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BGC0000081Hybrid

Kedarcidin

Producing organism
Streptoalloteichus sp. ATCC 53650
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Streptoalloteichus
Biosynthetic class
NRPS (Type I);PKS (Iterative type I)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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kedarcidin
C53H60ClN3O161029.37 Da

Gene Cluster Map115 genes · 135,420 bp

20 kb135.4 kb visible · 135,420 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
FkFkbH-like
DH2Dehydratase (DH2)
AmTAminotransferase I/II
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

18 steps · 15 edges
Step 1
Start
+D-Glucose-1-phosp…
Step 6
Start
+2-Aza-L-phenylala…
Step 11
Start
+3,6,8-Trihydroxy-…
Step 16
?
+Acetyl-CoA, Malonyl-CoA
Step 2
?
Step 7
AFV52156.1
Step 12
AFV52151.1
Step 17
AFV52152.1
Step 3
AFV52213.1, AFV52155.1,…
Step 8
AFV52190.1
Step 13
AFV52157.1
Step 4
AFV52186.1, AFV52185.1
Step 5
AFV52158.1, AFV52159.1,…
Step 9
AFV52191.1;AFV52209.1
Step 14
AFV52163.1
Step 10
AFV52210.1, AFV52147.1
Step 15
AFV52187.1
Step 18
AFV52161.1, AFV52165.1,…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
181-1Start—
D-Glucose-1-phosphate
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
281-2?—
81-1
from: 81-1
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1C)C1=O—
381-3AFV52213.1, AFV52155.1, AFV52211.1—
81-2
from: 81-2
[R][C@@H]1C[C@H](O)C([C@H](C)O1)=O—
481-4AFV52186.1, AFV52185.1—
81-3
from: 81-3
[R][C@@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1—
581-5AFV52158.1, AFV52159.1, AFV52160.1—
81-3
from: 81-3
C[C@@H]1O[C@H]([R])C[C@H](O)[C@@H]1N(C)C—
681-6Start—
2-Aza-L-phenylalanine
[R]C([C@](N)([H])CC1=NC=CC=C1)=O—
781-7AFV52156.1—
81-6
from: 81-6
[O-]C([C@]([NH3+])([H])CC1=NC=C(O)C=C1)=O—
881-8AFV52190.1—
81-7
from: 81-7
[O-]C(C[C@]([NH3+])([H])C1=NC=C(O)C=C1)=O—
981-9AFV52191.1;AFV52209.1—
81-8
from: 81-8
OC(C[C@](N)([H])C1=NC=C(O)C=C1)=O—
1081-10AFV52210.1, AFV52147.1—
81-9
from: 81-9
OC(C[C@](N)([H])C1=NC(Cl)=C(O)C=C1)=O—
1181-11Start—
3,6,8-Trihydroxy-2-naphthoic acid
OC1=C(C=C(C(O)=O)C(O)=C2)C2=CC(O)=C1—
1281-12AFV52151.1—
81-11
from: 81-11
OC1=C(C=C(C(O)=O)C(O)=C2)C2=CC(O)=C1O—
1381-13AFV52157.1—
81-12
from: 81-12
OC1=CC2=CC(OC)=C(OC)C(OC)=C2C=C1C(O)=O—
1481-14AFV52163.1—
81-13
from: 81-13
[R]C1=C(OC)C(OC)=C(C=C(C(O)=O)C(O)=C2)C2=C1—
1581-15AFV52187.1—
81-14
from: 81-14
[R]C1=C(C(OC)=C2C=C(C(O)=CC2=C1)C([R*])=O)OC—
1681-16?—
Acetyl-CoA;Malonyl-CoA
O[C@@H]1[C@@]23C(C#C/C([C@H]4CO4)=C\C#C[C@@H]2O3)=C[C@H]1O—
1781-17AFV52152.1—
81-16
from: 81-16
O[C@H](CO)/C1=C/C#C[C@H]2[C@@]3(O2)[C@@H](O)[C@H](O)C=C3C#C1—
1881AFV52161.1, AFV52165.1, AFV52192.1—
81-4;81-5;81-10-81-15
from: 81-4, 81-5, 81-10-81-15
C[C@]1(O)[C@@H](O)[C@H](C)O[C@@H](O[C@@H]2[C@@]34C(C#C/C([C@@H]5O[C@@H]6O[C@@H](C)[C@@H](N(C)C)[C@@H](O)C6)=C\C#C[C@@H]3O4)=C[C@@H]2OC7=C(Cl)N=C([C@H](NC(C(C(O)=CC8=C9)=CC8=C(OC)C(OC)=C9[R])=O)CC(OC5)=O)C=C7)C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture