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BGC0000082PKS

Kijanimicin

Producing organism
Actinomadura kijaniata
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Thermomonosporaceae›Actinomadura
Biosynthetic class
PKS (Unknown)
Total steps
32
DOI
MIBiG entry
View on MIBiG ↗
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kijanimicin
C67H100N2O241316.67 Da

Gene Cluster Map43 genes · 107,627 bp

20 kb107.6 kb visible · 107,627 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
MTMethyltransferase
AmTAminotransferase V
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

32 steps · 32 edges
Step 1Load
KijS1
+Malonyl-CoA
Step 13
Start
Step 19
Start
Step 2M1
KijS1
+Methylmalonyl-CoA
Step 14
KijC;KijD
Step 20
KijD5
Step 3M2
KijS1
+Malonyl-CoA
Step 15
KijE
Step 21
KijD4
Step 4M3
KijS1
+Methylmalonyl-CoA
Step 22
KijB1
Step 5M4
KijS2
+Malonyl-CoA
Inactive: DH
Step 23
KijD10
Step 26
KijD2
Step 6M5
KijS2
+Methylmalonyl-CoA
Step 24
KijD11
Step 27
KijD1
Step 7M6
KijS2
+Malonyl-CoA
Step 25
KijC2
Step 28
KijD3
Step 8M7
KijS2
+Malonyl-CoA
Step 29
KijD7
Step 9M8
KijS3
+Methylmalonyl-CoA
Inactive: DH
Step 30
KijD8
Step 10M9
KijS4
+Methylmalonyl-CoA
Step 31
KijB3
Step 11M10
KijS4
+Methylmalonyl-CoA
Step 12M11
KijS5
+Malonyl-CoA
Inactive: KR
Step 16
KijB
Step 32
(KijA4, KijC1, KijC3, K…
Step 17
KijE
Step 18
KijA
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions32 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
182-1KijS1Loading
Malonyl-CoA
O=C(C)O—
282-2KijS1M1
82-1;Methylmalonyl-CoA
from: 82-1
C/C=C(C)/C(O)=O—
382-3KijS1M2
82-2;Malonyl-CoA
from: 82-2
C/C=C(C)/C=C/C(O)=O—
482-4KijS1M3
82-3;Methylmalonyl-CoA
from: 82-3
C/C=C(C)/C=C/C=C(C)/C(O)=O—
582-5KijS2M4
82-4;Malonyl-CoA
from: 82-4
C/C=C(C)/C=C/C=C(C)/[C@@H](O)CC(O)=O{'Inactive': ['DH']}
682-6KijS2M5
82-5;Methylmalonyl-CoA
from: 82-5
C/C=C(C)/C=C/C=C(C)/[C@@H](O)C/C=C(C)/C(O)=O—
782-7KijS2M6
82-6;Malonyl-CoA
from: 82-6
C/C=C(C)/C=C/C=C(C)/[C@@H](O)C/C=C(C)/C=C/C(O)=O—
882-8KijS2M7
82-7;Malonyl-CoA
from: 82-7
C/C=C(C)/C=C/C=C(C)/[C@@H](O)C/C=C(C)/C=C/C=C/C(O)=O—
982-9KijS3M8
82-8;Methylmalonyl-CoA
from: 82-8
C/C=C(C)/C=C/C=C(C)/[C@@H](O)C/C=C(C)/C=C/C=C/[C@@H](O)[C@@H](C)C(O)=O{'Inactive': ['DH']}
1082-10KijS4M9
82-9;Methylmalonyl-CoA
from: 82-9
C/C=C(C)/C=C/C=C(C)/[C@@H](O)C/C=C(C)/C=C/C=C/[C@@H](O)[C@H](C[C@H](C)C(O)=O)C—
1182-11KijS4M10
82-10;Methylmalonyl-CoA
from: 82-10
O=C(O)C([C@@](/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C)([H])C=C1)(C)[C@@]2([H])[C@@]1([H])[C@@H](O)[C@@H](C)C[C@@H]2C—
1282-12KijS5M11
82-11;Malonyl-CoA
from: 82-11
O=C(CC(O)=O)C([C@@](/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C)([H])C=C1)(C)[C@@]2([H])[C@@]1([H])[C@@H](O)[C@@H](C)C[C@@H]2C{'Inactive': ['KR']}
1382-13Start—
O[C@@H](C(OP(O)(O)=O)=O)COP(O)(O)=O—
1482-14KijC;KijD—
82-13
from: 82-13
O[C@H](CO)C(O)=O—
1582-15KijE—
82-14
from: 82-14
O[C@H](CO)C([R])=O—
1682-16KijB—
82-12;82-15
from: 82-12, 82-15
O=C(/C(C(O)=O)=C(O)/[C@@H](O)CO)[C@@]([C@@](/C(C)=C/C[C@H](O)/C(C)=C\C=C\C(C)=C\C)([H])C=C1)(C)[C@@]2([H])[C@@]1([H])[C@@H](O)[C@@H](C)C[C@@H]2C—
1782-17KijE—
82-16
from: 82-16
O=C(C(C(O1)=O)=C(O)C1CO)[C@@]([C@@](/C(C)=C/C[C@H](O)/C(C)=C\C=C\C(C)=C\C)([H])C=C2)(C)[C@@]3([H])[C@@]2([H])[C@@H](O)[C@@H](C)C[C@@H]3C—
1882-18KijA—
82-17
from: 82-17
O=C1[C@@]([C@@](/C(C)=C/C[C@H](O)/C(C)=C\[C@@](C=C([C@@H](C2)C)CO)([H])[C@@]32C(O)=C1C(O3)=O)([H])C=C4)(C)[C@@]5([H])[C@@]4([H])[C@@H](O)[C@@H](C)C[C@@H]5C—
1982-19Start—
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O—
2082-20KijD5—
82-19
from: 82-19
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O—
2182-21KijD4—
82-20
from: 82-20
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1=O—
2282-22KijB1—
82-21
from: 82-21
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
2382-23KijD10—
82-22
from: 82-22
C[C@H]1O[C@H]([R])C[C@@H](O)C1=O—
2482-24KijD11—
82-23
from: 82-23
O=C1[C@H](C)O[C@H]([R])C[C@H]1O—
2582-25KijC2—
82-24
from: 82-24
C[C@H]1[C@H](O)[C@H](O)C[C@@H]([R])O1—
2682-26KijD2—
82-22
from: 82-22
C[C@H]1O[C@H]([R])C[C@@H](N)C1=O—
2782-27KijD1—
82-26
from: 82-26
C[C@H]1O[C@H]([R])C[C@](C)(N)C1=O—
2882-28KijD3—
82-27
from: 82-27
C[C@H]1O[C@H]([R])C[C@](C)([N+]([O-])=O)C1=O—
2982-29KijD7—
82-28
from: 82-28
C[C@H]1O[C@H]([R])C[C@](C)([N+]([O-])=O)[C@H]1N—
3082-30KijD8—
82-29
from: 82-29
C[C@H]1O[C@H]([R])C[C@](C)([N+]([O-])=O)[C@H]1NC—
3182-31KijB3—
82-30
from: 82-30
C[C@H]1O[C@H]([R])C[C@](C)([N+]([O-])=O)[C@H]1NC(O)=O—
3282(KijA4, KijC1, KijC3, KijC4), (KijD9, KijA1)—
82-12;82-24;82-24;82-24;82-24;82-31
from: 82-12, 82-24, 82-24, 82-24, 82-24, 82-31
O=C1[C@@]([C@@](/C(C)=C/C[C@H](O[C@H]2C[C@](C)([N+]([O-])=O)[C@@H](NC(OC)=O)[C@@H](C)O2)/C(C)=C\[C@@](C=C([C@@H](C3)C)CO)([H])[C@@]43C(O)=C1C(O4)=O)([H])C=C5)(C)[C@@]6([H])[C@@]5([H])[C@@H](O[C@H]7C[C@@H](O[C@H]8C[C@@H](O[C@H]9C[C@@H](O)[C@@H](O)[C@H](C)O9)[C@@H](O[C@@H]%10C[C@@H](O)[C@@H](O)[C@H](C)O%10)[C@H](C)O8)[C@@H](O)[C@H](C)O7)[C@@H](C)C[C@@H]6C—
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