—
94-8
from: 94-8
O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[R])O[C@@H]1CO—
1094-10BN2537_RS14945—
94-9
from: 94-9
C[C@H]1O[C@H](O[R])[C@H](O)[C@@H](O)C1=O—
1194-11BN2537_RS40940—
94-10
from: 94-10
C[C@H]1O[C@H](O[R])[C@H](O)[C@@H](O)[C@@H]1N—
1294-12BN2537_RS40940—
94-11
from: 94-11
C[C@H]1O[C@H](O[R])[C@H](O)C([C@@H]1N)=O—
1394-13BN2537_RS14940—
94-12
from: 94-12
C[C@H]1O[C@H](O[R])[C@H](O)[C@@H](N)C1—
1494-14BN2537_RS14930—
94-13
from: 94-13
C[C@H]1O[C@H](O[R])[C@H](O)[C@@H](N(C)C)C1—
1594-15BN2537_RS14925—
94-7;94-14
from: 94-7, 94-14
O=C1O[C@H](CC)[C@H](C)/C=C/C([C@H](C)C[C@H](C)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@H]1C)=O—
1694BN2537_RS14965—
94-15
from: 94-15
O=C1O[C@H](C([H])C)[C@@](C)(O)/C=C/C([C@H](C)C[C@H](C)[C@H](O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@H]1C)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture