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BGC0000092PKS

Megalomicin A;Megalomicin B;Megalomicin C1;Megalomicin C2

Producing organism
Micromonospora megalomicea subsp. nigra
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
36
DOI
MIBiG entry
View on MIBiG ↗
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C44H80N2O15876.56 Da

Gene Cluster Map19 genes · 47,981 bp

ATKSATKSATKSATKSATERKSATKSAT10 kb48.0 kb visible · 47,981 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase V
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

36 steps · 37 edges
Step 1Load
megAI
+Propionyl-CoA
Step 10
Start
+D-glucose-1-OPO3
Step 2M1
megAI
+Methylmalonyl-CoA
Step 11
?
Step 3M2
megAI
+Methylmalonyl-CoA
Step 12
?
Step 4M3
megAII
+Methylmalonyl-CoA
Step 13
megT
Step 14
megT
Step 26
megCII
Step 5M4
megAII
+Methylmalonyl-CoA
Step 15
megDIV
Step 16
megDIV
Step 27
?
Step 6M5
megAIII
+Methylmalonyl-CoA
Step 17
megDVII
Step 28
?
Step 7M6
megAIII
+Methylmalonyl-CoA
Step 18
megDV
Step 19
megDVII
Step 29
?
Step 8TE
megAIII
Step 20
megDII
Step 9
megF
Step 21
megDIII
Step 22
megBII
Step 23
?
Step 24
?
Step 25
megBIV
Step 30
megBV
Step 31
megCIII
Step 32
?
Step 33
megDI
Step 34
megY
+92(1)
Step 35
megY
+92(1)
Step 36
megY
+92(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions36 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
192-1megAILoading
Propionyl-CoA
CCC(O)=O—
292-2megAIM1
92-1;Methylmalonyl-CoA
from: 92-1
C[C@@H]([C@H](O)CC)C(O)=O—
392-3megAIM2
92-2;Methylmalonyl-CoA
from: 92-2
C[C@@H]([C@H](O)CC)C(C(C)C(O)=O)=O—
492-4megAIIM3
92-3;Methylmalonyl-CoA
from: 92-3
C[C@@H]([C@H](O)CC)C(C(C)C([C@H](C)C(O)=O)=O)=O—
592-5megAIIM4
92-4;Methylmalonyl-CoA
from: 92-4
C[C@@H]([C@H](O)CC)C(C(C)C([C@H](C)C[C@H](C)C(O)=O)=O)=O—
692-6megAIIIM5
92-5;Methylmalonyl-CoA
from: 92-5
C[C@@H]([C@H](O)CC)C(C(C)C([C@H](C)C[C@H](C)C(O)C(C)C(O)=O)=O)=O—
792-7megAIIIM6
92-6;Methylmalonyl-CoA
from: 92-6
C[C@@H]([C@H](O)CC)C(C(C)C([C@H](C)C[C@H](C)C(O)C(C)C(O)C(C)C(O)=O)=O)=O—
892-8megAIIITE
92-7
from: 92-7
O[C@@H]1[C@@H](C)[C@H](O)[C@@H](C)C(O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@@H]1C)=O)=O—
992-9megF—
92-8
from: 92-8
CC(C(C(C)C(O)C(C)C(CC)O1)=O)CC(C)(O)C(O)C(C)C(O)C(C)C1=O—
1092-10Start—
D-glucose-1-OPO3
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O—
1192-11?—
92-10
from: 92-10
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O—
1292-12?—
92-11
from: 92-11
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1=O—
1392-13megT—
92-12
from: 92-12
C[C@H]1O[C@H]([R])C=C(O)C1=O—
1492-14megT—
92-12
from: 92-12
