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BGC0000078PKS

Incednine

Producing organism
Streptomyces sp. ML694-90F3
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
38
DOI
MIBiG entry
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incednine
C42H63N3O8737.46 Da

Gene Cluster Map75 genes · 137,957 bp

20 kb138.0 kb visible · 137,957 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
AmTAminotransferase I/II
AmTAminotransferase III
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

38 steps · 37 edges
Step 1
Start
+Glutamic acid
Step 7
Start
Step 12
Start
Step 17
Start
Step 2
idnL4
Step 8
idnM4;idnM2
Step 13
idnS2
Step 18
idnS7
Step 3
idnL3
Step 9
idnM1
Step 14
idnS3
Step 19
idnS6
Step 4
idnL1;idnL6
Step 10
idnM3
Step 15
idnS1
Step 20
idnS10
Step 5
idnL7
Step 11
idnM5
Step 16
idnS5
Step 21
idnS11
Step 6
idnL2;idnP1
Step 22
idnS12
Step 23
idnS13
Step 25Load
idnP1
Step 24
idnS8
Step 26M1
idnP1
+Methylmalonyl-CoA
Step 27M2
idnP1
+Malonyl-CoA
Step 28M3
idnP2
+Methylmalonyl-CoA
Step 29M4
idnP2
+Malonyl-CoA
Step 30M5
idnP2
+Malonyl-CoA
Step 31M6
idnP4
+Methylmalonyl-CoA
Step 32M7
idnP3
+Malonyl-CoA
Step 33M8
idnP3
+Malonyl-CoA
Step 34M9
idnP5
+Methylmalonyl-CoA
Step 35M10
idnP5
Step 36TE
idnP5
Step 37
idnO1
Step 38
idnS4, idnS14, idnO2
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions38 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
178-1Start—
Glutamic acid
O=C(CC[C@@H](C(O)=O)N)O—
278-2idnL4—
78-1
from: 78-1
O=C(CC(N)CC(O)=O)O—
378-3idnL3—
78-2
from: 78-2
O=C(C[C@@H](N)C)O—
478-4idnL1;idnL6—
78-3
from: 78-3
OC(C[C@@H](N)C)=O—
578-5idnL7—
78-4
from: 78-4
OC(C[C@@H](NC([R])=O)C)=O—
678-6idnL2;idnP1—
78-5
from: 78-5
OC(C[C@@H](NC([R])=O)C)=O—
778-7Start—
OC(C[R])C([R])=O—
878-8idnM4;idnM2—
78-7
from: 78-7
OC(CO)C(O)=O—
978-9idnM1—
78-8
from: 78-8
OC(C([H])=O)C(O)=O—
1078-10idnM3—
78-9
from: 78-9
OC(C(O)=O)C(O)=O—
1178-11idnM5—
78-10
from: 78-10
O=C(O)C(C(O)=O)OC—
1278-12Start—
OC[C@H]1O[C@H]([R])[C@H](NC(C)=O)[C@@H](O)[C@@H]1O—
1378-13idnS2—
78-12
from: 78-12
OC([C@H]1O[C@H]([R])[C@H](NC(C)=O)[C@@H](O)[C@@H]1O)=O—
1478-14idnS3—
78-13
from: 78-13
O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@@H]([R])OC1—
1578-15idnS1—
78-14
from: 78-14
O[C@H]1[C@H](O)[C@@H](N)[C@@H]([R])OC1—
1678-16idnS5—
78-15
from: 78-15
O[C@H]1[C@H](O)[C@@H](NC)[C@@H]([R])OC1—
1778-17Start—
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O—
1878-18idnS7—
78-17
from: 78-17
OC[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)[C@@H]1O—
1978-19idnS6—
78-18
from: 78-18
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1=O—
2078-20idnS10—
78-19
from: 78-19
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
2178-21idnS11—
78-20
from: 78-20
C[C@H]1O[C@H]([R])C[C@@H](O)C1=O—
2278-22idnS12—
78-21
from: 78-21
C[C@H]1O[C@H]([R])CCC1=O—
2378-23idnS13—
78-22
from: 78-22
C[C@H]1O[C@H]([R])CC[C@@H]1N—
2478-24idnS8—
78-23
from: 78-23
C[C@H]1O[C@H]([R])CC[C@@H]1NC—
2578-25idnP1Loading
78-6
from: 78-6
O=C(O)C[C@@H](NC([R])=O)C—
2678-26idnP1M1
78-25;Methylmalonyl-CoA
from: 78-25
C[C@H](NC([R])=O)C/C=C(C(O)=O)\C—
2778-27idnP1M2
78-26;Malonyl-CoA
from: 78-26
C[C@H](NC([R])=O)C/C=C(/C=C/C(O)=O)C—
2878-28idnP2M3
78-27;Methylmalonyl-CoA
from: 78-27
C[C@H](NC([R])=O)C/C=C(/C=C/C=C(C(O)=O)\C)C—
2978-29idnP2M4
78-28;Malonyl-CoA
from: 78-28
C[C@H](NC([R])=O)C/C=C(/C=C/C=C(/C=C/C(O)=O)C)C—
3078-30idnP2M5
78-29;Malonyl-CoA
from: 78-29
C[C@H](NC([R])=O)C/C=C(/C=C/C=C(/C=C/C=C\C(O)=O)C)C—
3178-31idnP4M6
78-30;Methylmalonyl-CoA
from: 78-30
C[C@H](NC([R])=O)C/C=C(/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](C(O)=O)C)C)C—
3278-32idnP3M7
78-31;Malonyl-CoA
from: 78-31
C[C@H](NC([R])=O)C/C=C(/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](/C=C/C(O)=O)C)C)C—
3378-33idnP3M8
78-32;Malonyl-CoA
from: 78-32
C[C@H](NC([R])=O)C/C=C(/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](/C=C/C=C/C(O)=O)C)C)C—
3478-34idnP5M9
78-33;Methylmalonyl-CoA
from: 78-33
C[C@H](NC([R])=O)C/C=C(/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](/C=C/C=C/C=C(C(O)=O)\C)C)C)C—
3578-35idnP5M10
78-34;78-11
from: 78-34, 78-11
C[C@H](NC([R])=O)C/C=C(/C=C/C=C(/C=C/C=C\[C@H](O)[C@H](/C=C/C=C/C=C(/C=C(C(O)=O)\OC)C)C)C)C—
3678-36idnP5TE
78-35
from: 78-35
CC(/C=C/C=C\[C@H](O)[C@@H](C)/C=C/C=C/C=C(C)/C=C1\OC)=C\C=C\C(C)=C\C[C@H](C)NC1=O—
3778-37idnO1—
78-36
from: 78-36
CC(/C=C/C=C\[C@H](O)[C@](C)(O)/C=C/C=C/C=C(C)/C=C1\OC)=C\C=C\C(C)=C\C[C@H](C)NC1=O—
3878idnS4, idnS14, idnO2—
78-16;78-24;78-37
from: 78-16, 78-24, 78-37
CC(/C=C/C=C\[C@H](O[C@H]1[C@H](NC)[C@@H](O)[C@H](O[C@H]2CC[C@H](NC)[C@@H](C)O2)CO1)[C@](C)(O)/C=C/C=C/C=C(C)/C=C3\OC)=C\C=C\C(C)=C\C[C@H](C)NC3=O—
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