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BGC0000083PKS

Lactimidomycin;8,9-dihydrolactimidomycin;8-hydroxy-8,9-dihydrolactidomycin;17-hydroxy-8-desmethoxy-isomigrastatin

Producing organism
Streptomyces amphibiosporus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
Loading…
C26H35NO6457.25 Da

Gene Cluster Map9 genes · 50,543 bp

ATKSKSKSKSKSKSKSKSKSKSDH2TEAT10 kb50.5 kb visible · 50,543 bp total
Biosynthetic (core)
Biosynthetic (additional)
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TdTrans-AT docking
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
MTMethyltransferase
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

16 steps · 14 edges
Step 1Load
ACY01398.1
Trans-AT
Step 16
ACY01404.1
+83(2)/83(3)
Step 2
ACY01399.1
Step 3M2
ACY01400.1
Trans-AT
Step 4M3
ACY01400.1
Trans-AT
Step 5M4
ACY01400.1;ACY01401.1
Trans-AT
Step 6M5
ACY01401.1
Trans-AT
Step 7M6
ACY01401.1
Trans-AT
Step 8M7
ACY01401.1
Trans-AT
Step 9M8;9
ACY01401.1
Trans-AT
Step 10M9
ACY01401.1
Trans-AT
Step 11M10
ACY01401.1;ACY01402.1
Trans-AT
Step 12M11
ACY01402.1
Trans-AT
Step 13TE
ACY01402.1
Step 14
ACY01404.1
+83(1)
Step 15
ACY01404.1
+83(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
183-1ACY01398.1Loading
O=C(O)CC(O)=O{'transAT': ['ACY01397.1', '…
283-2ACY01399.1—
83-1
from: 83-1
O=C(O)CC(N)=O—
383-3ACY01400.1M2
83-2
from: 83-2
NC(C/C=C/C(O)=O)=O{'transAT': ['ACY01403.1', '…
483-4ACY01400.1M3
83-3
from: 83-3
O=C1NC(CC(CC(O)=O)C1)=O{'transAT': ['ACY01403.1', '…
583-5ACY01400.1;ACY01401.1M4
83-4
from: 83-4
O=C1NC(CC(CC(O)CC(O)=O)C1)=O{'transAT': ['ACY01403.1', '…
683-6ACY01401.1M5
83-5
from: 83-5
O=C1NC(CC(CC(O)CC(C(C(O)=O)C)=O)C1)=O{'Missing': ['MT'], 'transAT…
783-7ACY01401.1M6
83-6
from: 83-6
O=C1NC(CC(CC(O)CC(C(/C=C(C(O)=O)\C)C)=O)C1)=O{'transAT': ['ACY01403.1', '…
883-8ACY01401.1M7
83-7
from: 83-7
O=C1NC(CC(CC(O)CC(C(/C=C(C(O)C(C(O)=O)C)\C)C)=O)C1)=O{'transAT': ['ACY01403.1', '…
983-9ACY01401.1M8;9
83-8
from: 83-8
O=C1NC(CC(CC(O)CC(C(/C=C(C(O)C(CCC(O)=O)C)\C)C)=O)C1)=O{'Missing': ['KR', 'DH', 'ER…
1083-10ACY01401.1M9
83-9
from: 83-9
O=C1NC(CC(CC(O)CC(C(/C=C(C(O)C(CC/C=C/C(O)=O)C)\C)C)=O)C1)=O{'transAT': ['ACY01403.1', '…
1183-11ACY01401.1;ACY01402.1M10
83-10
from: 83-10
O=C1NC(CC(CC(O)CC(C(/C=C(C(O)C(CC/C=C/CCC(O)=O)C)\C)C)=O)C1)=O{'Missing': ['KR', 'ER'], 't…
1283-12ACY01402.1M11
83-11
from: 83-11
O=C1NC(CC(CC(O)CC(C(C)/C=C(C)/C(O)C(C)CC/C=C/CC/C=C/C(O)=O)=O)C1)=O{'transAT': ['ACY01403.1', '…
1383(1)ACY01402.1TE
83-12
from: 83-12
C[C@H]([C@H](/C(C)=C/[C@H](C)C(C[C@H](O)CC(CC1=O)CC(N1)=O)=O)O2)CC/C=C/CC/C=C/C2=O—
1483(2)ACY01404.1—
83(1)
C[C@H]([C@H](/C(C)=C/[C@H](C)C(C[C@H](O)CC(CC1=O)CC(N1)=O)=O)O2)/C=C\C=C\CC/C=C/C2=O—
1583(3)ACY01404.1—
83(1)
C[C@H]([C@H](/C(C)=C/[C@H](C)C(C[C@H](O)CC(CC1=O)CC(N1)=O)=O)O2)C[C@H](O)/C=C/CC/C=C/C2=O—
1683(4)ACY01404.1—
83(2)/83(3)
C[C@H]([C@H](/C(C)=C/[C@H](C)C(C[C@H](O)CC(CC1=O)CC(N1)=O)=O)O2)[C@H](O)C/C=C/CC/C=C/C2=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture