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BGC0000087PKS

Lasalocid

Producing organism
Streptomyces lasalocidi
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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lasalocid
C34H53NaO8612.36 Da

Gene Cluster Map53 genes · 110,927 bp

20 kb110.9 kb visible · 110,927 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CycPolyketide cyclase

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
lasAI
+Malonyl-CoA
Step 2M1
lasAI
+Ethylmalonyl-CoA
Step 3M2
lasAI
+Malonyl-CoA
Step 4M3
lasAII
+Ethylmalonyl-CoA
Step 5M4
lasAII
+Methylmalonyl-CoA
Step 6M5
lasAII
+Ethylmalonyl-CoA
Step 7M6
lasAIII
+Methylmalonyl-CoA
Step 8M7
lasAIV
+Methylmalonyl-CoA
Step 9M8
lasAV
+Malonyl-CoA
Step 10M9
lasAV
+Malonyl-CoA
Inactive: KR
Step 11M10
lasAVI
+Methylmalonyl-CoA
Step 12M11
lasAVII
+Malonyl-CoA
Step 13TE
lasAVII
Step 14
lasC
Step 15
lasB
Step 16
lasB
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
187-1lasAILoading
Malonyl-CoA
O=C(O)C—
287-2lasAIM1
87-1;Ethylmalonyl-CoA
from: 87-1
C/C=C(CC)/C(O)=O—
387-3lasAIM2
87-2;Malonyl-CoA
from: 87-2
C/C=C(CC)/CCC(O)=O—
487-4lasAIIM3
87-3;Ethylmalonyl-CoA
from: 87-3
C/C=C(CC)/CC/C=C(CC)/C(O)=O—
587-5lasAIIM4
87-4;Methylmalonyl-CoA
from: 87-4
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)C(O)=O—
687-6lasAIIM5
87-5;Ethylmalonyl-CoA
from: 87-5
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C(O)=O—
787-7lasAIIIM6
87-6;Methylmalonyl-CoA
from: 87-6
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C([C@@H](C)C(O)=O)=O—
887-8lasAIVM7
87-7;Methylmalonyl-CoA
from: 87-7
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)C(O)=O)=O—
987-9lasAVM8
87-8;Malonyl-CoA
from: 87-8
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)CCC(O)=O)=O—
1087-10lasAVM9
87-9;Malonyl-CoA
from: 87-9
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)CCC(CC(O)=O)=O)=O{'Inactive': ['KR']}
1187-11lasAVIM10
87-10;Methylmalonyl-CoA
from: 87-10
O=C(CC[C@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C/C(CC)=C/CC/C(CC)=C/C)C)O)CC)=O)C)O)C)C/C=C(C(O)=O)/C—
1287-12lasAVIIM11
87-11;Malonyl-CoA
from: 87-11
O=C(CC[C@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C/C(CC)=C/CC/C(CC)=C/C)C)O)CC)=O)C)O)C)C/C=C(C(CC(O)=O)=O)/C—
1387-13lasAVIITE
87-12
from: 87-12
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C/C(CC)=C/CC/C(CC)=C/C)C)O)CC)=O)C)O)CCC1=C(C(O)=O)C(O)=C(C)C=C1—
1487-14lasC—
87-13
from: 87-13
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C[C@@](CC)(O1)[C@H]1CC[C@@](CC)(O2)[C@H]2C)C)O)CC)=O)C)O)CCC3=C(C(O)=O)C(O)=C(C)C=C3—
1587-15lasB—
87-14
from: 87-14
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@@H]1[C@H](C[C@]([C@H](O)CC[C@]2(CC)[C@H](O2)C)(CC)O1)C)CC)=O)C)O)CCC3=C(C(O)=O)C(O)=C(C)C=C3—
1687lasB—
87-15
from: 87-15
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@@H]1[C@H](C[C@]([C@H](O2)CC[C@@](CC)(O)[C@@H]2C)(CC)O1)C)CC)=O)C)O)CCC3=C(C(O)=O)C(O)=C(C)C=C3—
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