C[C@H](C1=O)O[C@H]([R])CC1=O—
1592-15megDIV—
92-13
from: 92-13
[R][C@@H](O[C@@H](C)C1=O)CC1=O—
1692-16megDIV—
92-14
from: 92-14
[R][C@@H](O[C@H]1C)C=C(O)C1=O—
1792-17megDVII—
92-16
from: 92-16
[R][C@@H](O[C@H]1C)C[C@H](O)C1=O—
1892-18megDV—
92-15
from: 92-15
[R][C@@H](O[C@@H](C)[C@H]1O)CC1=O—
1992-18megDVII—
92-17
from: 92-17
[R][C@@H](O[C@@H](C)[C@H]1O)CC1=O—
2092-19megDII—
92-18
from: 92-18
[R][C@@H]1C[C@H](N)[C@H](O)[C@H](C)O1—
2192-20megDIII—
92-19
from: 92-19
[R][C@@H]1C[C@H](N(C)C)[C@H](O)[C@H](C)O1—
2292-21megBII—
92-13/92-14
from: 92-13/92-14
C[C@H]1O[C@H]([R])C[C@H](O)C1=O—
2392-22?—
92-21
from: 92-21
[R][C@@H](O[C@H]1C)C[C@H](O)C1=O—
2492-23?—
92-22
from: 92-22
[R][C@@H](O[C@H]1C)C[C@@](O)(C)C1=O—
2592-24megBIV—
92-23
from: 92-23
[R][C@@H]1C[C@H](O)[C@H](O)[C@H](C)O1—
2692-25megCII—
92-12
from: 92-12
C[C@H](C1O)O[C@H]([R])[C@H](O)C1=O—
2792-26?—
92-25
from: 92-25
C[C@H](C1)O[C@H]([R])[C@H](O)C1=O—
2892-27?—
92-26
from: 92-26
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](N)C1—
2992-28?—
92-27
from: 92-27
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](N(C)C)C1—
3092-29megBV—
92-9;92-24
from: 92-9, 92-24
CC(C(C(C)C(O)C(C)C(CC)O1)=O)CC(C)(O)C(O)C(C)C(O[C@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)C(C)C1=O—
3192-30megCIII—
92-28;92-29
from: 92-28, 92-29
CC(C(C(C)C(O)C(C)C(CC)O1)=O)CC(C)(O)C(O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)C(C)C(O[C@H]3O[C@@H](C)[C@H](O)[C@](C)(O)C3)C(C)C1=O—
3292-31?—
92-30
from: 92-30
CC(C(C(C)C(O)C(C)(O)C(CC)O1)=O)CC(C)(O)C(O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)C(C)C(O[C@H]3O[C@@H](C)[C@H](O)[C@](C)(O)C3)C(C)C1=O—
3392(1)megDI—
92-20;92-31
from: 92-20, 92-31
CC(C(C(C)C(O)C(C)(O)C(CC)O1)=O)CC(C)(OC2C[C@@H](N(C)C)[C@H](O)[C@@H](C)O2)C(O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)C(C)C(O[C@H]4O[C@@H](C)[C@H](O)[C@](C)(O)C4)C(C)C1=O—
3492(2)megY—
92(1)
CC(C(C(C)C(O)C(C)(O)C(CC)O1)=O)CC(C)(OC2C[C@@H](N(C)C)[C@H](O)[C@@H](C)O2)C(O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)C(C)C(O[C@H]4O[C@@H](C)[C@H](OC(C)=O)[C@](C)(O)C4)C(C)C1=O—
3592(3)megY—
92(1)
CC(C(C(C)C(O)C(C)(O)C(CC)O1)=O)CC(C)(OC2C[C@@H](N(C)C)[C@H](O)[C@@H](C)O2)C(O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)C(C)C(O[C@@H]4O[C@@H](C)[C@H](OC(C)=O)[C@](C)(OC(C)=O)C4)C(C)C1=O—
3692(4)megY—
92(1)
CC(C(C(C)C(O)C(C)(O)C(CC)O1)=O)CC(C)(OC2C[C@@H](N(C)C)[C@H](O)[C@@H](C)O2)C(O[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)C(C)C(O[C@@H]4O[C@@H](C)[C@H](OC(CC)=O)[C@](C)(OC(C)=O)C4)C(C)C1=O—
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