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BGC0000093PKS

Meilingmycin;Meilingmycin A;Meilingmycin B;Meilingmycin E;Meilingmycin D;Meilingmycin C

Producing organism
Streptomyces nanchangensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
22
DOI
MIBiG entry
View on MIBiG ↗
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meilingmycin
C36H52O8612.37 Da

Gene Cluster Map92 genes · 185,250 bp

50 kb185.2 kb visible · 185,250 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

22 steps · 21 edges
Step 1Load
meiA1
+Acetyl-CoA/Propio…
Step 2M1
meiA1
+Methylmalonyl-CoA
Step 3M2
meiA1;meiC
+Malonyl-CoA
Step 4M3
meiA2
+Malonyl-CoA
Step 5M4
meiA2
+Malonyl-CoA
Step 6M5
meiA2
+Malonyl-CoA
Step 7M6
meiA2
+Methylmalonyl-CoA
Step 8M7
meiA3
+Methylmalonyl-CoA
Step 9M8
meiA3
+Malonyl-CoA
Step 10M9
meiA3
+Methylmalonyl-CoA
Step 11M10
meiA4
+Malonyl-CoA
Inactive: KR
Step 12M11
meiA4
+Methylmalonyl-CoA
Inactive: KR
Step 13M12
meiA4
+Malonyl-CoA
Step 14TE
meiA4
Step 15
meiF
Step 16
meiE
Step 20
meiD
Step 17
?
Step 18
?
Step 19
?
Step 21
meiE
Step 22
meiE
+93(3)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
193-1meiA1Loading
Acetyl-CoA/Propionyl-CoA
O=C(C[R])O—
293-2meiA1M1
93-1;Methylmalonyl-CoA
from: 93-1
OC(C[R])C(C(O)=O)C—
393-3meiA1;meiCM2
93-2;Malonyl-CoA
from: 93-2
OC(C[R])C(CCC(O)=O)C—
493-4meiA2M3
93-3;Malonyl-CoA
from: 93-3
OC(C[R])C(CCC(CC(O)=O)=O)C—
593-5meiA2M4
93-4;Malonyl-CoA
from: 93-4
OC(C[R])C(CCC(CC(O)CC(O)=O)=O)C—
693-6meiA2M5
93-5;Malonyl-CoA
from: 93-5
OC(C[R])C(CCC(CC(O)CC(O)CC(O)=O)=O)C—
793-7meiA2M6
93-6;Methylmalonyl-CoA
from: 93-6
OC(C[R])C(CCC(CC(O)CC(O)C/C=C(C(O)=O)\C)=O)C—
893-8meiA3M7
93-7;Methylmalonyl-CoA
from: 93-7
OC(C[R])C(CCC(CC(O)CC(O)C/C=C(CC(C(O)=O)C)\C)=O)C—
993-9meiA3M8
93-8;Malonyl-CoA
from: 93-8
OC(C[R])C(CCC(CC(O)CC(O)C/C=C(CC(/C=C/C(O)=O)C)\C)=O)C—
1093-10meiA3M9
93-9;Methylmalonyl-CoA
from: 93-9
OC(C[R])C(CCC(CC(O)CC(O)C/C=C(CC(/C=C/C=C(C(O)=O)\C)C)\C)=O)C—
1193-11meiA4M10
93-10;Malonyl-CoA
from: 93-10
OC(C[R])C(CCC(CC(O)CC(O)C/C=C(CC(/C=C/C=C(C(CC(O)=O)=O)\C)C)\C)=O)C{'Inactive': ['KR']}
1293-12meiA4M11
93-11;Methylmalonyl-CoA
from: 93-11
OC(C[R])C(CCC(CC(O)CC(O)C/C=C(CC(/C=C/C=C(C(CC(C(C(O)=O)C)=O)=O)\C)C)\C)=O)C{'Inactive': ['KR']}
1393-13meiA4M12
93-12;Malonyl-CoA
from: 93-12
OC(C[R])C(CCC(CC(O)CC(O)C/C=C(CC(/C=C/C=C(C(CC(C(/C=C/C(O)=O)C)=O)=O)\C)C)\C)=O)C—
1493-14meiA4TE
93-13
from: 93-13
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C(C)/C(C3)(O)C1C=C(C)C3=O)OC42CCC(C)C(C[R])O4—
1593-15meiF—
93-14
from: 93-14
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C(C)/C3(O)C1C=C(C)C(O)C3)OC42CCC(C)C(C[R])O4—
1693-16meiE—
93-15
from: 93-15
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C3C4(O)C1C=C(C)C(O)C4OC/3)OC52CCC(C)C(C[R])O5—
1793(1)?—
93-16
from: 93-16
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C3C4(O)C1C=C(COC(/C=C(C)\C)=O)C(O)C4OC/3)OC52CCC(C)C(C)O5—
1893(2)?—
93-16
from: 93-16
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C3C4(O)C1C=C(COC(/C=C(CC)\C)=O)C(O)C4OC/3)OC52CCC(C)C(C)O5—
1993(3)?—
93-16
from: 93-16
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C3C4(O)C1C=C(COC(/C=C(C)\C)=O)C(O)C4OC/3)OC52CCC(C)C(CC)O5—
2093-17meiD—
93-15
from: 93-15
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C(C)/C3(O)C1C=C(C)C(OC)C3)OC42CCC(C)C(C)O4—
2193(3)meiE—
93-17
from: 93-17
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C(CO)/C3(O)C1C=C(C)C(OC)C3)OC42CCC(C)C(C)O4—
2293(4)meiE—
93(3)
O=C1OC(C2)CC(C/C=C(C)/CC(C)/C=C/C=C(CO)/C3(O)C1C=C(C)C(OC)C3O)OC42CCC(C)C(C)O4—
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