NPdia

BGC0000091PKS

Marineosin A;Marineosin B

Producing organism: Streptomyces sp. CNQ-617
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Unknown)
Total steps: 10
DOI: 10.1021/ja411544w
MIBiG entry: View on MIBiG ↗

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C₂₅H₃₅N₃O₂409.27 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Adenylation (A)

Acyl carrier (ACP)

Thioesterase (TE)

CoA-ligase (CAL)

Aminotransferase I/II

NAD-binding

10 steps · 9 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`91-1`	Start	—		`O=C(CC(O)C)O`	—
2	`91-2`	marP, marR, marQ, marJ	—	91-1 from: 91-1	`O=C(CCCCCCCCCC(O)C)O`	—
3	`91-3`	Start	—	Glycine	`NCC(O)=O`	—
4	`91-4`	marL	—	91-2;91-3 from: 91-2, 91-3	`O=C1CNC(CCCCCCCCCC(O)C)=C1`	—
5	`91-5`	Start	—	MBC subunit	`COC1=CC(C2=CC=CN2)=NC1C([H])=O`	—
6	`91-6`	?	—	91-4;91-5 from: 91-4, 91-5	`CC(O)CCCCCCCCCC1=CC=C(/C=C2C(OC)=CC(C3=CC=CN3)=N\2)C1`	—
7(1)	`91-7`	marG	—	91-6 from: 91-6	`C[C@H](O[C@@]12N=C(C3=CC=CN3)C=C1OC)C[C@]4([H])CCCCCCCC5=CC=C([C@]42[H])N5`	—
7(2)	`91-8`	marG	—	91-6 from: 91-6	`C[C@H](O[C@]12N=C(C3=CC=CN3)C=C1OC)C[C@]4([H])CCCCCCCC5=CC=C([C@]42[H])N5`	—
8(1)	`91(1)`	marA	—	91-7 from: 91-7	`C[C@H](O[C@@]12N=C(C3=CC=CN3)C[C@H]1OC)C[C@]4([H])CCCCCCCC5=CC=C([C@]42[H])N5`	—
8(2)	`91(2)`	marA	—	91-8 from: 91-8	`C[C@H](O[C@]12N=C(C3=CC=CN3)C[C@@H]1OC)C[C@]4([H])CCCCCCCC5=CC=C([C@]42[H])N5`	—

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