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BGC0000086PKS

Lasalocid

Producing organism
Streptomyces lasalocidi
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
—
Loading…
lasalocid
C34H53NaO8612.36 Da

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
lsd11
+Malonyl-CoA
Step 2M1
lsd11
+Ethylmalonyl-CoA
Step 3M2
lsd11
+Malonyl-CoA
Step 4M3
lsd12
+Ethylmalonyl-CoA
Step 5M4
lsd12
+Methylmalonyl-CoA
Step 6M5
lsd12
+Ethylmalonyl-CoA
Step 7M6
lsd13
+Methylmalonyl-CoA
Step 8M7
lsd14
+Methylmalonyl-CoA
Step 9M8
lsd15
+Malonyl-CoA
Step 10M9
lsd15
+Malonyl-CoA
Inactive: KR
Step 11M10
lsd16
+Methylmalonyl-CoA
Step 12M11
lsd17
+Malonyl-CoA
Step 13TE
lsd17
Step 14
lsd18
Step 15
lsd19
Step 16
lsd19
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
186-1lsd11Loading
Malonyl-CoA
O=C(O)C—
286-2lsd11M1
86-1;Ethylmalonyl-CoA
from: 86-1
C/C=C(CC)/C(O)=O—
386-3lsd11M2
86-2;Malonyl-CoA
from: 86-2
C/C=C(CC)/CCC(O)=O—
486-4lsd12M3
86-3;Ethylmalonyl-CoA
from: 86-3
C/C=C(CC)/CC/C=C(CC)/C(O)=O—
586-5lsd12M4
86-4;Methylmalonyl-CoA
from: 86-4
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)C(O)=O—
686-6lsd12M5
86-5;Ethylmalonyl-CoA
from: 86-5
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C(O)=O—
786-7lsd13M6
86-6;Methylmalonyl-CoA
from: 86-6
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C([C@@H](C)C(O)=O)=O—
886-8lsd14M7
86-7;Methylmalonyl-CoA
from: 86-7
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)C(O)=O)=O—
986-9lsd15M8
86-8;Malonyl-CoA
from: 86-8
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)CCC(O)=O)=O—
1086-10lsd15M9
86-9;Malonyl-CoA
from: 86-9
C/C=C(CC)/CC/C=C(CC)/C[C@H](C)[C@H](O)[C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)CCC(CC(O)=O)=O)=O{'Inactive': ['KR']}
1186-11lsd16M10
86-10;Methylmalonyl-CoA
from: 86-10
O=C(CC[C@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C/C(CC)=C/CC/C(CC)=C/C)C)O)CC)=O)C)O)C)C/C=C(C(O)=O)/C—
1286-12lsd17M11
86-11;Malonyl-CoA
from: 86-11
O=C(CC[C@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C/C(CC)=C/CC/C(CC)=C/C)C)O)CC)=O)C)O)C)C/C=C(C(CC(O)=O)=O)/C—
1386-13lsd17TE
86-12
from: 86-12
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C/C(CC)=C/CC/C(CC)=C/C)C)O)CC)=O)C)O)CCC1=C(C(O)=O)C(O)=C(C)C=C1—
1486-14lsd18—
86-13
from: 86-13
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@H]([C@H](C[C@@](CC)(O1)[C@H]1CC[C@@](CC)(O2)[C@H]2C)C)O)CC)=O)C)O)CCC3=C(C(O)=O)C(O)=C(C)C=C3—
1586-15lsd19—
86-14
from: 86-14
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@@H]1[C@H](C[C@]([C@H](O)CC[C@]2(CC)[C@H](O2)C)(CC)O1)C)CC)=O)C)O)CCC3=C(C(O)=O)C(O)=C(C)C=C3—
1686lsd19—
86-15
from: 86-15
C[C@@H]([C@@H]([C@@H](C([C@@H]([C@@H]1[C@H](C[C@]([C@H](O2)CC[C@@](CC)(O)[C@@H]2C)(CC)O1)C)CC)=O)C)O)CCC3=C(C(O)=O)C(O)=C(C)C=C3—
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