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BGC0000085PKS

Lankamycin

Producing organism
Streptomyces rochei
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces rochei group
Biosynthetic class
PKS (Unknown)
Total steps
17
DOI
MIBiG entry
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lankamycin
C42H72O16832.48 Da

Gene Cluster Map30 genes · 68,094 bp

KSKSKSKSKSKS10 kb68.1 kb visible · 68,094 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
MTMethyltransferase
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1
Start
+L-isoleucine
Step 13
Start
+NDP-L-arcanose
Step 16
Start
+NDP-D-chalcose
Step 2
?
Step 3
?
Step 4Load
lkmAI
Step 5M1
lkmAI
+Methylmalonyl-CoA
Step 6M2
lkmAI
+Methylmalonyl-CoA
Step 7M3
lkmAII
+Methylmalonyl-CoA
Inactive: KR
Step 8M4
lkmAII
+Methylmalonyl-CoA
Step 9M5
lkmAIII
+Methylmalonyl-CoA
Step 10M6
lkmAIII
+Methylmalonyl-CoA
Step 11TE
lkmAIII
Step 12
lkmK
Step 14
lkmL
Step 15
lkmF
Step 17
lkmI, lkmJ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
185-1Start—
L-isoleucine
C[C@H]([C@H](N)C(O)=O)CC—
285-2?—
85-1
from: 85-1
C[C@H](C(C(O)=O)=O)CC—
385-3?—
85-2
from: 85-2
C[C@H](C([R])=O)CC—
485-4lkmAILoading
85-3
from: 85-3
C[C@H](C(O)=O)CC—
585-5lkmAIM1
85-4;Methylmalonyl-CoA
from: 85-4
C[C@H]([C@@H](O)[C@H](C)C(O)=O)CC—
685-6lkmAIM2
85-5;Methylmalonyl-CoA
from: 85-5
C[C@H]([C@@H](O)[C@H](C)[C@H](O)[C@@H](C)C(O)=O)CC—
785-7lkmAIIM3
85-6;Methylmalonyl-CoA
from: 85-6
C[C@H]([C@@H](O)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C(O)=O)=O)CC{'Inactive': ['KR']}
885-8lkmAIIM4
85-7;Methylmalonyl-CoA
from: 85-7
C[C@H]([C@@H](O)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@H](C)C(O)=O)=O)CC—
985-9lkmAIIIM5
85-8;Methylmalonyl-CoA
from: 85-8
C[C@H]([C@@H](O)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)C(O)=O)=O)CC—
1085-10lkmAIIIM6
85-9;Methylmalonyl-CoA
from: 85-9
C[C@H]([C@@H](O)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@@H](C)C(O)=O)=O)CC—
1185-11lkmAIIITE
85-10
from: 85-10
C[C@@H]1[C@@H](O)[C@@H](C)C[C@@H](C)C([C@H](C)[C@@H](O)[C@@H](C)[C@@H](C(C)CC)OC([C@H](C)[C@H]1O)=O)=O—
1285-12lkmK—
85-11
from: 85-11
C[C@@H]1[C@@H](O)[C@@H](C)C[C@@H](C)C([C@H](C)[C@@H](O)[C@@H](C)[C@@H](C(C)[C@@H](O)C)OC([C@H](C)[C@H]1O)=O)=O—
1385-13Start—
NDP-L-arcanose
O[C@@H]1O[C@@H](C)[C@@H]([R])[C@@](OC)(C)C1—
1485-14lkmL—
85-12;85-13
from: 85-12, 85-13
C[C@@H]1O[C@@H](O[C@@H]2[C@@H](C)C(O[C@H](C(C)[C@@H](O)C)[C@H](C)[C@H](O)[C@@H](C)C([C@H](C)C[C@H](C)[C@H](O)[C@H]2C)=O)=O)C[C@](OC)(C)[C@@H]1O—
1585-15lkmF—
85-14
from: 85-14
C[C@@H]1O[C@@H](O[C@@H]2[C@@H](C)C(O[C@H](C(C)[C@@H](O)C)[C@H](C)[C@H](O)[C@@H](C)C([C@@](C)(O)C[C@H](C)[C@H](O)[C@H]2C)=O)=O)C[C@](OC)(C)[C@@H]1O—
1685-16Start—
NDP-D-chalcose
[R]C1[C@H](O)[C@@H](OC)C[C@@H](C)O1—
1785lkmI, lkmJ?—
85-15;85-16
from: 85-15, 85-16
C[C@@H]1[C@@H](OC2[C@H](O)[C@@H](OC)C[C@@H](C)O2)[C@@H](C)C[C@](C)(O)C([C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C(C)[C@@H](O)C)OC([C@H](C)[C@H]1O[C@@H]3O[C@@H](C)[C@@H](OC(C)=O)[C@@](OC)(C)C3)=O)=O—
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