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BGC0000079PKS

X-14547

Producing organism
Streptomyces antibioticus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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X-14547
C31H43NO4493.32 Da

Gene Cluster Map23 genes · 79,604 bp

AKSKSKSKSKSKSKSKSKSKSKS20 kb79.6 kb visible · 79,604 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1
Start
+Proline
Step 2
idmJ
Step 3
idmI
Step 5M1
idmL
+Malonyl-CoA
Step 6M2
idmL
+Malonyl-CoA
Step 7M3
idmL
+Ethylmalonyl-CoA
Step 8M4
idmM
+Malonyl-CoA
Step 9M5
idmM
+Malonyl-CoA
Step 10M6
idmN
+Malonyl-CoA
Step 11M7
idmN
+Ethylmalonyl-CoA
Step 12M8
idmN
+Methylmalonyl-CoA
Step 13M9
idmO
+Malonyl-CoA
Step 14M10
idmP
+Methylmalonyl-CoA
Step 15M11
idmP
Step 16MTE?
idmP
Step 17
idmH
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
179-1Start—
Proline
[O-]C([C@H]1NCCC1)=O—
279-2idmJ—
79-1
from: 79-1
OC([C@H]1NCCC1)=O—
379-3idmI—
79-2
from: 79-2
OC(C1=CC=CN1)=O—
579-4idmLM1
79-3;Malonyl-CoA
from: 79-3
O=C(CC(O)=O)C1=CC=CN1—
679-5idmLM2
79-4;Malonyl-CoA
from: 79-4
O=C(C[C@H](O)CC(O)=O)C1=CC=CN1—
779-6idmLM3
79-5;Ethylmalonyl-CoA
from: 79-5
O=C(C[C@H](O)CC[C@H](CC)C(O)=O)C1=CC=CN1—
879-7idmMM4
79-6;Malonyl-CoA
from: 79-6
O=C(C[C@H](O)CC[C@H](CC)/C=C/C(O)=O)C1=CC=CN1—
979-8idmMM5
79-7;Malonyl-CoA
from: 79-7
O=C(C[C@H](O)CC[C@H](CC)/C=C/C=C/C(O)=O)C1=CC=CN1—
1079-9idmNM6
79-8;Malonyl-CoA
from: 79-8
O=C(C[C@H](O)CC[C@H](CC)/C=C/C=C/C=C/C(O)=O)C1=CC=CN1—
1179-10idmNM7
79-9;Ethylmalonyl-CoA
from: 79-9
O=C(C[C@H](O)CC[C@H](CC)/C=C/C=C/C=C/C=C(CC)/C(O)=O)C1=CC=CN1—
1279-11idmNM8
79-10;Methylmalonyl-CoA
from: 79-10
O=C(C[C@H](O)CC[C@H](CC)/C=C/C=C/C=C/C=C(CC)/[C@H](O)[C@@H](C)C(O)=O)C1=CC=CN1—
1379-12idmOM9
79-11;Malonyl-CoA
from: 79-11
O=C(C[C@H](O)CC[C@H](CC)/C=C/C=C/C=C/C=C(CC)/[C@H](O)[C@@H](C)CCC(O)=O)C1=CC=CN1—
1479-13idmPM10
79-12;Methylmalonyl-CoA
from: 79-12
O=C(C[C@H](O)CC[C@H](CC)/C=C/C=C/C=C/C=C(CC)/[C@H](O)[C@@H](C)CC[C@H](O)[C@@H](C)C(O)=O)C1=CC=CN1—
1579-14idmPM11
79-13
from: 79-13
O[C@@H](/C(CC)=C/C=C/C=C/C=C/[C@@H](CC)CC/C=C/C(C1=CC=CN1)=O)[C@@H](C)CC/C=C(C)/C(O)=O—
1679-15idmPMTE?
79-14
from: 79-14
O=C(O)[C@@H]([C@H]1CC[C@H](C)[C@H](/C(CC)=C/C=C/C=C/C=C/[C@@H](CC)CC/C=C/C(C2=CC=CN2)=O)O1)C—
1779idmH—
79-15
from: 79-15
O=C(O)[C@@H]([C@H]1CC[C@H](C)[C@H](/C(CC)=C/C=C/C=C/C=C/[C@@H](CC)CC/C=C/C(C2=CC=CN2)=O)O1)C—
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