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BGC0000090PKS

Macbecin;Macbecin II

Producing organism
Actinosynnema pretiosum subsp. pretiosum
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Actinosynnema
Biosynthetic class
PKS (Unknown)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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C30H42N2O8558.29 Da

Gene Cluster Map23 genes · 100,588 bp

20 kb100.6 kb visible · 100,588 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
FkFkbH-like
MTMethyltransferase
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1Load
mbcAI
+AHBA
Step 2M1
mbcAI
+Methylmalonyl-CoA
Step 3M2
mbcAI
+Methoxymalonyl-ACP
Step 4M3
mbcAI
+Methylmalonyl-CoA
Step 5M4
mbcAII
+Methylmalonyl-CoA
Step 6M5
mbcAII
+Methylmalonyl-CoA
Step 7M6
mbcAIII
+Malonyl-CoA
Step 8M7
mbcAIII
+Methylmalonyl-CoA
Step 9
?
Step 10
?
Step 11
?
+90(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
190-1mbcAILoading
AHBA
NC1=CC(C(O)=O)=CC(O)=C1—
290-2mbcAIM1
90-1;Methylmalonyl-CoA
from: 90-1
NC1=CC(C[C@@H](C)C(O)=O)=CC(O)=C1—
390-3mbcAIM2
90-2;Methoxymalonyl-ACP
from: 90-2
NC1=CC(C[C@@H](C)CC(OC)C(O)=O)=CC(O)=C1—
490-4mbcAIM3
90-3;Methylmalonyl-CoA
from: 90-3
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)C(O)=O)=CC(O)=C1—
590-5mbcAIIM4
90-4;Methylmalonyl-CoA
from: 90-4
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/C(O)=O)=CC(O)=C1—
690-6mbcAIIM5
90-5;Methylmalonyl-CoA
from: 90-5
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(C)C(O)=O)=CC(O)=C1—
790-7mbcAIIIM6
90-6;Malonyl-CoA
from: 90-6
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(C)CCC(O)=O)=CC(O)=C1—
890-8mbcAIIIM7
90-7;Methylmalonyl-CoA
from: 90-7
NC1=CC(C[C@@H](C)CC(OC)C(O)[C@@H](C)/C=C(C)/[C@H](O)C(C)CC/C=C(C(O)=O)\C)=CC(O)=C1—
990-9?—
90-8
from: 90-8
C[C@H]1/C=C\C=C(C)\C(NC2=CC(O)=CC(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@@H]1O)=C2)=O—
1090(1)?—
90-9
from: 90-9
OC1=C(C=C(O)C=C1NC(/C(C)=C/C=C\2)=O)[C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@H]2C—
1190(2)?—
90(1)
O=C(C(NC(/C(C)=C/C=C\1)=O)=C2)C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@H]1C)=C([H])C2=O—
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